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It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase (show POR Proteins) and cytochrome b(5 (show CYB5A Proteins)).
This study has identified 4 synonymous variants in the HCN4 (show HCN4 Proteins) gene and 3 SNPs in the CYP3A4 gene. None of the variants appear to have a major effect on the reduction of HR produced by ivabradine.
Findings show that at allelic and genotypic level polymorphisms in CYP3A4 and CYP1A2 (show CYP1A2 Proteins) are significantly associated with a reduced risk of drug addiction in Chinese individuals.
Methylation status of cytosine in the CYP3A4 proximal promoter correlated with changes in developmental expression of mRNA.
Occupancy by modified histones was consistent with chromatin structural changes contributing to the mechanisms regulating CYP3A4 ontogeny.
Established the regression models for CYP3A4 and CYP2B6 (show CYP2B6 Proteins) inductions in human hepatocytes using azole compounds.
Hydroxyl metabolite (M3) of VX-509 which is formed via the aldehyde oxidase (show AOX1 Proteins) pathway is responsible for CYP3A4 inhibition.
CYP3A5 (show CYP3A5 Proteins) genotype has minimal impact on the probability of quetiapine target attainment of the 1-hour concentrations but a significant impact on the 12-hour concentrations.
In Silico Predictions of Drug - Drug Interactions Caused by CYP1A2 (show CYP1A2 Proteins), 2C9 and 3A4 Inhibition - a Comparative Study of Virtual Screening Performance
CYP3A4 expression and N-acetyl transferase 2 (show NAT2 Proteins) acetylator phenotype can better identify the patients with higher risk of adverse reactions and can facilitate the improvement of personalized clonazepam therapy and withdrawal regimen.
The dose-dependent FaFg of selective and dual CYP3A and/or P-gp (show ABCB4 Proteins) substrates was well predicted.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist\; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
cytochrome P450 3A4
, cytochrome P450, family 3, subfamily A, polypeptide 4
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
, Cytochrome P450 CM3A-10
, cytochrome P450 3A21
, 1,8-cineole 2-exo-monooxygenase
, P450-III, steroid inducible
, albendazole monooxygenase
, albendazole sulfoxidase
, cytochrome P450 3A3
, cytochrome P450 HLp
, cytochrome P450 NF-25
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
, cytochrome P450-PCN1
, glucocorticoid-inducible P450
, nifedipine oxidase
, quinine 3-monooxygenase
, taurochenodeoxycholate 6-alpha-hydroxylase
, cytochrome P450 CYP3A12
, cytochrome P450 3A80