Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
We demonstrate for the first time that the effect of ABCB1 (show ABCB1 Proteins) diplotype on tacrolimus disposition is dependent on both CYP3A5 (show CYP3A5 Proteins) and CYP3A4 genotype.
Some flavonoids exhibit selective inhibition toward CYP3A4 rather than other major cytochromes. Here, data suggest high risk of herb-drug interactions or food-drug interactions could be caused by flavonoids; vital structural elements of natural flavonoids could lead to interactions with clinical drugs normally eliminated via CYP3A4 metabolism.
Patients with CYP2C19 (show CYP2C19 Proteins)*2 were at increased risk and CYP2C19 (show CYP2C19 Proteins)*2, CYP3A5 (show CYP3A5 Proteins)*3 and GSTP1 (show GSTP1 Proteins) have synergistic influence on CYC (show CYCS Proteins) failure.
The mAb concomitantly shifted IL-1beta (show IL1B Proteins) IC50 values towards CYP3A4 activity.
CYP3A4 was identified as a novel tumor suppressor gene related to a poor prognosis in HCC (show FAM126A Proteins).
In CYP3A4, the most energetically favorable docking mode places testosterone in a position with the methyl groups directed toward the heme iron
this study indicates that CYP3A activity is regained subsequent to kidney transplantation
Younger age, POR (show POR Proteins)*28 allele, and CYP3A5 (show CYP3A5 Proteins)*3 allele were associated with higher cyclosporine dosing requirements and lower concentration/dose ratio.
Single nucleotide polymorphism rs4646437 in CYP3A4 at 7q21.1 (p = .0325), associated with alpha-adrenergic receptor antagonist drug effect in Benign Prostatic Hyperplasia.
CYP3A4*1B is associated with CsA (show ERCC8 Proteins) C0/Dose ratio in renal transplant recipients which indicates patients with CYP3A4*1B allele require lower dose of CsA (show ERCC8 Proteins) to reach target blood concentration compared with the CYP3A4*1 carriers.[meta-analysis]
It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase (show POR Proteins) and cytochrome b(5 (show CYB5A Proteins)).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist\; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
, P450-III, steroid inducible
, albendazole monooxygenase
, albendazole sulfoxidase
, cytochrome P450 3A3
, cytochrome P450 3A4
, cytochrome P450 HLp
, cytochrome P450 NF-25
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
, cytochrome P450-PCN1
, glucocorticoid-inducible P450
, nifedipine oxidase
, quinine 3-monooxygenase
, taurochenodeoxycholate 6-alpha-hydroxylase
, cytochrome P450, family 3, subfamily A, polypeptide 4
, cytochrome P450 3A80
, Cytochrome P450 CM3A-10
, cytochrome P450 3A21
, cytochrome P450 CYP3A12