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This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
RAS guanyl-releasing protein 1
, calcium and DAG-regulated guanine nucleotide exchange factor II
, RAS guanyl nucleotide-releasing protein 1
, guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A
, ras activator RasGRP