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It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase (show POR Proteins) and cytochrome b(5 (show CYB5A Proteins)).
The results demonstrated the important role of the CYP (show PPIG Proteins) 3A4*1B allelic variant as risk factor for developing resistance to antiepileptic drugs in pediatric patients with epilepsy
The established method provides a sensitive tool to evaluate the CYP3A4 protein in human liver homogenates from patients with normal or chronic/severe hepatic injury.
None of the patients with Regorafenib-induced severe toxic hepatitis had CYP3A4 gene mutations. Similar polymorphisms in UGT1A9 (show UGT1A9 Proteins) gene promoter region were found in both patients who presented acute hepatitis.
We sought to determine the relation between 17-alpha hydroxyprogesterone caproate plasma concentrations, progesterone receptor (show PGR Proteins) single nucleotide polymorphisms and single nucleotide polymorphisms in CYP3A4 and CYP3A5 (show CYP3A5 Proteins) and spontaneous preterm birth.
homozygous AA carriers of the CYP3A4 gene respond better to treatment with transdermal buprenorphine for critical limb ischemia
Data suggest that metabolism (and possibly pharmacokinetics) of hypnotic nitrazepam involves liver enzymes AOX1 (aldehyde oxidase 1 (show AOX1 Proteins)), NAT2 (N-acetyltransferase 2 (show NAT2 Proteins)), AADAC (arylacetamide deacetylase (show AADAC Proteins)), and CYP3A4 (cytochrome P450 3A4).
Cross-talk between pregnane X receptor (show NR1I2 Proteins) and AhR (show AHR Proteins) plays a role in rifampicin regulation of CYP3A4 gene expression.
We observed an association between ABCB1 (show ABCB1 Proteins) 3435 T/T and lower grade of toxicities (p=0.05) in patients receiving taxanes for breast cancer. No other associations were found for CYP (show PPIG Proteins) 3A4 *1B, 3A5*3 and ABCB1 (show ABCB1 Proteins) C1236T.
The authors found a correlation between genetic SNP variations in CYP3A4 enzyme and tacrolimus blood levels in this Jordanian kidney transplant recipients.
Hypertension is more likely to occur in A-allele carriers of the CYP3A4 rs4646437 variant in a cohort of metastatic renal carcinoma patients treated with sunitinib.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist\; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
cytochrome P450 3A4
, cytochrome P450, family 3, subfamily A, polypeptide 4
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
, Cytochrome P450 CM3A-10
, cytochrome P450 3A21
, 1,8-cineole 2-exo-monooxygenase
, P450-III, steroid inducible
, albendazole monooxygenase
, albendazole sulfoxidase
, cytochrome P450 3A3
, cytochrome P450 HLp
, cytochrome P450 NF-25
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
, cytochrome P450-PCN1
, glucocorticoid-inducible P450
, nifedipine oxidase
, quinine 3-monooxygenase
, taurochenodeoxycholate 6-alpha-hydroxylase
, cytochrome P450 CYP3A12
, cytochrome P450 3A80