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Full name:: Adrenocortical Dysplasia Homolog (Mouse) Proteins (ACD)

On www.antibodies-online.com are 12 Adrenocortical Dysplasia Homolog (Mouse) (ACD) Proteins from 6 different suppliers available. Additionally we are shipping ACD Antibodies (84) and ACD Kits (23) and many more products for this protein. A total of 129 ACD products are currently listed.

Synonyms:: ACD, PIP1, PTOP, TINT1, TPP1

list all proteins	Gene Name	GeneID	UniProt
	ACD	65057	Q96AP0
	ACD	307798	Q4FZR5
	ACD	497652	Q5EE38
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ACD Proteins (ACD) by Origin

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Relevant Pathways for ACD Proteins

Telomere Maintenance

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More Proteins for ACD Interaction Partners

Human Adrenocortical Dysplasia Homolog (Mouse) (ACD) interaction partners

the human POT1 (show POT1 Proteins)-TPP1 (show TPP1 Proteins) complex is a processivity factor for telomerase
UPF1 (show UPF1 Proteins) interacts with TPP1 (show TPP1 Proteins) and telomerase and sustains telomere leading-strand replication
Altered expression of TPP1 (show TPP1 Proteins) might contribute to persistent proliferation of fibroblast-like synovial cells in rheumatoid arthritis.
seven separation-of-function mutations map to a patch of amino acids on the surface of TPP1 (show TPP1 Proteins), the TEL (show ETV6 Proteins) patch, that both recruits telomerase to telomeres and promotes high-processivity DNA synthesis
Blocking TPP1 (show TPP1 Proteins) S111 phosphorylation by mutating residue S111 led to reduced telomerase association and telomere shortening.
Telomere damage and reduced TPP1 (show TPP1 Proteins) dimerization as a result of Akt (show AKT1 Proteins) inhibition was also accompanied by diminished recruitment of TPP1 (show TPP1 Proteins) and POT1 (show POT1 Proteins) to the telomeres.
Elevated expression of TPP1 (show TPP1 Proteins) in human colorectal cancer cells could protect telomere from DNA damage and confer radioresistance.
Down-regulation of TPP1 (show TPP1 Proteins) induced cell apoptosis in telomerase-negative osteosarcoma cell line.
G-quadruplex formation of telomeres significantly enhances the ability of POT1 (show POT1 Proteins)/TPP1 (show TPP1 Proteins) to block RPA's access to telomeres.
TPP1 (show TPP1 Proteins) has recently emerged as a primary contributor in protecting telomere DNA and in recruiting telomerase to the telomere ends. (Review)

Mouse (Murine) Adrenocortical Dysplasia Homolog (Mouse) (ACD) interaction partners

shelterin protein TIN2 (show TINF2 Proteins) can protect chromosome ends as a TRF2 (show TERF2 Proteins)-tethered TIN2 (show TINF2 Proteins)/TPP1 (show TPP1 Proteins)/POT1 (show POT1 Proteins) complex that lacks a physical connection to TRF1 (show TERF1 Proteins)
Mouse hematopoietic stem cells are acutely sensitive to inactivation of the shelterin gene Acd.
Tpp1 (show TPP1 Proteins) is required for the protective function of Pot1 (show POT1 Proteins) proteins.
Tumors from Acd(acd/acd) p53 (show TP53 Proteins)(+/-) mice show a striking switch from the classic spectrum of p53 (show TP53 Proteins)(-/-) mice toward carcinomas.

ACD Protein Profile

Protein Summary

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.

Alternative names and synonyms associated with ACD

ACD, shelterin complex subunit and telomerase recruitment factor (ACD)
ACD, shelterin complex subunit and telomerase recruitment factor (Acd)
adrenocortical dysplasia (Acd)

ACD protein
PIP1 protein
PTOP protein
TINT1 protein
TPP1 protein

Protein level used designations for ACD

POT1 and TIN2 organizing protein , POT1 and TIN2-interacting protein , TIN2 interacting protein 1 , adrenocortical dysplasia protein homolog , adrenocortical dysplasia homolog (mouse) , adrenocortical dysplasia protein

GENE ID	SPECIES
65057	Homo sapiens
307798	Rattus norvegicus
487931	Canis lupus familiaris
510353	Bos taurus
699230	Macaca mulatta
769451	Gallus gallus
497652	Mus musculus
100346875	Oryctolagus cuniculus

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