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It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase (show POR Proteins) and cytochrome b(5 (show CYB5A Proteins)).
our findings suggest that CYP1A2 (show CYP1A2 Proteins), CYP3A4 and CYP3A5 (show CYP3A5 Proteins) play an important role in osteosarcoma tumorigenesis, at primary and metastatic sites, as well in treatment response
Our results provide information on CYP3A4 polymorphisms in Tibetan individuals which may help to optimize pharmacotherapy effectiveness by providing personalized medicine to this ethnic group.
Among two SNPs in CYP3A4 and CYP3A5 (show CYP3A5 Proteins) and 12 SNPs in ABCB1 (show ABCB1 Proteins) gene, an association with ovarian cancer risk was observed for ABCB1 (show ABCB1 Proteins) rs2157926 SNP only.
Low CYP3A4 Activity is associated with Crohn's Disease.
Cryopreserved human hepatocytes can be stored stably for more than a decade with little or no change in CYP3A4/5 induction.
Associations between SLCO1B1 (show SLCO1B1 Proteins) 521C and cholesterol response were not detected in African Americans (n = 333). Associations between CYP3A4*22 or CYP3A5 (show CYP3A5 Proteins)*3 and cholesterol response were not detected in whites or African Americans.
This kdeg value for CYP3A4 was in good agreement with recently reported values.
Sorafenib was poorly tolerated, and anti-Kaposi sarcoma (KS)activity was modest. Strong CYP3A4 inhibitors may contribute to sorafenib toxicity, and ritonavir has previously been shown to be a CYP3A4 inhibitor. Alternate antiretroviral agents without predicted interactions should be used when possible for concurrent administration with sorafenib
This study has identified 4 synonymous variants in the HCN4 (show HCN4 Proteins) gene and 3 SNPs in the CYP3A4 gene. None of the variants appear to have a major effect on the reduction of HR produced by ivabradine.
Findings show that at allelic and genotypic level polymorphisms in CYP3A4 and CYP1A2 (show CYP1A2 Proteins) are significantly associated with a reduced risk of drug addiction in Chinese individuals.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist\; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
cytochrome P450 3A4
, cytochrome P450, family 3, subfamily A, polypeptide 4
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
, Cytochrome P450 CM3A-10
, cytochrome P450 3A21
, 1,8-cineole 2-exo-monooxygenase
, P450-III, steroid inducible
, albendazole monooxygenase
, albendazole sulfoxidase
, cytochrome P450 3A3
, cytochrome P450 HLp
, cytochrome P450 NF-25
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
, cytochrome P450-PCN1
, glucocorticoid-inducible P450
, nifedipine oxidase
, quinine 3-monooxygenase
, taurochenodeoxycholate 6-alpha-hydroxylase
, cytochrome P450 CYP3A12
, cytochrome P450 3A80