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Human Cytoplasmic Protein NCK1 Protein expressed in Mouse - ABIN1774727
Borroto, Arellano, Dopfer, Prouza, Suchànek, Fuentes, Orfao, Schamel, Alarcón: Nck recruitment to the TCR required for ZAP70 activation during thymic development. in Journal of immunology (Baltimore, Md. : 1950) 2013
this study highlights an important role for Nck1 in fine-tuning IRE1alpha (show ERN1 Proteins) expression and signaling that regulate PTP1B (show PTPN1 Proteins) expression and subsequent activation of the PI3K (show PIK3CA Proteins)-Akt (show AKT1 Proteins) pathway in HepG2 cells.
These findings suggest a novel STAT3 (show STAT3 Proteins) to NCK1 to PAK1 (show PAK1 Proteins)/ERK (show EPHB2 Proteins) signaling mechanism that is potentially critical for colorectal cancer metastasis and angiogenesis.
Authors provide evidence that Nck is an upstream regulator of RhoA (show RHOA Proteins)-dependent, MMP14 (show MMP14 Proteins)-mediated breast carcinoma cell invasion.
Nck1 and Nck2 (show NCK2 Proteins) Interact with WTIP (show WTIP Proteins). Nck1/2 integrates nephrin (show NPHS1 Proteins) with the Hippo kinase cascade through association with the adaptor protein WTIP (show WTIP Proteins).
Results demonstrate that Nck acts as an important hub integrating angiogenic cues with cytoskeletal changes that enable endothelial apical-basal polarization and lumen formation.
the binding of Nck to the TCR requires partial phosphorylation of CD3epsilon (show CD3E Proteins), as it is based on two cooperating interactions.
Nck was the most potent activator of N-WASP-driven actin assembly.
TSAD (show SH2D2A Proteins) binds to and co-localizes with Nck. Expression of TSAD (show SH2D2A Proteins) increases both Nck-Lck (show LCK Proteins) and Nck-SLP-76 (show LCP2 Proteins) interaction in T cells.
these data identify Nck as an important mediator of oxidative stress-induced (show SQSTM1 Proteins) inflammation and a potential therapeutic target for ischemia/reperfusion injury.
Nck1 depletion induces activation of the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway by attenuating PTP1B (show PTPN1 Proteins) protein expression
Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses.
In mice with Nck1/2 deletions, endothelial cells fail to develop front-rear polarized vessel sprouts.
These results reveal that Nck regulates preosteoblastic/osteoblastic migration and bone mass.
we show that the non-catalytic region of tyrosine kinase adaptor (NCK) proteins 1 and 2 are distributed in the developing spinal cord
Nck proteins not only participate in thymic selection and generation of the peripheral T cell repertoire but also are involved in the differentiation and effector functions of CD4 (show CD4 Proteins)(+) T cells.
Nck may function as an effector of T-cell receptor conformational changes during T cell development.
Mouse embryos lacking endothelial Nck1/2 expression develop extensive angiogenic defects that result in lethality at about embryonic day 10.
Nck1 negatively regulates PERK (show EIF2AK3 Proteins) by interacting with PERK (show EIF2AK3 Proteins) and protecting PERK (show EIF2AK3 Proteins) from being dephosphorylated at its inhibitory site pY(561) and in this way affects pancreatic beta-cell proinsulin (show INS Proteins) biogenesis.
that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3epsilon (show CD3E Proteins) interaction may represent a target for pharmacological modulation of the immune response.
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
NCK tyrosine kinase
, SH2/SH3 adaptor protein NCK-alpha
, cytoplasmic protein NCK1
, melanoma NCK protein
, non-catalytic region of tyrosine kinase
, non-catalytic region of tyrosine kinase adaptor protein 1
, NCK adaptor protein 1
, cytoplasmic protein NCK1-like
, NCK adaptor protein 1 L homeolog
, SH2/SH3 adaptor protein