Browse our anti-RAP1A (RAP1A) Antibodies

Human RAP1A, Member of RAS Oncogene Family (RAP1A) interaction partners

1. these data highlight a signaling pathway in which SHP-1 acts through CrkII to reshape the pattern of Rap1 activation in the immunological synapse.

2. Study identifies Epac2-Rap1 signaling as a novel feedback mechanism in the heart, which controls mitochondrial reactive oxygen species production.

3. Data show that the Epac-Rap1 signaling axis is involved in triapine resistance.

4. Ubc9 (show UBE2I Antibodies) is an essential regulator of ADAP (show FYB Antibodies) where it is required for TCR-induced membrane recruitment of the small GTPase (show RACGAP1 Antibodies) Rap1 (show RABGEF1 Antibodies) and its effector protein RapL (show RASSF5 Antibodies).

5. These findings provide the first evidence linking Rap1A with ovarian cancer development through the ERK/p38 (show MAPK1 Antibodies) and Notch (show NOTCH1 Antibodies) signaling pathways, indicating that Rap1A may be used as a novel diagnostic marker or a therapeutic target for ovarian cancer.

6. High RAP1 (show RABGEF1 Antibodies) expression is associated with neuroblastoma (show ARHGEF16 Antibodies).

7. Rap1 mediates the effects of increased extracellular tension in multiple ways that are capable of contributing to tumor progression when dysregulated.

8. Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction

9. Unlike Rap1B (show RAP1B Antibodies), phosphorylation in the polybasic region of Rap1A does not detectably inhibit its prenylation or its binding to SmgGDS (show RAP1GDS1 Antibodies)-607.

10. SHANK1 (show SHANK1 Antibodies) and SHANK3 (show SHANK3 Antibodies) act as integrin activation inhibitors by sequestering active Rap1 (show RABGEF1 Antibodies) and R-Ras via the SPN (show SPN Antibodies) domain and thus limiting their bioavailability at the plasma membrane.

Mouse (Murine) RAP1A, Member of RAS Oncogene Family (RAP1A) interaction partners

1. Using an RNA-mediated interference screen, we identified phospholipase Cepsilon 1 (PLCepsilon1) as a crucial regulator of stromal cell-derived factor 1 alpha (SDF-1alpha)-induced Rap1 activation. We have shown that SDF-1alpha-induced activation of Rap1 is transient in comparison with the sustained level following cross-linking of the antigen receptor.

2. loss of Rap1 GTPases prevents the formation of axons and leading processes and thereby interferes with radial migration

3. neuronal Rap1 (show TERF2IP Antibodies) critically regulates leptin (show LEP Antibodies) sensitivity

4. the Rap1-cofilin-1 pathway coordinates actin and microtubule organization at the immune synapse.

5. Rap1 mediates the effects of increased extracellular tension in multiple ways that are capable of contributing to tumor progression when dysregulated.

6. Results from comparative proteomics identified Rap1 as a novel legionella-containing-vacuole host component implicated in intracellular replication of Legionella pneumophila.

7. These results suggest that Rap1 (show TERF2IP Antibodies) activation of ERKs requires PKA phosphorylation and KSR (show KSR1 Antibodies) binding.

8. the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure

9. These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.

10. Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature

Zebrafish RAP1A, Member of RAS Oncogene Family (RAP1A) interaction partners

1. RAP1 (show TERF2IP Antibodies)-mediated MEK (show MAP2K1 Antibodies)/ERK (show MAPK1 Antibodies) pathway defects in Kabuki syndrome.

Cow (Bovine) RAP1A, Member of RAS Oncogene Family (RAP1A) interaction partners

1. Rap1 (show TERF2IP Antibodies) increases KRIT-1 (show KRIT1 Antibodies) targeting to endothelial cell-cell junctions where it suppresses stress fibers and stabilizes junctional integrity.