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anti-Human Aurora Kinase B Antibodies:
anti-Mouse (Murine) Aurora Kinase B Antibodies:
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Human Polyclonal Aurora Kinase B Primary Antibody for ICC, IF - ABIN151760
Adams, Eckley, Vagnarelli, Wheatley, Gerloff, Mackay, Svingen, Kaufmann, Earnshaw: Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. in Chromosoma 2001
Show all 11 Pubmed References
Human Polyclonal Aurora Kinase B Primary Antibody for ICC, IF - ABIN152999
Qi, Tang, Yu: Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. in Molecular biology of the cell 2006
Show all 3 Pubmed References
Human Monoclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN965626
Song, So, Cheng, Tang, Croft: Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. in Immunity 2005
Show all 2 Pubmed References
Human Monoclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN1724660
Kapoor, Lavoie, Frappier: EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases. in Molecular and cellular biology 2005
Show all 2 Pubmed References
Human Polyclonal Aurora Kinase B Primary Antibody for EIA, WB - ABIN117978
Honda, Asato, Tanaka, Endo, Nishimura, Ito: Vidian nerve schwannoma with middle cranial fossa extension resected via a maxillary swing approach. in Head & neck 2008
Show all 9 Pubmed References
Human Polyclonal Aurora Kinase B Primary Antibody for ICC, IF - ABIN408113
Togashi, Shirakawa, Orime, Kaji, Sakamoto, Tajima, Inoue, Nakamura, Tochino, Goshima, Shimomura, Terauchi: β-Cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice. in Endocrinology 2014
Chimpanzee Polyclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN2477557
Klever, Grond-Ginsbach, Hager, Schroeder-Kurth: Chorionic villus metaphase chromosomes and interphase nuclei analysed by chromosomal in situ suppression (CISS) hybridization. in Prenatal diagnosis 1992
Show all 2 Pubmed References
Human Polyclonal Aurora Kinase B Primary Antibody for WB - ABIN2441645
Bailey, Fields, Cheng, Lee, Wagenaar, Lagrois, Schmidt, Xia, Ma: WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission. in The Journal of biological chemistry 2015
Human Polyclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN129612
Mackay, Makise, Ullman: Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint. in The Journal of cell biology 2010
The data suggest that AKA (show NEUROG1 Antibodies) is the vertebrate ancestral gene, and that AKB and AKC resulted from gene duplication in placental mammals.
Study reveals the mechanism controlling abscission through integration of Aurora B kinase and B56-bound PP2A (show PPP2R4 Antibodies) phosphatase activities on the kinesin motor protein (show KIF16B Antibodies) MKlp2 (show KIF20A Antibodies). MKlp2 (show KIF20A Antibodies) is an essential protein for promoting abscission, which may regulate tethering and stabilizing of the PM to the microtubule cytoskeleton at the intercellular bridge through its previously uncharacterized lipid association motif.
we identified deguelin as an effective Aurora B inhibitor, which deserves further studies in other animal models and esophageal squamous cell carcinoma treatment
Our data show that S49076 exerts its cytotoxic activity at low doses on MET-dependent cells through MET inhibition, whereas it inhibits growth of MET-independent cells at higher but clinically relevant doses by targeting Aurora B
Results show the overexpression Aurkb decreased glycolytic activities and suggest that AURKB is involved in asthenozoospermia.
Identification and characterization of AURKB and AURKC (show AURKC Antibodies) variants associated with maternal aneuploidy has been reported.
SIX3 is a novel negative transcriptional regulator and acts as a tumor suppressor that directly represses the transcription of AURKA (show AURKA Antibodies) and AURKB in astrocytoma.
Our findings suggested that AURKA (show AURKA Antibodies) (rs911160) and AURKB (rs2289590) polymorphisms could affect GC risk. Further validation studies in larger and multi-ethnical populations are needed to elucidate their functional impact on the development of GC
Data show that aurora-B regulates end-on conversion in human cells and indicate a late role for SPAG5 (show SPAG5 Antibodies) protein (Astrin (show SPAG5 Antibodies))-SKAP (show KNSTRN Antibodies) complex in the end-on conversion process.
The results of experiment indicated that specific knockdown of Aurora kinase B led to prostate carcinoma cells apoptosis and inhibited tumor growth.
Data show that phosphorylated Ku70 (show XRCC6 Antibodies) S155 interacts with the Aurora B kinase and leads to inhibition of its activity.
Loss of AURKB function affects TERF1 (show TERF1 Antibodies) telomere binding and results in aberrant telomere structure.
The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB or AURKC (show AURKC Antibodies) using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA (show AURKA Antibodies) expression is crucial for spindle formation in meiosis
Aurkb phosphorylates Oct4 (show POU5F1 Antibodies)(S229) during G2/M phase, leading to the dissociation of Oct4 (show POU5F1 Antibodies) from chromatin, whereas PP1 (show PPP1CC Antibodies) binds Oct4 (show POU5F1 Antibodies) and dephosphorylates Oct4 (show POU5F1 Antibodies)(S229) during M/G1 transition, which resets Oct4 (show POU5F1 Antibodies)-driven transcription for pluripotency and the cell cycle.
Overexpression of Aurora B (show AURKC Antibodies) also results in a reduced DNA damage response and decreased levels of the p53 (show TP53 Antibodies) target p21(Cip1 (show CDKN1A Antibodies)) in vitro and in vivo.
Chromsome stability is on of the tumor-suppressive functions of ARF as well as regulation of Aurora B (show AURKC Antibodies) expression in tumors.
Using this mutant we show for the first time that AURKC has functions that do not overlap with AURKB. These functions include regulating localized CPC activity and regulating chromosome alignment and K-MT attachments at metaphase of meiosis I (Met I).
reduced accumulation of Aurora B (show AURKC Antibodies) at the inner centromere region in cells lacking Pds5B (show PDS5B Antibodies) impairs its error correction function, promoting chromosome mis (show AMH Antibodies)-segregation and aneuploidy
Aurora B (show AURKC Antibodies) and Ring1B (show RNF2 Antibodies) co-occupy active promoters in resting lymphocytes.
FBXL2 (show FBXL2 Antibodies) mediates Aurora B (show AURKC Antibodies) ubiquitination and degradation within the midbody, which is sufficient to induce mitotic arrest and apoptosis.
Aurora A (show AURKA Antibodies) and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Regulation of Polo (show PLK1 Antibodies) by Aurora B and Map205 is required for cytokinesis.
We propose that mutual inhibitions between Aurora B and Cyclin B regulate the duration of abscission and thereby the number of sister cells in each cyst.
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
Aurora B interacts with and requires the Cdc37 (show CDC37 Antibodies)/Hsp90 (show HSP90 Antibodies) complex for its stability.
INCENP (show INCENP Antibodies) binds to the cohesion protector protein (show PRDX2 Antibodies) MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Alterations in PGRMC1 (show PGRMC1 Antibodies) and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts.
AURKB associated with metaphase chromosomes.
Aurora B kinase is essential for furrow induction and maturation in the zebrafish embryo.
Data suggest a model in which microtubules act as scaffolds for the enzymatic activity of Aurora-B.
Data report the crystal structure of Aurora B in complex with the IN-box segment of the inner centromere protein (INCENP (show INCENP Antibodies)) activator and with the small molecule inhibitor Hesperadin.
ICIS (show MTUS1 Antibodies) and Aurora B coregulate the microtubule depolymerase Kif2a (show KIF2A Antibodies).
the Aurora B chromosome passenger protein complex, including INCENP (show INCENP Antibodies) and survivin, is regulated during oocyte maturation in Xenopus laevis
This study reveals a new role for Aurora B, which is to prevent excess MCAK (show KIF2C Antibodies) binding to chromatin to facilitate chromatin-nucleated spindle assembly.
MCAK (show KIF2C Antibodies) regulation of cytoplasmic and spindle-associated (show HAUS1 Antibodies) microtubules can be differentiated by Aurora B-dependent phosphorylation
results suggest an essential combined function of AurA (show AURKA Antibodies) and AurB in chromosome segregation and anaphase MT dynamics
Aurora B pathway is suppressed in the cytoplasm of Xenopus egg extract by phosphatases, but that it becomes activated by chromatin via a Ran-independent mechanism.
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene.
, aurora 1
, aurora kinase B-Sv1
, aurora kinase B-Sv2
, aurora- and Ipl1-like midbody-associated protein 1
, aurora-related kinase 2
, aurora/IPL1-related kinase 2
, protein phosphatase 1, regulatory subunit 48
, serine/threonine kinase 12
, serine/threonine-protein kinase 12
, serine/threonine-protein kinase 5
, serine/threonine-protein kinase aurora-B
, aurora B
, aurora- and IPL1-like midbody-associated protein 1
, serine/threonine kinase 5
, aurora B kinase
, dAurora B
, Serine/threonine-protein kinase 12
, cellular island
, serine/threonine kinase a
, aurora kinase B
, serine/threonine-protein kinase 12-like
, Aurora/IPL1-related kinase 2-B
, Serine/threonine-protein kinase 12-B
, Serine/threonine-protein kinase aurora-B-B
, aurora kinase B-B
, aurora/IPL1-related kinase 2-B
, serine/threonine-protein kinase 12-B
, serine/threonine-protein kinase aurora-B-B