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A defective POT1 (show POT1 Proteins)-TPP1 (show TPP1 Proteins) complex leads to longer and fragile telomeres, which in turn promotes genomic instability and cancer.
several missense mutations in human cancers that disrupt the POT1C-TPP1 (show TPP1 Proteins) interaction, resulting in POT1 (show POT1 Proteins) instability, were identified.
the human POT1 (show POT1 Proteins)-TPP1 (show TPP1 Proteins) complex is a processivity factor for telomerase
UPF1 (show UPF1 Proteins) interacts with TPP1 (show TPP1 Proteins) and telomerase and sustains telomere leading-strand replication
Altered expression of TPP1 (show TPP1 Proteins) might contribute to persistent proliferation of fibroblast-like synovial cells in rheumatoid arthritis.
seven separation-of-function mutations map to a patch of amino acids on the surface of TPP1 (show TPP1 Proteins), the TEL (show ETV6 Proteins) patch, that both recruits telomerase to telomeres and promotes high-processivity DNA synthesis
Blocking TPP1 (show TPP1 Proteins) S111 phosphorylation by mutating residue S111 led to reduced telomerase association and telomere shortening.
Telomere damage and reduced TPP1 (show TPP1 Proteins) dimerization as a result of Akt (show AKT1 Proteins) inhibition was also accompanied by diminished recruitment of TPP1 (show TPP1 Proteins) and POT1 (show POT1 Proteins) to the telomeres.
Elevated expression of TPP1 (show TPP1 Proteins) in human colorectal cancer cells could protect telomere from DNA damage and confer radioresistance.
Down-regulation of TPP1 (show TPP1 Proteins) induced cell apoptosis in telomerase-negative osteosarcoma cell line.
Analyses demonstrate that the majority of differentially expressed genes in acd mutant embryos are due to p53 (show TP53 Proteins)-dependent mechanisms and reflect the observed phenotypic differences between acd mutant and double mutant embryos.
shelterin protein TIN2 (show TINF2 Proteins) can protect chromosome ends as a TRF2 (show TERF2 Proteins)-tethered TIN2 (show TINF2 Proteins)/TPP1 (show TPP1 Proteins)/POT1 (show POT1 Proteins) complex that lacks a physical connection to TRF1 (show TERF1 Proteins)
Mouse hematopoietic stem cells are acutely sensitive to inactivation of the shelterin gene Acd.
Tpp1 (show TPP1 Proteins) is required for the protective function of Pot1 (show POT1 Proteins) proteins.
Tumors from Acd(acd/acd) p53 (show TP53 Proteins)(+/-) mice show a striking switch from the classic spectrum of p53 (show TP53 Proteins)(-/-) mice toward carcinomas.
This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.
POT1 and TIN2 organizing protein
, POT1 and TIN2-interacting protein
, TIN2 interacting protein 1
, adrenocortical dysplasia protein homolog
, adrenocortical dysplasia homolog (mouse)
, adrenocortical dysplasia protein