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Our results reveal a role for B7-2 as obligatory receptor for superantigens. B7-2 homodimer interface mimotopes prevent superantigen lethality by blocking the superantigen-host costimulatory receptor interaction.
results suggest that the TLR2-p38 (show CRK Proteins)-CD86 signaling pathway plays a vital role in inflammation associated with burn injury
role with CD40 (show CD40 Proteins) in primary germinal center generation of distinct antigen-presenting cells
The expression of CD1d (show CD1D Proteins) showed a significantly negative correlation with CD86 level in B cells from imiquimod (IMQ)-treated mice, B6.MRLlpr mice, and lupus erythematosus (SLE) patients.
B7.2 expressed on skin CD8 (show CD8A Proteins)(+) T cells supports the survival of Tregs, likely through interaction with its receptor CTLA-4 (show CTLA4 Proteins), which is highly expressed on skin Tregs.
CTLA-4 (show CTLA4 Proteins)(+) microvesicles can competitively bind B7 costimulatory molecules on bystander dendritic cells, resulting in downregulation of B7 surface expression.
Low CD86 expression is associated with B16 melanoma.
Local administration of CD86 siRNA during the effector phase ameliorates asthma phenotypes.
Meningococcal capsular polysaccharide-loaded vaccine nanoparticles induce expression of CD86.
The genetic inactivation of B7.1/B7.2 deteriorates obesity-related liver steatosis and metabolic dysregulation, likely a result of the intrinsic absence of Tregs in these mice, rendering DKO mice a novel murine model of NASH (show SAMSN1 Proteins).
this study shows that recipients' CD86 gene polymorphisms influence the overall survival after allogeneic hematopoietic stem cell transplantation and, together with CTLA-4 (show CTLA4 Proteins) polymorphisms, might be considered a risk factor for acute graft versus host disease
results strongly suggest that CD40 (show CD40 Proteins) and CD86 play a role in the pathophysiology of oral inflammatory diseases such as OLP
Our study reports a novel association of SNPs within CD86 and CTLA4 (show CTLA4 Proteins) genes with pemphigus. The CD86 rs1129055 A allele appears to confer susceptibility to Pemphigus vulgaris (show DSG3 Proteins) but not to pemphigus foliaceus (show DSG1 Proteins).
Our data demonstrate that CML (show BCR Proteins) patients with high CD86(+)pDC (show PNKD Proteins) counts have a higher risk of relapse after TKI discontinuation.
IL-6 (show IL6 Proteins), DEC205 (show LY75 Proteins), and CD86 can be predictive biomarkers for the respiratory and immune effects of ambient PM2.5.
the upregulation of CD86 but not CD80 (show CD80 Proteins) and PD-L1 (show CD274 Proteins) on CD68 (show CD68 Proteins)+ cells in the liver of HBV-infected patients, observed in our study, suggest that the profile of CD68 (show CD68 Proteins)+ cells does not support the induction of proper Th1 (show TH1L Proteins) responses that are needed to clear HBV infection. This might provide an explanation for the absence of potent HBV-specific T cells during chronic HBV infection.
CD86 variants association with susceptibility to multiple sclerosis in Iranian population.
B-cells from patients tolerant to the graft maintained higher IL-10 (show IL10 Proteins) production after CD40 (show CD40 Proteins) ligation, which correlates with lower CD86 expression compared to patients with chronic rejection.
Reduced CD86 antigen is associated with melanoma.
The complete cDNA encoding CD86 molecule of miniature swine was cloned, sequenced and analyzed.
Northern analysis revealed CD80 (show CD80 Proteins) and CD86 mRNAs in luteal tissue, with greatest steady-state concentrations at midcycle
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
, T-lymphocyte activation antigen CD86
, activation B7-2 antigen
, early T cell costimulatory molecule-1
, early T-cell costimulatory molecule 1
, B-lymphocyte activation antigen B7-2
, CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
, CTLA-4 counter-receptor B7.2
, cd86 antigen
, membrane glycoprotein
, B7-2 protein
, co-stimulatory molecule B7-2
, costimulatory molecule
, CD86/B7-2 costimulatory molecule
, B7-1 costimulatory molecule