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anti-Human Cytoplasmic Protein NCK1 Antibodies:
anti-Rat (Rattus) Cytoplasmic Protein NCK1 Antibodies:
anti-Mouse (Murine) Cytoplasmic Protein NCK1 Antibodies:
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Human Monoclonal Cytoplasmic Protein NCK1 Primary Antibody for FACS, IHC - ABIN969545
Preisinger, Kolch: The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway. in Cellular signalling 2010
Show all 2 Pubmed References
There was no difference in the Nck1 mRNA expression between the SLE patients and the healthy subjects.
this study highlights an important role for Nck1 in fine-tuning IRE1alpha (show ERN1 Antibodies) expression and signaling that regulate PTP1B (show PTPN1 Antibodies) expression and subsequent activation of the PI3K (show PIK3CA Antibodies)-Akt (show AKT1 Antibodies) pathway in HepG2 cells.
These findings suggest a novel STAT3 (show STAT3 Antibodies) to NCK1 to PAK1 (show PAK1 Antibodies)/ERK (show EPHB2 Antibodies) signaling mechanism that is potentially critical for colorectal cancer metastasis and angiogenesis.
Authors provide evidence that Nck is an upstream regulator of RhoA (show RHOA Antibodies)-dependent, MMP14 (show MMP14 Antibodies)-mediated breast carcinoma cell invasion.
Nck1 and Nck2 (show NCK2 Antibodies) Interact with WTIP (show WTIP Antibodies). Nck1/2 integrates nephrin (show NPHS1 Antibodies) with the Hippo kinase cascade through association with the adaptor protein WTIP (show WTIP Antibodies).
Results demonstrate that Nck acts as an important hub integrating angiogenic cues with cytoskeletal changes that enable endothelial apical-basal polarization and lumen formation.
the binding of Nck to the TCR requires partial phosphorylation of CD3epsilon (show CD3E Antibodies), as it is based on two cooperating interactions.
Nck was the most potent activator of N-WASP-driven actin assembly.
TSAD (show SH2D2A Antibodies) binds to and co-localizes with Nck. Expression of TSAD (show SH2D2A Antibodies) increases both Nck-Lck (show LCK Antibodies) and Nck-SLP-76 (show LCP2 Antibodies) interaction in T cells.
these data identify Nck as an important mediator of oxidative stress-induced (show SQSTM1 Antibodies) inflammation and a potential therapeutic target for ischemia/reperfusion injury.
Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses.
In mice with Nck1/2 deletions, endothelial cells fail to develop front-rear polarized vessel sprouts.
These results reveal that Nck regulates preosteoblastic/osteoblastic migration and bone mass.
we show that the non-catalytic region of tyrosine kinase adaptor (NCK) proteins 1 and 2 are distributed in the developing spinal cord
Nck proteins not only participate in thymic selection and generation of the peripheral T cell repertoire but also are involved in the differentiation and effector functions of CD4 (show CD4 Antibodies)(+) T cells.
Nck may function as an effector of T-cell receptor conformational changes during T cell development.
Mouse embryos lacking endothelial Nck1/2 expression develop extensive angiogenic defects that result in lethality at about embryonic day 10.
Nck1 negatively regulates PERK (show EIF2AK3 Antibodies) by interacting with PERK (show EIF2AK3 Antibodies) and protecting PERK (show EIF2AK3 Antibodies) from being dephosphorylated at its inhibitory site pY(561) and in this way affects pancreatic beta-cell proinsulin (show INS Antibodies) biogenesis.
that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3epsilon (show CD3E Antibodies) interaction may represent a target for pharmacological modulation of the immune response.
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
NCK tyrosine kinase
, SH2/SH3 adaptor protein NCK-alpha
, cytoplasmic protein NCK1
, melanoma NCK protein
, non-catalytic region of tyrosine kinase
, non-catalytic region of tyrosine kinase adaptor protein 1
, NCK adaptor protein 1
, cytoplasmic protein NCK1-like
, NCK adaptor protein 1 L homeolog
, SH2/SH3 adaptor protein