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results of this study indicate that a novel T cell adaptor protein, activation-dependent, raft-recruited ADAP-like phosphoprotein (ARAP (show MDK Proteins)), plays a unique role in T cells as a part of both the proximal activation signaling and inside-out signaling pathways that result in integrin activation and T cell adhesion
Ubc9 is an essential regulator of ADAP where it is required for TCR-induced membrane recruitment of the small GTPase Rap1 and its effector protein RapL and for activation of the small GTPase Rac1 in T cell adhesion.
Current knowledge of the functions of the adapter protein ADAP in T cell signaling with a focus on the role of individual phosphotyrosine (pY) motifs for SH2 domain mediated interactions is presented.
A distinct set of proteins interaction partners required for chemokine (show CCL1 Proteins)-directed T cell migration is attracted by phosphotyrosine 571 of ADAP, including ZAP70 (show ZAP70 Proteins).
Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.
FYB nonsense mutations in humans causing small-platelet thrombocytopenia and a significant bleeding tendency.
Data (including data from studies in knockout/transgenic mice) suggest that ADAP regulates positive feedback loop of TGFbeta1 (show TGFB1 Proteins) production and TGFbeta1 (show TGFB1 Proteins)-induced CD103 (show ITGAE Proteins) expression in CD8 (show CD8A Proteins)+ T-lymphocytes and protects against influenza H5N1 virus infection.
The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset.
The autosomal recessive bleeding phenotype seen in several members of this highly consanguineous family included petechial rash, mild epistaxis and thrombocytopenia with some decrease in platelet volume. These clinical findings, together with the results of exome sequencing pointed to only one strong candidate gene, the FYB gene.
ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.
ADAP (show APP Proteins) fulfills different functions in CD4 (show CD4 Proteins)(+) and CD8 (show CD8A Proteins)(+) T cells, with CD8 (show CD8A Proteins)(+) T cells being less dependent on ADAP (show APP Proteins).
ADAP (show APP Proteins) regulates CD8 (show CD8A Proteins) T cell differentiation events following acute pathogen challenge that are critical for the formation and selected functions of TRM cells in nonlymphoid tissues.
Data (including data from studies in knockout/transgenic mice) suggest that ADAP (show APP Proteins) regulates positive feedback loop of TGFbeta1 (show TGFB1 Proteins) production and TGFbeta1 (show TGFB1 Proteins)-induced CD103 (show ITGAE Proteins) expression in CD8 (show CD8A Proteins)+ T-lymphocytes and protects against influenza H5N1 virus infection.
The results indicate that ADAP (show APP Proteins) dampens naive CD8 (show CD8A Proteins) T cell responses to lymphopenia and IL-15 (show IL15 Proteins), and they demonstrate a novel Ag-independent function for ADAP (show APP Proteins) in the suppression of memory phenotype CD8 (show CD8A Proteins) T cell generation.
provide evidence that CD28 (show CD28 Proteins) and the TCR complex regulate NF-kappaB (show NFKB1 Proteins) via different signaling modules of GRB-2 (show GRB2 Proteins)/VAV1 (show VAV1 Proteins) and LAT (show LAT Proteins)/ADAP (show APP Proteins) pathways respectively.
we demonstrate that loss of ADAP (show APP Proteins) promotes resistance of experimental autoimmune encephalomyelitis in mice, likely by trapping encephalitogenic T cells in the peripheral lymph nodes on LYVE-1 (show LYVE1 Proteins)+ lymphatic structures.
Signaling by Fyn (show FYN Proteins)-ADAP (show APP Proteins) via the Carma1 (show CARD11 Proteins)-Bcl-10 (show BCL10 Proteins)-MAP3K7 (show MAP3K7 Proteins) signalosome exclusively regulates inflammatory cytokine production in NK cells.
integrin activation by the ADAP (show APP Proteins)-SKAP55 (show SKAP1 Proteins)-signaling module controls the stability and duration of T cell-dendritic cell contacts during the progressive phases necessary for optimal T cell activation.
ADAP (show APP Proteins) coordinates distinct CARMA1 (show CARD11 Proteins)-dependent control of key cell cycle proteins in T cells
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene.
, FYN-T-binding protein
, SLP-76-associated phosphoprotein
, adhesion and degranulation-promoting adaptor protein
, FYN binding protein FYB-130
, adhesion and degranulation promoting adaptor protein
, FYN binding protein (FYB-120/130)