Browse our CYP3A4 Proteins (CYP3A4)

Full name:: Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Proteins (CYP3A4)

On www.antibodies-online.com are 6 Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) Proteins from 5 different suppliers available. Additionally we are shipping CYP3A4 Antibodies (135) and CYP3A4 Kits (37) and many more products for this protein. A total of 189 CYP3A4 products are currently listed.

Synonyms:: CP33, CP34, CYP3A, CYP3A3, CYP3A4, CYP3A12, CYP3A21, CYP3A80, CYPIIIA3, CYPIIIA4, CYPIIIA21, HLP, MGC108372, NF-25, P450C3, P450PCN1

list all proteins	Gene Name	GeneID	UniProt
	CYP3A4	1576	P08684
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CYP3A4 Proteins (CYP3A4) by Origin

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Relevant Pathways for CYP3A4 Proteins

Steroid Hormone Biosynthesis

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More Proteins for CYP3A4 Interaction Partners

Horse (Equine) Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) interaction partners

It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase (show POR Proteins) and cytochrome b(5 (show CYB5A Proteins)).

Human Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) interaction partners

our findings suggest that CYP1A2 (show CYP1A2 Proteins), CYP3A4 and CYP3A5 (show CYP3A5 Proteins) play an important role in osteosarcoma tumorigenesis, at primary and metastatic sites, as well in treatment response
Our results provide information on CYP3A4 polymorphisms in Tibetan individuals which may help to optimize pharmacotherapy effectiveness by providing personalized medicine to this ethnic group.
Among two SNPs in CYP3A4 and CYP3A5 (show CYP3A5 Proteins) and 12 SNPs in ABCB1 (show ABCB1 Proteins) gene, an association with ovarian cancer risk was observed for ABCB1 (show ABCB1 Proteins) rs2157926 SNP only.
Low CYP3A4 Activity is associated with Crohn's Disease.
Cryopreserved human hepatocytes can be stored stably for more than a decade with little or no change in CYP3A4/5 induction.
Associations between SLCO1B1 (show SLCO1B1 Proteins) 521C and cholesterol response were not detected in African Americans (n = 333). Associations between CYP3A4*22 or CYP3A5 (show CYP3A5 Proteins)*3 and cholesterol response were not detected in whites or African Americans.
This kdeg value for CYP3A4 was in good agreement with recently reported values.
Sorafenib was poorly tolerated, and anti-Kaposi sarcoma (KS)activity was modest. Strong CYP3A4 inhibitors may contribute to sorafenib toxicity, and ritonavir has previously been shown to be a CYP3A4 inhibitor. Alternate antiretroviral agents without predicted interactions should be used when possible for concurrent administration with sorafenib
This study has identified 4 synonymous variants in the HCN4 (show HCN4 Proteins) gene and 3 SNPs in the CYP3A4 gene. None of the variants appear to have a major effect on the reduction of HR produced by ivabradine.
Findings show that at allelic and genotypic level polymorphisms in CYP3A4 and CYP1A2 (show CYP1A2 Proteins) are significantly associated with a reduced risk of drug addiction in Chinese individuals.

CYP3A4 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist\; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with CYP3A4

cytochrome P450 3A4 (PTRG_01782)
cytochrome P450 3A4 (PTRG_06060)
cytochrome P450 family 3 subfamily A member 4 (cyp3a4)
cytochrome P450 family 3 subfamily A member 4 (CYP3A4)
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 (CYP3A4)
cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4)
cytochrome P450, subfamily IIIA, polypeptide 4 (CYP3A4)

CP33 protein
CP34 protein
CYP3A protein
CYP3A3 protein
CYP3A4 protein
CYP3A12 protein
CYP3A21 protein
CYP3A80 protein
CYPIIIA3 protein
CYPIIIA4 protein
CYPIIIA21 protein
HLP protein
MGC108372 protein
NF-25 protein
P450C3 protein
P450PCN1 protein

Protein level used designations for CYP3A4

, , , , , , , , , , , , , , , , , , , cytochrome P450 3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 Cytochrome P450 CM3A-10 cytochrome P450 3A21 1,8-cineole 2-exo-monooxygenase P450-III, steroid inducible albendazole monooxygenase albendazole sulfoxidase cytochrome P450 3A3 cytochrome P450 HLp cytochrome P450 NF-25 cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 cytochrome P450-PCN1 glucocorticoid-inducible P450 nifedipine oxidase quinine 3-monooxygenase taurochenodeoxycholate 6-alpha-hydroxylase cytochrome P450 CYP3A12 cytochrome P450 3A80

GENE ID	SPECIES
6339762	Pyrenophora tritici-repentis Pt-1C-BFP
6344316	Pyrenophora tritici-repentis Pt-1C-BFP
548503	Xenopus (Silurana) tropicalis
463582	Pan troglodytes
100037189	Xenopus laevis
100294525	Equus caballus
100404344	Callithrix jacchus
100462903	Macaca mulatta
1576	Homo sapiens
479740	Canis lupus familiaris
416477	Gallus gallus
507988	Bos taurus

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