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RIP2-knockout attenuates cardiac injury and dysfunction in hypertrophic heart. RIP2-deficience alleviates inflammation in heart of hypertrophic mice. RIP2-deletion inhibits fibrosis in the heart of hypertrophic mice.
this study reveals that LRRK2 is a new positive regulator of Rip2 and promotes inflammatory cytokine induction through the Nod1/2-Rip2 pathway.
that Rip2 (show ARHGDIG Proteins) modifies VEGF (show VEGFA Proteins)-induced signalling and vascular permeability in myocardial ischaemia
Bacterial polysaccharide-responsive miR-150 and miR-143 RIPK2 and TAK1 to suppress NOD2-induced immunomodulators.
NOD2 downregulates colonic inflammation by IRF4 (show IRF4 Proteins)-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6 (show TRAF6 Proteins).
RIPK2 has a role in NOD signalling and in inflammatory cytokine production
Rip2 (show ARHGDIG Proteins)-deficient tumors showed enhanced epithelial-to-mesenchymal transition, with elevated expression of zeb1, zeb2, twist, and snail (show SNAI1 Proteins) in the tumor microenvironment.
data show that Nod1 (show NOD1 Proteins), Nod2 and Rip2 (show ARHGDIG Proteins) are not required for local chemokine (show CCL1 Proteins) production and neutrophil recruitment during CLP (show HAPLN1 Proteins)-induced sepsis, and they reinforce the importance of MyD88 (show MYD88 Proteins)-dependent signaling for initiation of a protective host response.
Suggest that the Nod2-Rip2 axis may contribute to the innate immune response of neutrophils against bacterial infection.
Nod/Ripk2 signaling in dendritic cells activates IL-17A (show IL17A Proteins)-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2 (show RAG2 Proteins)-/- (TRUC) mice.
Together, these data show that RIP2 promotes survival of breast cancer cells through NF-kappaB activation and that targeting RIP2 may be therapeutically beneficial for treatment of TNBC.
RIP2 kinase auto-phosphorylation is intimately coupled to dimerization.
study provides structural and dynamic insights into the NOD1 (show NOD1 Proteins)-RIP2 oligomer formation, which will be crucial in understanding the molecular basis of NOD1 (show NOD1 Proteins)-mediated CARD-CARD interaction in higher and lower eukaryotes
a new function of PAX5 in regulating RIP1 and RIP2 activation, which is at least involved in chemotherapeutic drug resistance in B-lymphoproliferative disorders, is reported.
Together, the data demonstrate that the NOD2-RIP2 pathway is activated in murine and human visceral leishmaniasis and plays a role in shaping adaptive immunity toward a Th1 (show TH1L Proteins) profile.
RIP2 and RhoGDI (show ARHGDIA Proteins) bind to p75(NTR (show NGFR Proteins)) death domain at partially overlapping epitopes with over 100-fold difference in affinity, revealing the mechanism by which RIP2 recruitment displaces RhoGDI (show ARHGDIA Proteins) upon ligand binding.
that Rip2 modifies VEGF (show VEGFA Proteins)-induced signalling and vascular permeability in myocardial ischaemia
Barettin has inhibitory activity against two protein kinases related to inflammation, namely the receptor-interacting serine/threonine kinase 2 (RIPK2) and calcium/calmodulin-dependent protein kinase 1alpha (CAMK1alpha).
RIPK1 (show RIPK1 Proteins) and RIPK2 are targets of HIV-1 Protease activity during infection, and their inactivation may contribute to modulation of cell death and host defense pathways by HIV-1
SNPs and haplotypes from RIPK2 were associated with tick burden in both dairy and beef cattle.
Genetic mapping of RIPK2 in cattle.
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.
receptor-interacting serine-threonine kinase 2
, receptor-interacting serine/threonine-protein kinase 2-like
, receptor-interacting serine/threonine-protein kinase 2
, tyrosine-protein kinase RIPK2
, CARD-carrying kinase
, CARD-containing IL-1 beta ICE-kinase
, CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase
, growth-inhibiting gene 30
, receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase
, receptor-interacting protein 2
, receptor (TNFRSF)-interacting serine-threonine kinase 2