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Human Monoclonal RAP1A Primary Antibody for FACS, ELISA - ABIN969561
Severson, Lee, Capaldo, Nusrat, Parkos: Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration. in Molecular biology of the cell 2009
Show all 2 Pubmed References
Human Monoclonal RAP1A Primary Antibody for FACS, ELISA - ABIN969562
Dao, Dupuy, Gavet, Caron, de Gunzburg: Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis. in Journal of cell science 2009
Show all 2 Pubmed References
Human Monoclonal RAP1A Primary Antibody for PLA, ELISA - ABIN519632
Chen, Chuang, Huang, Fang, Huang, Tsai, Su, Shiu, Leu, Chien: Overexpression of Rap-1A indicates a poor prognosis for oral cavity squamous cell carcinoma and promotes tumor cell invasion via Aurora-A modulation. in The American journal of pathology 2013
these data highlight a signaling pathway in which SHP-1 acts through CrkII to reshape the pattern of Rap1 activation in the immunological synapse.
Study identifies Epac2-Rap1 signaling as a novel feedback mechanism in the heart, which controls mitochondrial reactive oxygen species production.
Data show that the Epac-Rap1 signaling axis is involved in triapine resistance.
Ubc9 (show UBE2I Antibodies) is an essential regulator of ADAP (show FYB Antibodies) where it is required for TCR-induced membrane recruitment of the small GTPase (show RACGAP1 Antibodies) Rap1 (show RABGEF1 Antibodies) and its effector protein RapL (show RASSF5 Antibodies).
These findings provide the first evidence linking Rap1A with ovarian cancer development through the ERK/p38 (show MAPK1 Antibodies) and Notch (show NOTCH1 Antibodies) signaling pathways, indicating that Rap1A may be used as a novel diagnostic marker or a therapeutic target for ovarian cancer.
High RAP1 (show RABGEF1 Antibodies) expression is associated with neuroblastoma (show ARHGEF16 Antibodies).
Rap1 mediates the effects of increased extracellular tension in multiple ways that are capable of contributing to tumor progression when dysregulated.
Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction
Unlike Rap1B (show RAP1B Antibodies), phosphorylation in the polybasic region of Rap1A does not detectably inhibit its prenylation or its binding to SmgGDS (show RAP1GDS1 Antibodies)-607.
SHANK1 (show SHANK1 Antibodies) and SHANK3 (show SHANK3 Antibodies) act as integrin activation inhibitors by sequestering active Rap1 (show RABGEF1 Antibodies) and R-Ras via the SPN (show SPN Antibodies) domain and thus limiting their bioavailability at the plasma membrane.
Using an RNA-mediated interference screen, we identified phospholipase Cepsilon 1 (PLCepsilon1) as a crucial regulator of stromal cell-derived factor 1 alpha (SDF-1alpha)-induced Rap1 activation. We have shown that SDF-1alpha-induced activation of Rap1 is transient in comparison with the sustained level following cross-linking of the antigen receptor.
loss of Rap1 GTPases prevents the formation of axons and leading processes and thereby interferes with radial migration
neuronal Rap1 (show TERF2IP Antibodies) critically regulates leptin (show LEP Antibodies) sensitivity
the Rap1-cofilin-1 pathway coordinates actin and microtubule organization at the immune synapse.
Results from comparative proteomics identified Rap1 as a novel legionella-containing-vacuole host component implicated in intracellular replication of Legionella pneumophila.
These results suggest that Rap1 (show TERF2IP Antibodies) activation of ERKs requires PKA phosphorylation and KSR (show KSR1 Antibodies) binding.
the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure
These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.
Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature
RAP1 (show TERF2IP Antibodies)-mediated MEK (show MAP2K1 Antibodies)/ERK (show MAPK1 Antibodies) pathway defects in Kabuki syndrome.
Rap1 (show TERF2IP Antibodies) increases KRIT-1 (show KRIT1 Antibodies) targeting to endothelial cell-cell junctions where it suppresses stress fibers and stabilizes junctional integrity.
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
, GTP-binding protein smg p21A
, RAS-related protein RAP1A
, Ras-related protein Krev-1
, ras-related protein Rap-1A
, RAP1A, member of RAS oncogene family
, GTP-binding protein SMG-P21A
, ras-related protein Krev-1
, RAS-related protein 1a
, GTP-binding protein smg-p21A