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guanine nucleotide exchange factor (show ARHGEF12 Proteins) RasGRP1 inhibited Rhes (show RASD2 Proteins)-mediated control of striatal motor activity in mice. RasGRP1 stabilized Rhes (show RASD2 Proteins), increasing its synaptic accumulation in the striatum.
signaling underpins thymic selection processes induced by both weak and strong TCR signals and is differentially required for fate decisions derived from a strong TCR stimulus
RasGRP1/3-deficient progenitors show impaired migration toward the CCR9 (show CCR9 Proteins) ligand, CCL25 (show CCL25 Proteins), suggesting that RasGRP1 and RasGRP3 (show RASGRP3 Proteins) may regulate progenitor entry into the thymus through a CCR9 (show CCR9 Proteins)-dependent mechanism.
RasGRP1 is indispensable for development of B1a cells with autoantigen receptors, revealing a connection between a signaling molecule and development of a specific repertoire within the B1a cell population
Genetic Rasgrp1 depletion from mice with either an activating mutation in KRas or with aberrant Wnt (show WNT2 Proteins) signalling due to a mutation in Apc (show APC Proteins) resulted in both cases in exacerbated Ras-ERK (show EPHB2 Proteins) signalling and cell proliferation.
CD44 (show CD44 Proteins) expression, CD4 (show CD4 Proteins)(+) T cell subset ratios and serum autoantibodies all returned to normal in Rasgrp1(Anaef)Mtor (show FRAP1 Proteins)(chino) double-mutant mice
RasGRP1 upregulates signaling from Ras and contributes to epidermal tumorigenesis by increasing the total dosage of active Ras.
autoreactive B cells lacking Rasgrp1 break central and peripheral tolerance through both T cell-independent and -dependent mechanisms.
Dysregulated RasGRP1 responds to cytokine receptor (show LEPR Proteins) input in T cell leukemogenesis.
RasGRP1, but not RasGRP3 (show RASGRP3 Proteins), is required for thymocyte positive selection and invariant natural killer T cell selection.
The marked differences between RasGRP3 (show RASGRP3 Proteins) and RasGRP1 in membrane interaction necessarily will contribute to their different behavior in cells.
Cytokines IL-2 (show IL2 Proteins)/7/9 stimulation activates PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathways downstream of Ras in RasGRP1 T-cell acute lymphoblastic leukemia (T-ALL).
results demonstrate the critical role of CalDAG-GEFI in rapid alphaIIbbeta3 activation of human platelets.
This study shows that deficiency in RASGRP1 results in a previously unknown primary immunodeficiency disease, and that RASGRP1 plays role in immune cell signaling and function in T cells, B cells and NK cells. It also identifies a previously unknown role for RASGRP1 in the dynamic regulation of the cytoskeleton, and identify lenalidomide as a potpotential treatment option for this immunodeficiency.
This study aimed to replicate and verify the association of RASGRP1 tag single-nucleotide polymorphisms with T2D in a Chinese Han population.
present a crystal structure of a fragment of RasGRP1 in which the Ras-binding site is blocked by an interdomain linker and the membrane-interaction surface of RasGRP1 is hidden within a dimerization interface
A genome-wide association study identifies GRK5 (show GRK5 Proteins) and RASGRP1 as type 2 diabetes loci in Chinese Hans.
This is the first study aimed at evaluating CalDAG-GEFI gene sequences in people with mucocutaneous bleeding of unknown cause.
PAQR10 (show MMD2 Proteins) and PAQR11 (show MMD Proteins) are able to interact with RasGRP1, a guanine nucleotide exchange protein (show EEF1D Proteins) of Ras, and increase Golgi localization of RasGRP1. The C1 domain of RasGRP1 is both necessary and sufficient for the interaction of RasGRP1 with PAQR10 (show MMD2 Proteins)/PAQR11 (show MMD Proteins).
cooperation between aberrant expression of RasGRP1, a strong activator of Ras, and secondary gain-of-function mutations of NOTCH1 (show NOTCH1 Proteins) have an important role in T-cell leukemogenesis
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
RAS guanyl-releasing protein 1
, calcium and DAG-regulated guanine nucleotide exchange factor II
, RAS guanyl nucleotide-releasing protein 1
, guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A
, ras activator RasGRP