Browse our anti-CD86 (CD86) Antibodies

Mouse (Murine) CD86 Molecule (CD86) interaction partners

1. CD80/CD86 signaling plays a significant role in the initial inflammatory response to S. aureus.

2. Our results reveal a role for B7-2 as obligatory receptor for superantigens. B7-2 homodimer interface mimotopes prevent superantigen lethality by blocking the superantigen-host costimulatory receptor interaction.

3. results suggest that the TLR2-p38-CD86 signaling pathway plays a vital role in inflammation associated with burn injury

4. role with CD40 in primary germinal center generation of distinct antigen-presenting cells

5. The expression of CD1d showed a significantly negative correlation with CD86 level in B cells from imiquimod (IMQ)-treated mice, B6.MRLlpr mice, and lupus erythematosus (SLE) patients.

6. B7.2 expressed on skin CD8(+) T cells supports the survival of Tregs, likely through interaction with its receptor CTLA-4, which is highly expressed on skin Tregs.

7. CTLA-4(+) microvesicles can competitively bind B7 costimulatory molecules on bystander dendritic cells, resulting in downregulation of B7 surface expression.

8. Low CD86 expression is associated with B16 melanoma.

9. Local administration of CD86 siRNA during the effector phase ameliorates asthma phenotypes.

10. Meningococcal capsular polysaccharide-loaded vaccine nanoparticles induce expression of CD86.

11. The genetic inactivation of B7.1/B7.2 deteriorates obesity-related liver steatosis and metabolic dysregulation, likely a result of the intrinsic absence of Tregs in these mice, rendering DKO mice a novel murine model of NASH.

12. data show an important role of the adaptive immune system, in particular T cell CD80/86 costimulation molecules, in the physiological regulation of bone resorption and preservation of bone mass

13. CD80 and CD86 costimulatory molecules regulate OT-II CD4(+) T lymphocyte proliferation and cytokine response in cocultures with antigen-presenting cells derived from pregnant and pseudopregnant mice

14. novel function of CTLA4Ig in tumor immunity and suggest that CD86 on NK cells is an activating receptor and closely involved in the CTLA4Ig-mediated anti-tumor response.

15. The need for additional immune suppression in the intestine reflects commensal microbe-driven T-cell activation through the accessory costimulation molecules ICOSL and OX40L in B7 deprived mice.

16. CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1epsilon transgenic mice.

17. CD86 expression has functional consequences for the magnitude of CD4 T cell responses both in vitro and in vivo. These data pinpoint CD86 upregulation as an additional mechanism by which IL-21 can elicit immunomodulatory effects.

18. B7.1 and B7.2 molecules have equal ability to mediate host resistance to Mycobacterium tuberculosis.

19. The activation of protective CD8 T cells requires positive B7-1/B7-2 costimulation even when suppression by Tregs and in particular, Treg-intrinsic CTLA-4 is circumvented.

20. the results presented here demonstrate that recruitment and expression of MHC-II, CD80, CD86, PDL1, and PD-L2 in M of peritoneal cavity in T. crassiceps early at infection is associated to the sex of the host.

Human CD86 Molecule (CD86) interaction partners

1. CD86 may be involved in immunoregulation by its association with CTLA-4 in asymptomatic patients.

2. Our results suggest that the use of CD86 molecule as a proliferation marker for chronic lymphocytic leukemia is highly questionable. However, the CD86 molecule may interfere with the immune system of patients with chronic lymphocytic leukemia by activating and depleting immune functions

3. CD73 and CD86 are the most relevant markers to incorporate in the routine MRD evaluation of BCPALL.

4. DCreg resisted phenotypic and functional maturation and further upregulated PD-L1:CD86 expression.

5. CD86 gene rs1129055 and rs1915087 polymorphisms are significantly related to the risk of sepsis. For the rs1129055 polymorphism, the GA genotype and A allele are obviously correlated with increased risk of sepsis. Meanwhile, the carriers of the TT genotype and T allele of the rs1915087 polymorphism are more likely to develop sepsis.

6. Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2.

7. this study shows that recipients' CD86 gene polymorphisms influence the overall survival after allogeneic hematopoietic stem cell transplantation and, together with CTLA-4 polymorphisms, might be considered a risk factor for acute graft versus host disease

8. results strongly suggest that CD40 and CD86 play a role in the pathophysiology of oral inflammatory diseases such as OLP

9. Our results reveal a role for B7-2 as obligatory receptor for superantigens. B7-2 homodimer interface mimotopes prevent superantigen lethality by blocking the superantigen-host costimulatory receptor interaction.

10. Our study reports a novel association of SNPs within CD86 and CTLA4 genes with pemphigus. The CD86 rs1129055 A allele appears to confer susceptibility to Pemphigus vulgaris but not to pemphigus foliaceus.

11. Our data demonstrate that CML patients with high CD86(+)pDC counts have a higher risk of relapse after TKI discontinuation.

12. The expression of CD1d showed a significantly negative correlation with CD86 level in B cells from imiquimod (IMQ)-treated mice, B6.MRLlpr mice, and lupus erythematosus (SLE) patients.

13. IL-6, DEC205, and CD86 can be predictive biomarkers for the respiratory and immune effects of ambient PM2.5.

14. the upregulation of CD86 but not CD80 and PD-L1 on CD68+ cells in the liver of HBV-infected patients, observed in our study, suggest that the profile of CD68+ cells does not support the induction of proper Th1 responses that are needed to clear HBV infection. This might provide an explanation for the absence of potent HBV-specific T cells during chronic HBV infection.

15. CD86 variants association with susceptibility to multiple sclerosis in Iranian population.

16. B-cells from patients tolerant to the graft maintained higher IL-10 production after CD40 ligation, which correlates with lower CD86 expression compared to patients with chronic rejection.

17. TLR2, TLR4 and CD86 gene polymorphisms are associated with Recurrent aphthous stomatitis.

18. The SNP CD40 -1C>T was associated with the IgG response against PvDBP, whereas IgG antibody titers against PvMSP-119 were influenced by the polymorphism CD86 +1057G>A.

19. PD-L1 expression and the PD-L1/CD86 ratio in CD14(++)CD16(+) monocytes were higher during chronic hepatitis C virus infection.

20. Data show that induction of CD86 antigen expression on monocytes by human beta Defensin-3 (hBD-3) is suppressed by P2X7 purinoceptor (P2X7R) antagonist.

Pig (Porcine) CD86 Molecule (CD86) interaction partners

1. Reduced CD86 antigen is associated with melanoma.

2. The complete cDNA encoding CD86 molecule of miniature swine was cloned, sequenced and analyzed.

Cow (Bovine) CD86 Molecule (CD86) interaction partners

1. Northern analysis revealed CD80 and CD86 mRNAs in luteal tissue, with greatest steady-state concentrations at midcycle