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|Antigen||Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) Antibodies|
|Epitope||Extracellular Domain Alternatives|
|Reactivity||Human, Rat (Rattus), Mouse (Murine) Alternatives|
|Conjugate||This GRIN1 antibody is un-conjugated Alternatives|
Immunohistochemistry (IHC), Western Blotting (WB)
Product Details anti-GRIN1 AntibodyTarget Details GRIN1 Application Details Handling Images
|Specificity||Specific for NMDAR1.|
|Immunogen||A synthetic peptide from extracellular domain of mouse NMDAR1 (GRIN1) conjugated to an immunogenic carrier protein was used as the antigen.|
|Plasmids, Primers & others|
Target Details GRIN1Product Details anti-GRIN1 Antibody Application Details Handling Images back to top
|Alternative Name||NMDAR1 (GRIN1 Antibody Abstract)|
Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.
Subcellular location: Cell membrane, Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Note: Enriched in post-synaptic plasma membrane and post-synaptic densities Also known as: NMDZ1, Glutamate [NMDA] receptor subunit zeta-1, GRIN1.
|Pathways||Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity|
Application DetailsProduct Details anti-GRIN1 Antibody Target Details GRIN1 Handling Images back to top
A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
|Restrictions||For Research Use only|
HandlingProduct Details anti-GRIN1 Antibody Target Details GRIN1 Application Details Images back to top
|Reconstitution||Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.|
|Handling Advice||Avoid freeze and thaw cycles.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Expiry Date||12 months|
ImagesProduct Details anti-GRIN1 Antibody Target Details GRIN1 Application Details Handling back to top