Protein Summary

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.

Alternative names and synonyms associated with HLA Class II DR alpha (HLA-DRA)

• major histocompatibility complex, class II, DR alpha L homeolog (hla-dra.L) antibody
• major histocompatibility complex, class II, DR alpha (HLA-DRA) antibody
• major histocompatibility complex, class II, DR alpha (MAMU-DRA) antibody
• major histocompatibility complex, class II, DR alpha (BOLA-DRA) antibody

• DR-alpha antibody
• HLA-DRA antibody
• HLA-DRA1 antibody
• Mamu-DRA1 antibody
• MLRW antibody

Protein level used designations for HLA-DRA

major histocompatibility complex, class II, DR alpha , HLA class II histocompatibility antigen, DR alpha chain , MHC cell surface glycoprotein , MHC class II antigen DRA , histocompatibility antigen HLA-DR alpha , MHC class II DRA , MHC class II antigen , BoLA-DR-alpha