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This study provides both genetic and functional evidence that transcellular epithelial calcium uptake via TRPV5-6 is vital to sustain life and enable bone formation.
These results suggest that the zECaC plays a key role in Ca(2 (show CA2 Proteins)+) absorption in developing zebrafish.
TRPV6 and CaBP (show S100G Proteins)-9k are expressed during pregnancy in the bovine uterine endometrium and placentomes, suggesting a functional role for these proteins in Ca2 (show CA2 Proteins)+ metabolism during pregnancy.
TRPV5 (show TRPV5 Proteins) and TRPV6 were upregulated with time and passage in culture suggesting that a shift in the phenotype of the cells in monolayer culture alters the expression of these channels.
TRPV6 mRNA levels were similar in the duodenum, kidney and heart of Equus caballus. Protein expression followed a similar pattern.
this review describes the role of TRPV6 in male fertility and cancer
High TRPV6 expression is associated with development and progression of pancreatic cancer.
cryo-electron microscopy structures of human TRPV6 in the open and closed states
TRPV5 (show TRPV5 Proteins) and TRPV6 lack a positively charged residue in the TM4 (show TPM4 Proteins)-TM5 loop that was shown to interact with PI(4,5)P2 in TRPV1 (show TRPV1 Proteins), which shows high affinity for this lipid
TRPV6 down-regulation is associated with decreased Ca(2 (show CA2 Proteins)+) response pattern and reduced NFAT (show NFATC1 Proteins) activity.
TRPV6 expression is significantly decreased in chondrocytes from patients with osteoarthritis of the knees. TRPV6 could regulate certain chondrocyte functions, including ECM secretion, cell proliferati (show MMRN1 Proteins)on, and apoptosis.
The findings indicate that p38alpha (show MAPK14 Proteins) and GADD45alpha (show GADD45A Proteins) are involved in an enhanced vitamin D signaling on TRPV6 expression.
TRPV6 is down-regulated in esophageal squamous cell carcinoma and plays a role in predicting survival of male and female patients.
These results suggest that CAT-1 is a novel CAM that directly regulates endothelial integrity and mediates the protective actions of L-Arg to endothelium via a NO-independent mechanism.
TRPV6 calcium ion channel plays a critical role in flow-induced Ca(2 (show CA2 Proteins)+) influx and microvilli formation.
Study suggest that amyloid beta-protein increase the expression of TRPC6 (show TRPC6 Proteins) via NF-kappaB (show NFKB1 Proteins) in BV-2 microglia and promotes the production of COX-2, which induces hippocampus neuron damage.
Study showed that TRPV6-expressing elements seem to be discretely organized in the brain of mouse. TRPV6-immunoreactive arcuate neurons co-express estrogen receptor alpha (show ESR1 Proteins) and the ion channel protein (show TRPC3 Proteins) expression in the mediobasal hypothalamus showed correlation with estrous cycle.
TRPV6-/- mice spontaneously developed osteoarthritis at a younger age and had more severe manifestations of OA than wild-type controls. TRPV6 could regulate certain chondrocyte functions, including ECM (show MMRN1 Proteins) secretion, cell proliferation, and apoptosis.
TRPV6 plays an essential role in bone metabolism and is a critical regulator in osteoclasts differentiation and bone resorption.
CAT1 (show SLC7A1 Proteins) overexpression prevents obesity-induced hypertension by reducing the influence of the SNS (show SCN10A Proteins) on the maintenance of arterial pressure but not by buffering pressor responses to stress.
Adra2a (show ADRA2A Proteins) is expressed in the mesenchyme of the mouse stomach primordium at E11.5. Fzd5 and Trpv6 are expressed in the epithelial layer of the stomach primordium after E11.5.
focus on TRPV6 gene polymorphisms, the start of TRPV6 translation at a non-AUG codon and the functions of TRPV6 in intestinal Ca(2 (show CA2 Proteins)+) uptake, sperm maturation, and male fertility.
these data indicate that obesity-induced down-regulation of CAT1 (show SLC7A1 Proteins) expression and subsequent reduced bioavailability of nitric oxide may contribute to the development of obesity-induced hypertension.
Fibroblasts from two long-lived mice mutants (Snell dwarf (show POU1F1 Proteins) and PAPP-A (show PAPPA Proteins) knockout) expressed higher levels of CAT1 (show SLC7A1 Proteins) (a ATF4 (show ATF4 Proteins) target gene) during stress, suggesting a connection to longevity.
A non-AUG start codon is used in both human and mouse, extending the N-terminus of the protein by 40 amino acids. The increased translation of the smaller TRPV6 cDNA version may overestimate the in vivo situation where translation efficiency may represent an additional mechanism to tightly control the TRPV6-mediated Ca(2 (show CA2 Proteins)+) entry to prevent deleterious Ca(2 (show CA2 Proteins)+) overload.
This gene encodes a member of the vanilloid family of transient receptor potential (TRP) calcium channel proteins. Proteins in this TRP family have an N-terminal ankyrin repeat domain, which is required for channel assembly and regulation.
epithelial calcium channel
, transient receptor potential cation channel subfamily V member 6
, transient receptor potential vanilloid 5-6
, transient receptor potential cation channel, subfamily V, member 6
, Alu-binding protein with zinc finger domain
, calcium transport protein 1
, calcium transporter-like protein
, epithelial apical membrane calcium transporter/channel CaT1
, epithelial calcium channel 2
, osmosensitive transient receptor potential channel 3
, transient receptor potential cation channel, subfamily 5, member 6