Browse our CYP3A4 Proteins (CYP3A4)

Full name:: Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Proteins (CYP3A4)

On www.antibodies-online.com are 9 Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) Proteins from 6 different suppliers available. Additionally we are shipping CYP3A4 Antibodies (163) and CYP3A4 Kits (35) and many more products for this protein. A total of 218 CYP3A4 products are currently listed.

Synonyms:: CP33, CP34, CYP3A, CYP3A3, CYP3A4, CYP3A12, CYP3A21, CYP3A80, CYPIIIA3, CYPIIIA4, CYPIIIA21, HLP, MGC108372, NF-25, P450C3, P450PCN1

list all proteins	Gene Name	GeneID	UniProt
	CYP3A4	1576	P08684
	CYP3A4
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CYP3A4 Proteins (CYP3A4) by Origin

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Relevant Pathways for CYP3A4 Proteins

Steroid Hormone Biosynthesis

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More Proteins for CYP3A4 Interaction Partners

Human Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) interaction partners

The metabolites are predominantly catalyzed by CYP3A4 (77% approximately 87%), with a moderate contribution from CYP3A5 (show CYP3A5 Proteins) (5% approximately 15%) and CYP1A2 (show CYP1A2 Proteins) (3.7% approximately 7.5%).
There were no significant differences in the bosutinib C0 between genotypes for ABCB1 (show ABCB1 Proteins), ABCG2, and CYP3A4 polymorphisms.
These results suggest that human and marmoset P450 (show CYP2B6 Proteins) 3A4/90 and 4F12 in livers or small intestines played important roles in terfenadine t-butyl hydroxylation. Marmosets could be a model for humans during first pass extraction of terfenadine and related substrates.
This first description of CYP3A4*20 null genotype in liver-transplanted patients, supports the relevance of CYP3A genotyping in tacrolimus therapy
We demonstrate for the first time that the effect of ABCB1 (show ABCB1 Proteins) diplotype on tacrolimus disposition is dependent on both CYP3A5 (show CYP3A5 Proteins) and CYP3A4 genotype.
Some flavonoids exhibit selective inhibition toward CYP3A4 rather than other major cytochromes. Here, data suggest high risk of herb-drug interactions or food-drug interactions could be caused by flavonoids; vital structural elements of natural flavonoids could lead to interactions with clinical drugs normally eliminated via CYP3A4 metabolism.
Patients with CYP2C19 (show CYP2C19 Proteins)*2 were at increased risk and CYP2C19 (show CYP2C19 Proteins)*2, CYP3A5 (show CYP3A5 Proteins)*3 and GSTP1 (show GSTP1 Proteins) have synergistic influence on CYC (show CYCS Proteins) failure.
The mAb concomitantly shifted IL-1beta (show IL1B Proteins) IC50 values towards CYP3A4 activity.
CYP3A4 was identified as a novel tumor suppressor gene related to a poor prognosis in HCC (show FAM126A Proteins).
In CYP3A4, the most energetically favorable docking mode places testosterone in a position with the methyl groups directed toward the heme iron

Horse (Equine) Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) interaction partners

It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase (show POR Proteins) and cytochrome b(5 (show CYB5A Proteins)).

CYP3A4 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist\; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with CYP3A4

cytochrome P450 family 3 subfamily A member 4 (CYP3A4)
cytochrome P450 3A4 (PTRG_01782)
cytochrome P450 3A4 (PTRG_06060)
cytochrome P450 family 3 subfamily A member 4 (cyp3a4)
cytochrome P450, subfamily IIIA, polypeptide 4 (CYP3A4)
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 (CYP3A4)
cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4)

CP33 protein
CP34 protein
CYP3A protein
CYP3A3 protein
CYP3A4 protein
CYP3A12 protein
CYP3A21 protein
CYP3A80 protein
CYPIIIA3 protein
CYPIIIA4 protein
CYPIIIA21 protein
HLP protein
MGC108372 protein
NF-25 protein
P450C3 protein
P450PCN1 protein

Protein level used designations for CYP3A4

, , , , , , , , , , , , , , , , , , , 1,8-cineole 2-exo-monooxygenase P450-III, steroid inducible albendazole monooxygenase albendazole sulfoxidase cytochrome P450 3A3 cytochrome P450 3A4 cytochrome P450 HLp cytochrome P450 NF-25 cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 cytochrome P450-PCN1 glucocorticoid-inducible P450 nifedipine oxidase quinine 3-monooxygenase taurochenodeoxycholate 6-alpha-hydroxylase cytochrome P450, family 3, subfamily A, polypeptide 4 cytochrome P450 3A80 Cytochrome P450 CM3A-10 cytochrome P450 3A21 cytochrome P450 CYP3A12

GENE ID	SPECIES
1576	Homo sapiens
6339762	Pyrenophora tritici-repentis Pt-1C-BFP
6344316	Pyrenophora tritici-repentis Pt-1C-BFP
548503	Xenopus (Silurana) tropicalis
416477	Gallus gallus
463582	Pan troglodytes
507988	Bos taurus
100037189	Xenopus laevis
100294525	Equus caballus
100404344	Callithrix jacchus
100462903	Macaca mulatta
479740	Canis lupus familiaris

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