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Lck (show LCK ELISA Kits)-CD8 (show CD8A ELISA Kits) interaction is required for initial CD8 (show CD8A ELISA Kits) recruitment.
Comparing the sequences of mouse, human, rat and dog Cd8a and Cd8b1 gene loci identified 10 evolutionarily conserved regions (ECR). 6 ECRs overlapped with previously identified Cd8 enhancers. ECR-4 recruits transcription factors to the Cd8ab gene complex.
CREMalpha orchestrates epigenetic remodeling of the CD8A (show CD8A ELISA Kits),B through the recruitment of DNA methyltransferase (show DNMT1 ELISA Kits) (DNMT (show DNMT1 ELISA Kits)) 3a and histone methyltransferase G9a (show EHMT2 ELISA Kits).
We propose that ADP-ribosylation of CD8 (show CD8A ELISA Kits)-beta can regulate the coreceptor function of CD8 (show CD8A ELISA Kits) in the presence of elevated levels of extracellular NAD(+) .
sialylation in a discrete segment of the CD8beta stalk by ST3Gal-1 sialyltransferase creates a molecular developmental switch that affects ligand binding
Data demonstrate that major histocompatibility complex-I-signaled thymocytes appear as CD4 (show CD4 ELISA Kits)+8lo cells because of transient down-regulation of CD8 (show CD8A ELISA Kits) gene expression, not because of changes in CD8 (show CD8A ELISA Kits) surface protein expression or distribution.
The stalk region of CD8 (show CD8A ELISA Kits) beta is capable of fine-tuning the coreceptor function of CD8 (show CD8A ELISA Kits) proteins as a coreceptor, possibly due to its distinct protein structure, smaller physical size and the unique glycan adducts associated with this region.
results demonstrate epigenetic control of the Cd8 (show CD8A ELISA Kits) loci and identify MAZR as an important regulator of Cd8 (show CD8A ELISA Kits) expression
The crystal structure of the CD8alphabeta immunoglobulin-like ectodomains were determined in complex with mAb YTS156.7 Fab (show FANCB ELISA Kits) at 2.7 A resolution, was elucidated.
The stalk region of CD8beta influences the ability of CD8 (show CD8A ELISA Kits) to bind class I major histocompatibility complexes and is therefore critical for the correct functioning of CD8alphabeta heterodimers.
results suggest that mycoplasma induces a resistance to multiple drugs in hepatocarcinoma cells which required the interaction of P37 (show CCNH ELISA Kits) and Annexin A2 (show ANXA2 ELISA Kits). The pathway downstream this interaction needs to be explored
Endometrioid endometrial carcinomas are capable of down-regulating CD8 (show CD8A ELISA Kits) expression by cytotoxic T lymphocytes.
transcription factor cAMP-responsive element modulator (show CREM ELISA Kits) alpha (CREMalpha), which is expressed at increased levels in T cells from systemic lupus erythematosus patients, contributes to transcriptional silencing of CD8A (show CD8A ELISA Kits) and CD8B.
A clustering of DNase (show DNASE2 ELISA Kits) hypersensitivity sites and matrix attachment regions capable of binding SATB1 (show SATB1 ELISA Kits) and GATA-3 (show GATA3 ELISA Kits), colocalized at the 3' end of the CD8B gene, suggests that this region is an epigenetic regulator of CD8 (show CD8A ELISA Kits) expression.
RT-PCR, and related methodologies are not useful substitutes for assessment of CD4 (show CD4 ELISA Kits) and CD8 (show CD8A ELISA Kits) cell numbers in HIV-infected persons.
study demonstrated differential mRNA expression patterns of CD8beta splice variants in thymocytes and in resting, memory, and activated primary CD8 (show CD8A ELISA Kits)(+) T cells
Data show that CD8 (show CD8A ELISA Kits)+LAP+ cells produce IFN-gamma (show IFNG ELISA Kits), and these cells suppress EAE that is dependent on both TGF-beta (show TGFB1 ELISA Kits) and IFN-gamma (show IFNG ELISA Kits).
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.
, CD8 beta-2
, T-cell surface glycoprotein CD8 beta chain
, CD8 antigen beta polypeptide
, T-cell membrane glycoprotein Ly-3
, T-cell surface glycoprotein Lyt-3
, lymphocyte antigen 3
, CD8 antigen, beta polypeptide 1 (p37)
, T lymphocyte surface glycoprotein beta chain
, CD8 antigen 37 kDa chain
, CD8 antigen beta-chain
, CD8 antigen, beta chain
, CD8 antigen, beta-chain
, OX-8 membrane antigen
, CD8 beta chain
, CD8 antigen, beta polypeptide
, CD8b antigen