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anti-Human Aurora Kinase B Antibodies:
anti-Mouse (Murine) Aurora Kinase B Antibodies:
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Human Polyclonal Aurora Kinase B Primary Antibody for ICC, IF - ABIN151760
Adams, Eckley, Vagnarelli, Wheatley, Gerloff, Mackay, Svingen, Kaufmann, Earnshaw: Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. in Chromosoma 2001
Show all 11 Pubmed References
Human Monoclonal Aurora Kinase B Primary Antibody for IF, WB - ABIN968357
Chen, Jin, Tahir, Zhang, Liu, Sarthy, McGonigal, Liu, Rosenberg, Ng: Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells. in The Journal of biological chemistry 2002
Show all 5 Pubmed References
Human Monoclonal Aurora Kinase B Primary Antibody for IF, WB - ABIN968358
Lange, Rebollo, Herold, González: Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes. in The EMBO journal 2002
Show all 5 Pubmed References
Human Polyclonal Aurora Kinase B Primary Antibody for ICC, IF - ABIN152999
Qi, Tang, Yu: Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. in Molecular biology of the cell 2006
Show all 3 Pubmed References
Human Monoclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN965626
Song, So, Cheng, Tang, Croft: Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. in Immunity 2005
Show all 2 Pubmed References
Human Monoclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN1724660
Kapoor, Lavoie, Frappier: EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases. in Molecular and cellular biology 2005
Show all 2 Pubmed References
Human Polyclonal Aurora Kinase B Primary Antibody for EIA, WB - ABIN117978
Honda, Asato, Tanaka, Endo, Nishimura, Ito: Vidian nerve schwannoma with middle cranial fossa extension resected via a maxillary swing approach. in Head & neck 2008
Show all 9 Pubmed References
Human Polyclonal Aurora Kinase B Primary Antibody for ICC, IF - ABIN408113
Togashi, Shirakawa, Orime, Kaji, Sakamoto, Tajima, Inoue, Nakamura, Tochino, Goshima, Shimomura, Terauchi: β-Cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice. in Endocrinology 2014
Chimpanzee Polyclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN2477557
Klever, Grond-Ginsbach, Hager, Schroeder-Kurth: Chorionic villus metaphase chromosomes and interphase nuclei analysed by chromosomal in situ suppression (CISS) hybridization. in Prenatal diagnosis 1992
Show all 2 Pubmed References
Human Polyclonal Aurora Kinase B Primary Antibody for WB - ABIN2441645
Bailey, Fields, Cheng, Lee, Wagenaar, Lagrois, Schmidt, Xia, Ma: WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission. in The Journal of biological chemistry 2015
Aurora A (show AURKA Antibodies) and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Regulation of Polo (show PLK1 Antibodies) by Aurora B and Map205 is required for cytokinesis.
We propose that mutual inhibitions between Aurora B a (show CDK1 Antibodies)nd Cyclin B regulate the duration of abscission and thereby the number of sister cells in each cyst.
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
Aurora B interacts with and requires the Cdc37 (show CDC37 Antibodies)/Hsp90 (show HSP90 Antibodies) complex for its stability.
INCENP (show INCENP Antibodies) binds to the cohesion protector protein (show PRDX2 Antibodies) MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Identification and characterization of AURKB and AURKC (show AURKC Antibodies) variants associated with maternal aneuploidy has been reported.
SIX3 is a novel negative transcriptional regulator and acts as a tumor suppressor that directly represses the transcription of AURKA (show AURKA Antibodies) and AURKB in astrocytoma.
Our findings suggested that AURKA (show AURKA Antibodies) (rs911160) and AURKB (rs2289590) polymorphisms could affect GC risk. Further validation studies in larger and multi-ethnical populations are needed to elucidate their functional impact on the development of GC
Data show that aurora-B regulates end-on conversion in human cells and indicate a late role for SPAG5 (show SPAG5 Antibodies) protein (Astrin (show SPAG5 Antibodies))-SKAP (show KNSTRN Antibodies) complex in the end-on conversion process.
The results of experiment indicated that specific knockdown of Aurora kinase B led to prostate carcinoma cells apoptosis and inhibited tumor growth.
decrease in Aurora B results in diminished binding of the chromokinesin Kif4A to chromosome arms.
Aurora B kinase interacts with and phosphorylates Sgo1 (show SGOL1 Antibodies). Aurora B-mediated phosphorylation of Sgo1 (show SGOL1 Antibodies) regulates the distribution of Sgo1 (show SGOL1 Antibodies) between centromeres and chromosome arms.
AURKC (show AURKC Antibodies) rs758099 TT and (CC + CT) genotypes were positively associated with increased intestinal type gastric cancer (GC)risk, but not with an increased diffuse type GC risk. Based on these results, we can conclude that AURKA (show AURKA Antibodies) rs1047972 and AURKC (show AURKC Antibodies) rs758099 polymorphisms could affect the risk of GC development.
Aurora-C (show AURKC Antibodies) interactions with members of the Chromosome Passenger Complex (CPC), Survivin (show BIRC5 Antibodies) and Inner Centromere Protein (INCENP (show INCENP Antibodies)) in reference to known Aurora-B interactions to understand the functional significance of Aurora-C (show AURKC Antibodies) overexpression in human cancer cells, is reported.
Aurora kinase (show AURKA Antibodies) inhibitor danusertib negatively regulated AURKB/p70S6K (show RPS6KB1 Antibodies)/RPL15 (show RPL15 Antibodies) axis with the involvement of PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies), AMPK (show PRKAA1 Antibodies), and p38 MAPK (show MAPK14 Antibodies) signaling pathways, leading to the induction of apoptosis and autophagy in human leukemia cells.
Loss of AURKB function affects TERF1 (show TERF1 Antibodies) telomere binding and results in aberrant telomere structure.
The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB or AURKC (show AURKC Antibodies) using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA (show AURKA Antibodies) expression is crucial for spindle formation in meiosis
Aurkb phosphorylates Oct4 (show POU5F1 Antibodies)(S229) during G2/M phase, leading to the dissociation of Oct4 (show POU5F1 Antibodies) from chromatin, whereas PP1 (show PPP1CC Antibodies) binds Oct4 (show POU5F1 Antibodies) and dephosphorylates Oct4 (show POU5F1 Antibodies)(S229) during M/G1 transition, which resets Oct4 (show POU5F1 Antibodies)-driven transcription for pluripotency and the cell cycle.
Overexpression of Aurora B (show AURKC Antibodies) also results in a reduced DNA damage response and decreased levels of the p53 (show TP53 Antibodies) target p21(Cip1 (show CDKN1A Antibodies)) in vitro and in vivo.
Chromsome stability is on of the tumor-suppressive functions of ARF as well as regulation of Aurora B (show AURKC Antibodies) expression in tumors.
Using this mutant we show for the first time that AURKC has functions that do not overlap with AURKB. These functions include regulating localized CPC activity and regulating chromosome alignment and K-MT attachments at metaphase of meiosis I (Met I).
reduced accumulation of Aurora B (show AURKC Antibodies) at the inner centromere region in cells lacking Pds5B (show PDS5B Antibodies) impairs its error correction function, promoting chromosome mis (show AMH Antibodies)-segregation and aneuploidy
Aurora B (show AURKC Antibodies) and Ring1B (show RNF2 Antibodies) co-occupy active promoters in resting lymphocytes.
FBXL2 (show FBXL2 Antibodies) mediates Aurora B (show AURKC Antibodies) ubiquitination and degradation within the midbody, which is sufficient to induce mitotic arrest and apoptosis.
Inhibitions of Aurora B (show AURKC Antibodies) and Cyclin-dependent kinase 1 (show CDK1 Antibodies) activity in vertebrate cells also have opposite effects on the timing of abscission.
Alterations in PGRMC1 (show PGRMC1 Antibodies) and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts.
AURKB associated with metaphase chromosomes.
Aurora B kinase is essential for furrow induction and maturation in the zebrafish embryo.
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene.
, aurora B
, aurora B kinase
, dAurora B
, aurora/IPL1-related kinase 2
, serine/threonine-protein kinase 12
, serine/threonine-protein kinase aurora-B
, aurora kinase B
, serine/threonine-protein kinase 12-like
, aurora 1
, aurora kinase B-Sv1
, aurora kinase B-Sv2
, aurora- and Ipl1-like midbody-associated protein 1
, aurora-related kinase 2
, protein phosphatase 1, regulatory subunit 48
, serine/threonine kinase 12
, serine/threonine-protein kinase 5
, aurora- and IPL1-like midbody-associated protein 1
, serine/threonine kinase 5
, Serine/threonine-protein kinase 12
, cellular island
, serine/threonine kinase a
, I-kappa-B kinase 2
, I-kappa-B-kinase beta
, inhibitor of kappaB kinase beta
, inhibitor of nuclear factor kappa B kinase beta subunit
, inhibitor of nuclear factor kappa-B kinase subunit beta
, nuclear factor NF-kappa-B inhibitor kinase beta