Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
We conclude that downregulated CD3zeta confers a proinflammatory phenotype to systemic lupus erythematosus NK cells and contributes to their altered function in patients with systemic lupus erythematosus .
Data confirm previous findings that the CD247 polymorphisms are mainly associated with the clinical outcome of systemic lupus erythematosus and less with susceptibility.
analysis of the assembly and surface expression of FcepsilonR1alpha in cells shows that CD16A associates equally well with human CD247 and FcepsilonR1gamma homodimers
Long-term lung function decline in asthma is associated with elevation of bronchial CD8 and CD4 at baseline, and CD8, CD3 and granzyme B at follow-up
Crk-dependent increased phosphorylation of CD3zeta coincided with inhibition of TCR downmodulation, supporting a positive role for Crk adaptor proteins in TCR-mediated signal amplification.
the immunohistochemical staining patterns of CD3 and CD20 in Malignant Lymphoma Cells, were investigated.
CD274 up-regulation in new-onset type 1 diabetes mellitusis correlated with disease pathogenesis.
our observations suggested that CD247 gene polymorphism (rs858554) may associated with the susceptibility of RA.
CD3/28-activated T cells expanded in IL-7 and IL-15 produced greater expansion of memory stem T cells and central memory T cell-derived T cells compared with IL-2. Our strategy provides a powerful tool to elucidate the characteristics of CAR-modified T cells, regardless of the protocol used for expansion, reveals the functional properties of each expanded T cell subset.
Multiple mutations were found in CD247 complementary DNAs (cDNAs) cloned from the patient as well as in cDNA and genomic DNA from other individuals, suggesting that genetic variation in this gene is frequent.
Single-nucleotide polymorphism in CD247 gene is associated with sclerotic graft-versus-host disease.
CD3Z hypermethylation was significantly correlated with SLE. CD3Z hypermethylation is an SLE risk factor that can be modified by environmental factors and is associated with more severe SLE clinical manifestations, which are related to deranged T cell function by downregulating the CD3zeta-chain.
Linkage and association studies revealed a chromosomal region in which a novel type 1 diabetes (T1D)/autoimmune thyroid disease (AITD) susceptibility gene, CD247, is located and showed association between T1D/AITD and several variants in this gene. These results suggests that common susceptibility genes act in concert with variants of CD247 to generate genetic risk for T1D/AITD in this population.
Suggest 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-zeta chain down-regulation via caspase-3 activation in oral cancer.
SRSF1 regulates CD3zeta expression in human T cells and may contribute to the T cell defect in systemic lupus erythematosus.
In localized colorectal cancer carriers, mRNA-based CD3Z/CD8 profiling of tumor immune response may have stage, site and tissue-specific prognostic significance, along with ESR1 expression.
identified among the key genes in circulating monocytes that were altered by exercise
Our study independently confirms and extends the association of SLE with CD247, which is shared by various autoimmune disorders and supports a common T-cell-mediated mechanism.
we observed decreased CD3 surface expression, reduced ZAP-70 abundance and increased histone H3-acetylation in activated T lymphocytes after 5 minutes of clinorotation and a transient downregulation of CD3 and stable downregulation of IL-2R
T cell receptor (TCR)-CD3 complex and the Lck kinase were required for Ca(2+) mobilization but not for apoptosis induction in Jurkat cells.
ITAM sequence diversity is required for optimal TCR signal transduction and subsequent T cell maturation
Comprehensive Survey of miRNA-mRNA Interactions Reveals That Ccr7 and Cd247 (CD3 zeta) are Posttranscriptionally Controlled in Pancreas Infiltrating T Lymphocytes of Non-Obese Diabetic (NOD) Mice
There is an early (within seconds) interaction between CD3zeta and the coreceptor CD8 that is independent of the binding of CD8 to MHC.
The resting TCR localized in the disordered domain of giant plasma membrane (PM) vesicles (GPMVs) and PM spheres (PMSs) and single and nanoclustered TCRs are found in the high-density fractions in sucrose gradients.
When Ly108 is engaged in trans during cell-cell interactions, Ly108-CD3zeta interactions are promoted in a manner that uniquely depends on Ly108 TM domain, leading to more efficient CD3zeta dephosphorylation.
Two transcription factor binding sites and a long non-coding RNA are identified within the Cd247 gene.
Zfat-deficiency results in a loss of CD3zeta phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.
The results of this study supported the model that the procognitive function of CD3zeta may be mediated through its involvement in the NMDAR downstream signaling pathway leading to CaMKII-dependent LTP induction.
T cell CD3zeta deficiency enables multiorgan tissue inflammation.
Tyrosine phosphorylation of the TCR-zeta cytoplasmic domain regulates its association with the plasma membrane
The data of this study suggested that CD3zeta mediates the ZAP-70/Syk kinase activation triggered by ephrinA-activated pathway to regulate early neuronal morphogenesis.
Data show that TCRzeta phosphorylation signal pathways were affected in CD3gamma(-/-) primary and HVS-transformed T cells.
functional role for CD3 zeta basic-rich stretch -phosphoinositide interactions in supporting T cell activation
Results suggest that RhoH regulates TCR signaling via recruitment of ZAP-70 and Lck to CD3zeta in the immunological synapse.
an intracellular pool of phosphorylated CD3zeta may help to sustain TcR/CD3 signaling after the receptor internalization.
The allele of the Cd3zeta gene expressed in NOD and DBA/2 mouse strains confers lower levels of T cell activation compared with the allele expressed by C57BL/6, BALB/c, and C3H/HeJ mice.
GRAIL, by mediating TCR-CD3 degradation, regulates naive T cell tolerance induction and Treg cell function
a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs is required for effective iNKT cell development.
We show that CD3zeta is expressed in retinal ganglion cells (RGCs). CD3zeta-deficient mice have reduced RGC dendritic motility, an increase in RGC dendritic density, and a selective defect of glutamate-receptor-mediated synaptic activity in the retina.
Data show that In quiescent T cells, both TCR and Lat existed in separate membrane domains (protein islands), and these domains concatenated after T cell activation.
The structure of the adaptor protein cd3zeta has been identified in the zebrafish genome.
amino acid sequence and base sequence reported for the first time in the pig zeta chain and eta chain
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
CD247 antigen, zeta subunit
, CD3Z antigen, zeta polypeptide (TiT3 complex)
, CD3zeta chain
, T-cell antigen receptor complex, zeta subunit of CD3
, T-cell receptor T3 zeta chain
, T-cell surface glycoprotein CD3 zeta chain
, TCR zeta chain
, CD3 antigen, zeta polypeptide
, T-cell receptor T3 eta chain
, CD3 zeta
, CD247 molecule
, CD247 antigen
, T-cell receptor CD3 subunit zeta
, T-cell receptor CD3, subunit zeta
, CD3 zeta chain
, CD3 Zeta chain
, antigen CD3Z, zeta polypeptide
, T-cell receptor zeta chain