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Tregs were observed to regulate CD4 (show CD4 Proteins)(+), but not CD8 (show CD8A Proteins)(+), T cell infiltration into tumors through a CTLA-4 (show CTLA4 Proteins)/CD80 dependent mechanism. Disrupting CTLA-4 (show CTLA4 Proteins) interaction with CD80 was sufficient to induce CD4 (show CD4 Proteins) T cell infiltration into tumors.
Results show that CD80 down-regulation is associated to aberrant DNA methylation (show HELLS Proteins) in dysplasia of sporadic colonic carcinogenesis. This study indicates that the failure of immune surveillance mechanisms in non-inflammatory colon carcinogenesis may be linked to genomic methylation directly or indirectly affecting CD80 expression.
CTLA-4 (show CTLA4 Proteins)(+) microvesicles can competitively bind B7 costimulatory molecules on bystander dendritic cells, resulting in downregulation of B7 surface expression.
The expression of B7-H6 (show NCR3LG1 Proteins) is up-regulated in U87-derived glioma stem like cells.
PD-1 (show PDCD1 Proteins) receptor has a role in interacting with programmed cell death ligands and B7-1
CD80-QPAR platform provides a useful predictive model for unknown RA extract's bioactivities using the chemical fingerprint inputs
this study shows that dendritic cells from rheumatoid arthritis patients have low expression levels of CD80
B7-1 is not expressed by podocytes in LN. A renoprotective effect of B7-1 blockade in LN patients cannot be ruled out but, if confirmed, cannot be the result of an effect on podocyte B7-1
analysis of CTLA4 (show CTLA4 Proteins)-Ig in B7-1-positive diabetic and non-diabetic kidney disease [review]
Genetic interaction of CD80 and ALOX5AP (show ALOX5AP Proteins) was observed in systemic lupus erythematosus in Asian populations.
TNFalpha (show TNF Proteins) is a prominent mediator of renal CD80 induction and resultant albuminuria.
findings do not support a role for B7-1 in podocyte biology
PD-L1 (show CD274 Proteins) interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8 (show CD8A Proteins)+ T cells
Meningococcal capsular polysaccharide-loaded vaccine nanoparticles induce expression of CD80.
The genetic inactivation of B7.1/B7.2 (show CD86 Proteins) deteriorates obesity-related liver steatosis and metabolic dysregulation, likely a result of the intrinsic absence of Tregs in these mice, rendering DKO mice a novel murine model of NASH (show SAMSN1 Proteins).
These results indicate that B7H1 (show CD274 Proteins)/CD80 interaction augments Tcon cell proliferation, IL-2 (show IL2 Proteins) production, and expression of PD-1 (show PDCD1 Proteins), which leads to increased apoptosis
CD28 (show CD28 Proteins)-CD80 interactions control regulatory T cell motility and immunological synapse formation.
demonstrates that the simultaneous silencing of CD40 (show CD40 Proteins) and CD80 genes has synergistic effects in preventing allograft rejection, and may therefore have therapeutic potential in clinical transplantation
Northern analysis revealed CD80 and CD86 (show CD86 Proteins) mRNAs in luteal tissue, with greatest steady-state concentrations at midcycle
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy.
B-lymphocyte activation antigen B7
, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
, CTLA-4 counter-receptor B7.1
, T-lymphocyte activation antigen CD80
, activation B7-1 antigen
, costimulatory factor CD80
, costimulatory molecule variant IgV-CD80
, CD80 antigen
, Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1)
, B7 protein
, B7-1 protein
, T-cell co-stimulatory protein B7-1