anti-HSD11B2 Antibodies

Protein Summary

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

Alternative names and synonyms associated with HSD11B2

• hydroxysteroid (11-beta) dehydrogenase 2 L homeolog (hsd11b2.L) antibody
• hydroxysteroid 11-beta dehydrogenase 2 (HSD11B2) antibody
• hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2) antibody

• 11-HSD2 antibody
• 11HSD2 antibody
• AME antibody
• AME1 antibody
• HSD2 antibody
• Show all synonym aliases
• HSD11B2 antibody
• HSD11K antibody
• MGC81883 antibody
• SDR9C3 antibody

Protein level used designations for HSD11B2

hydroxysteroid (11-beta) dehydrogenase 2 , corticosteroid 11-beta-dehydrogenase isozyme 2 , 11 beta-hydroxysteroid dehydrogenase type 2 , -HSD11 type II , 11-DH2 , 11-beta-HSD2 , 11-beta-hydroxysteroid dehydrogenase type 2 , 11-beta-hydroxysteroid dehydrogenase type II , NAD-dependent 11-beta-hydroxysteroid dehydrogenase , short chain dehydrogenase/reductase family 9C member 3 , 11-beta hydroxysteroid dehydrogenase , hydroxysteroid 11-beta dehydrogenase 2 , 11-beta-hydroxysteroid dehydrogenase 2 , 11(beta)-HSD2 , Hydroxysteroid dehydrogenase, 11 beta type 2