Browse our anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) Antibodies

Human Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

1. Six sequence variations were observed. Four mutations were indicated in the coding region of HSD11B2 and the other two in 3'-UTR (show UTS2R Antibodies). Two SNPs: c.468C > A and c.534G > A were found to be in total disequilibrium. High variability in HSD11B2 sequence was indicated in the study population, but the relevance of observed SNPs to gestational hypertension or pre-eclampsia development was not confirmed.

2. the role of 11beta-HSD2 in determining birth weight

3. SUMOylation of 11beta-HSD2 at residue K266 modulates cortisol-mediated MR nuclear translocation independently of effects on transactivation.

4. 11beta-HSD2 activity is not reduced in patients with drug resistant hypertension, suggesting that variation in the conversion of cortisol to cortisone does not contribute to development of antihypertensive treatment resistance.

5. The data demonstrate for the first time that 11b- HSD2 plays a key role in the pathophysiology of malignant epidermal cells.

6. DNA sequence analysis of affected members of Apparent mineralocorticoid excess family revealed homozygous c.799A>G mutations within exon 4 of HSD11B2, corresponding to a p.T267A mutation of 11betaHSD2.

7. activation of Hedgehog (show SHH Antibodies) signaling is crucial for the upregulation and maintenance of 11beta-HSD2 expression in placenta

8. Reciprocal regulation of the glucocorticoid metabolizing enzymes, 11beta-hydroxysteroid dehydrogenase types 1 and 2, is associated with steroid-responsiveness and disease remission in childhood nephrotic syndrome.

9. Rac1 GTPase (show RACGAP1 Antibodies) regulates 11beta-HSD2 expression, mineralocorticoid receptor (show NR3C2 Antibodies) activation, and mineralocorticoid receptor (show NR3C2 Antibodies)-mediated pro-fibrotic signaling.

10. enhancer of zeste homolog 2 (EZH2 (show EZH2 Antibodies)) accounts for the silence of 11beta-HSD2 expression via trimethylation of histone H3 (show HIST3H3 Antibodies) lysine 27 at the promoter of the 11beta-HSD2 gene.

Pig (Porcine) Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

1. These results indicate that the effects of maternal protein restriction on placental 11beta-HSD2 expression are gender-dependent in the pig, and thyroid hormones may be involved in such effects.

2. Postnatal ontogeny of 11beta-HSD2 gene expression is described for the first time in stress-related brain regions of domestic pigs at 7, 21, and 35 days of age.

3. concluded that the 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 (show HSD11B1 Antibodies) and 2) system is involved in the regulation of cortisol activity in the testis and thus in the regulation of spermatogenesis

4. Effects of age, weaning and/or social isolation on the expression of genes regulating HSD11B2.

5. The expression of 11beta-HSD2 in several types of cells forms consecutive lines of defense may protect spermatogonia against glucocorticoid-induced apoptosis.

6. 11beta-HSD (show HAL Antibodies) type 2, which is abundantly expressed, plays important roles in cortisol inactivation in pig Leydig cells.

7. The amount of 11beta-HSD 2 in germ cells was greatest at birth, decreased thereafter and was absent after Week 3.

Cow (Bovine) Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

1. investigation of expression for 11HSD1, 11HSD2, and glucocorticoid receptor (show NR3C1 Antibodies) during follicular maturation and atresia: in atretic follicles, expression of 11HSD2 increased in both granulosa cells and theca interna layers

Mouse (Murine) Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

1. Kidney-specific deficiency of 11beta-HSD2 leads to Salt-dependent Hypertension, which is attributed to mineralocorticoid receptor (show NR3C2 Antibodies)-epithelial sodium channel-Na(+)-Cl(-) cotransporter (show SLC12A3 Antibodies) activation in the kidney.

2. Rac1 GTPase (show RACGAP1 Antibodies) regulates 11beta-HSD2 expression, mineralocorticoid receptor (show NR3C2 Antibodies) activation, and mineralocorticoid receptor (show NR3C2 Antibodies)-mediated pro-fibrotic signaling.

3. Nr3c2 (show NR3C2 Antibodies) has a role in mouse skin development in a process that involves HSD11B1 (show HSD11B1 Antibodies)/HSD11B2

4. Reduced brain 11betaHSD2 promotes a hunger for salt and salt sensitivity. 11betaHSD2-positive neurons integrate salt appetite and the blood pressure response to dietary sodium through a mineralocorticoid receptor (show NR3C2 Antibodies)-dependent pathway.

5. 11betaHSD2 inhibition suppressed lung tumor growth and invasion in association with increased tissue active glucocorticoid levels, decreased COX-2 (show COX2 Antibodies) expression, inhibition of ERK (show EPHB2 Antibodies) and mTOR (show FRAP1 Antibodies) signaling pathways.

6. results show that intestinal epithelial 11ssHSD2 activity contributes to increased COX-2 (show COX2 Antibodies) expression in Apc (show APC Antibodies)+/min intestinal adenomas and that 11ssHSD2 deficiency in intestinal epithelial cells suppresses adenoma development and growth

7. 11beta-hydroxysteroid dehydrogenase-2 is a cortisol-inactivating enzyme with a role in keratinocyte cell proliferation and basal cell proliferation

8. Reduced 11beta-hydroxysteroid dehydrogenase type 2 causes salt sensitivity of blood pressure because of impaired renal natriuretic capacity.

9. findings implicate DNA methylation (show HELLS Antibodies) as a mechanism by which prenatal stress alters HSD11B2 gene expression

10. This study found that 11beta-hydroxysteroid dehydrogenase type 2 knockout mice develop nephrogenic diabetes insipidus (show AVPR2 Antibodies).