Browse our RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) Proteins (RASGRP1)

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

• RAS guanyl releasing protein 1 (Rasgrp1)
• RAS guanyl releasing protein 1 (RASGRP1)

• CALDAG-GEFI protein
• CALDAG-GEFII protein
• hRasGRP1 protein
• RASGRP protein
• V protein

RAS guanyl-releasing protein 1 , calDAG-GEFII , calcium and DAG-regulated guanine nucleotide exchange factor II , RAS guanyl nucleotide-releasing protein 1 , guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A , ras activator RasGRP , CalDAG-GEF1