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The structure of the adaptor protein cd3zeta has been identified in the zebrafish genome.
ITAM sequence diversity is required for optimal TCR signal transduction and subsequent T cell maturation
Comprehensive Survey of miRNA-mRNA Interactions Reveals That Ccr7 (show CCR7 Proteins) and Cd247 (CD3 zeta) are Posttranscriptionally Controlled in Pancreas Infiltrating T Lymphocytes of Non-Obese Diabetic (NOD) Mice
There is an early (within seconds) interaction between CD3zeta and the coreceptor CD8 that is independent of the binding of CD8 to MHC.
The resting TCR localized in the disordered domain of giant plasma membrane (PM) vesicles (GPMVs) and PM spheres (PMSs) and single and nanoclustered TCRs are found in the high-density fractions in sucrose gradients.
When Ly108 (show SLAMF6 Proteins) is engaged in trans during cell-cell interactions, Ly108 (show SLAMF6 Proteins)-CD3zeta interactions are promoted in a manner that uniquely depends on Ly108 (show SLAMF6 Proteins) TM domain, leading to more efficient CD3zeta dephosphorylation.
Two transcription factor binding sites and a long non-coding RNA are identified within the Cd247 gene.
Zfat-deficiency results in a loss of CD3zeta phosphorylation with dysregulation of ERK (show EPHB2 Proteins) and Egr (show EGR1 Proteins) activities leading to impaired positive selection.
The results of this study supported the model that the procognitive function of CD3zeta may be mediated through its involvement in the NMDAR (show GRIN1 Proteins) downstream signaling pathway leading to CaMKII (show CAMK2G Proteins)-dependent LTP (show SCP2 Proteins) induction.
T cell CD3zeta deficiency enables multiorgan tissue inflammation.
Tyrosine phosphorylation of the TCR-zeta cytoplasmic domain regulates its association with the plasma membrane
CD274 (show CD274 Proteins) up-regulation in new-onset type 1 diabetes mellitusis correlated with disease pathogenesis.
our observations suggested that CD247 gene polymorphism (rs858554) may associated with the susceptibility of RA.
CD3 (show CD3 Proteins)/28-activated T cells expanded in IL-7 (show IL7 Proteins) and IL-15 (show IL15 Proteins) produced greater expansion of memory stem T cells and central memory T cell-derived T cells compared with IL-2 (show IL2 Proteins). Our strategy provides a powerful tool to elucidate the characteristics of CAR-modified T cells, regardless of the protocol used for expansion, reveals the functional properties of each expanded T cell subset.
Multiple mutations were found in CD247 complementary DNAs (cDNAs) cloned from the patient as well as in cDNA and genomic DNA from other individuals, suggesting that genetic variation in this gene is frequent.
Single-nucleotide polymorphism in CD247 gene is associated with sclerotic graft-versus-host disease.
CD3Z hypermethylation was significantly correlated with SLE. CD3Z hypermethylation is an SLE risk factor that can be modified by environmental factors and is associated with more severe SLE clinical manifestations, which are related to deranged T cell function by downregulating the CD3zeta-chain.
Linkage and association studies revealed a chromosomal region in which a novel type 1 diabetes (T1D)/autoimmune thyroid disease (AITD) susceptibility gene, CD247, is located and showed association between T1D/AITD and several variants in this gene. These results suggests that common susceptibility genes act in concert with variants of CD247 to generate genetic risk for T1D/AITD in this population.
Suggest 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-zeta chain down-regulation via caspase-3 (show CASP3 Proteins) activation in oral cancer.
SRSF1 (show SRSF1 Proteins) regulates CD3zeta expression in human T cells and may contribute to the T cell defect in systemic lupus erythematosus.
In localized colorectal cancer carriers, mRNA-based CD3Z/CD8 (show CD8A Proteins) profiling of tumor immune response may have stage, site and tissue-specific prognostic significance, along with ESR1 (show ESR1 Proteins) expression.
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
CD247 antigen like
, CD247 antigen-like
, T-cell surface glycoprotein CD3 zeta chain
, CD3 zeta
, CD247 molecule
, CD3 antigen, zeta polypeptide
, T-cell receptor T3 eta chain
, CD247 antigen, zeta subunit
, CD3Z antigen, zeta polypeptide (TiT3 complex)
, CD3zeta chain
, T-cell antigen receptor complex, zeta subunit of CD3
, T-cell receptor T3 zeta chain
, TCR zeta chain
, CD247 antigen
, T-cell receptor CD3 subunit zeta
, T-cell receptor CD3, subunit zeta
, CD3 zeta chain
, CD3 Zeta chain