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anti-Human PCNA Antibodies:
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Human Monoclonal PCNA Primary Antibody for ICC, IHC (fro) - ABIN3044483
Tian, Wei, Li, Wang, Zhang, Xie: Pathway of programmed cell death and oxidative stress induced by ?-hydroxybutyrate in dairy cow abomasum smooth muscle cells and in mouse gastric smooth muscle. in PLoS ONE 2014
Show all 98 Pubmed References
Chicken Monoclonal PCNA Primary Antibody for ChIP, ELISA - ABIN152935
Waseem, Lane: Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form. in Journal of cell science 1990
Show all 25 Pubmed References
Human Polyclonal PCNA Primary Antibody for IHC, WB - ABIN6711875
Chen, Xue, Niu, Ma, Li, Cao, Li, Wang, Zhao, Li, Wang, Tong: The retinoblastoma protein selectively represses E2F1 targets via a TAAC DNA element during cellular senescence. in The Journal of biological chemistry 2013
Show all 7 Pubmed References
Human Polyclonal PCNA Primary Antibody for IHC - ABIN966812
Kweekel, Antonini, Nortier, Punt, Gelderblom, Guchelaar: Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. in British journal of cancer 2009
Show all 6 Pubmed References
Hamster Monoclonal PCNA Primary Antibody for IF, IP - ABIN334654
Rottach, Kremmer, Nowak, Boisguerin, Volkmer, Cardoso, Leonhardt, Rothbauer: Generation and characterization of a rat monoclonal antibody specific for PCNA. in Hybridoma (2005) 2008
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Human Polyclonal PCNA Primary Antibody for IHC - ABIN966811
Niwa, Miwa, Kuzuya, Iwasaki, Haneda, Ueki, Katayama, Hiramitsu, Goto, Nagasaka, Watarai, Uchida, Nakao, Kobayashi: Stimulation index for PCNA mRNA in peripheral blood as immune function monitoring after renal transplantation. in Transplantation 2009
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Human Monoclonal PCNA Primary Antibody for ICS - ABIN2689878
Schlatt, Weinbauer: Immunohistochemical localization of proliferating cell nuclear antigen as a tool to study cell proliferation in rodent and primate testes. in International journal of andrology 1995
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Human Polyclonal PCNA Primary Antibody for IF, IHC (p) - ABIN389344
Wang, Zheng, Luo, Fan, Chen, Zhang, Hui: KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation. in Journal of cellular biochemistry 2009
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Human Polyclonal PCNA Primary Antibody for ICC, FACS - ABIN151904
Ramos-Nino, Blumen, Sabo-Attwood, Pass, Carbone, Testa, Altomare, Mossman: HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway. in American journal of respiratory cell and molecular biology 2008
Show all 4 Pubmed References
Human Polyclonal PCNA Primary Antibody for IF (p), IHC (p) - ABIN672756
Song, Yan, An, Hao, Guo, Zhang, Li, Li, Sun: Potential contribution of SOCC to cerebral vasospasm after experimental subarachnoid hemorrhage in rats. in Brain research 2013
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PCNA recognizes the DNA structure through a set of basic residues within the ring channel organized to match the pitch of B-DNA, establishing short-lived polar interactions with consecutive DNA phosphates.
Results show that HECW2 interacts with PCNA mediating its ubiquitination and proteasomal degradation.
It has been shown that conjugation of SUMO2, but not SUMO1 or SUMO3, to the essential replication factor PCNA is induced on transcribed chromatin by the RNAPII-bound helicase RECQ5.
This study identified PCNA-peptide interactions formed in the peptide bound simulation that play a crucial role in complex formation. The calculated binding energies correlate well with the measured binding affinities of various peptides to PCNA.
Results suggest that CDK-mediated phosphorylation of Cdt2 inactivates its ubiquitin ligase activity by reducing its affinity to PCNA, an important strategy for regulating the levels of key proteins in the cell cycle.
CHAF1A and PCNA are highly expressed in cervical squamous cell carcinoma and associated with the malignancy
DDB2-PCNA interaction may contribute to a correct DNA damage response for maintaining genome integrity
this study shows that cytoplasmic PCNA connects glycolysis and cell survival in acute myeloid leukemia
The results revealed that PCNA is predominantly localized in the cytoplasm, while hAng is distributed both in the nucleus and in the cytoplasm. hAng and PCNA colocalize in the cytoplasm, suggesting that they may interact in this compartment.
PCNA and E-cadherin may have roles in prognosis of patients with gastric cancer
PCNA and MutLalpha interact specifically but weakly in solution to form a complex of approximately 1:1 stoichiometry that depends on PCNA interaction with the C-terminal endonuclease domain of the MutLalpha PMS2 subunit.
FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2
Treatment with 240 mg/l matrine reduced the protein expression levels of PCNA and eIF4E. Matrine also reduced the migration ability of A549 cells and inhibited their proliferation, which may be associated with the overexpression of p53 and p21, and the reduction of PCNA and eIF4E expression levels.
The here presented evidence that the PCNA inner surface is highly regulated to control DNA damage resistance represents a new concept that offers new opportunities to develop tools to manipulate the DNA damage response in cancer treatment. [review]
Data suggest that, as part of DNA repair in nucleus of embryonic stem cells, IGF1R interacts with and phosphorylates PCNA at tyrosine residues 60, 133, and 250; this is followed by mono- and polyubiquitination of PCNA by RAD18 and SHPRH. (IGF1R = insulin-like growth factor 1 receptor; PCNA = proliferating cell nuclear antigen; RAD18 = E3 ubiquitin-protein ligase RAD18; SHPRH = E3 ubiquitin-protein ligase SHPRH)
Here, we report the complex structure of PCNA and the peptide ((784)NEILQTLLDLFFPGYSK(800)) derived from UHRF2 that contains a PIP box. Structural analysis combined with mutagenesis experiments provide the molecular basis for the recognition of UHRF2 by PCNA via PIP-box.
The complex between p15PAF and trimeric PCNA is of low affinity, forming a transient complex that is difficult to characterize at a structural level due to its inherent polydispersity. We have determined the structure, conformational fluctuations, and relative population of the five species that coexist in solution by combining small-angle X-ray scattering (SAXS) with molecular modelling.
Dynamic binding of the PARG non-canonical PIP-box to PCNA.
PCNA expression significantly associated with clinical stage, histological grade, and poor prognosis of Osteosarcoma, which could evaluate tumor cell proliferation, and predict its biological behavior and prognosis.
These results propose a mechanism for progerin-induced genome instability and accelerated replicative senescence in Hutchinson-Gilford progeria syndrome.
The first evidence for non-repair functions of MGMT in cell cycle and highlight the involvement of PCNA in MGMT downregulation, with p21 attenuating the process.
e results showed mTet1 modified mGSCs had better self-renewal and proliferation ability than wild-type mGSCs, mTet1 could also up-regulate JMJD3 to decrease H3K27me3, which also showed to suppress the MEK-ERK pathway. Furthermore, Co-IP analysis demonstrated that TET1 interact with PCNA and HDAC1 by forming protein complexes to comprehensively regulate dairy goat mGSCs and spermatogenesis.
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF/NF-kappaB-regulated apoptosis and the p53/PCNA- and ATM/ATR-Chk1/2-controlled DNA-damage response pathways.
REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.
PCNA was mainly localized in decidual-stromal cells.
up-regulated expression during benzo(a)pyrene induced pulmonary carcinogenesis
Luteolin may inhibit tumor angiogenesis and tumor cell proliferation by down-regulation of LFA- 3 and PCNA and up-regulation of ICAM-1 in tumor tissue of tumor-bearing mice, thereby achieving its anti-tumor effect.
Data suggest Usp1 (ubiquitin specific peptidase 1) down-regulation by autocleavage is critical for Usp1 to exert role in DNA interstrand crosslink repair; Usp1 role is de-ubiquitination of Pcna and Fancd2 (Fanconi anemia complementation group D2).
The aberrant DNA replication mediated by the PCNA-DNA pol-beta complex induces p53-dependent neuronal cell death
Demonstrate that miR-376a regulates primordial follicle assembly by modulating the expression of Pcna.
while interaction with PCNA was important for targeting p21 to the CRL4Cdt2 ligase re-localized to MVM replication centers
Styrax japonica glycoprotein increased diethylnitrosamine-induced PCNA activity.
This study identifies a critical role for PCNA in adipose tissue development, and for the first time identifies a role of the core DNA replication machinery at the interface between proliferation and differentiation.
Seaweed pigment glycoprotein reduced the expression of PCNA and Bcl2, which reduced proliferation of hepatocarcinoma cells.
These results suggest that the ncRNA is divergently transcribed from the bidirectional promoter, positively regulating the neighboring protein-coding Pcna gene transcription, and this regulatory function is somehow disrupted in cancer cells.
these data support the existence of PCNA ubiquitination-dependent and -independent activation pathways of Poleta during somatic hypermutation and DNA damage tolerance.
Taken together these results indicate that PCNA-ubiquitination is required for maximal translesion DNA synthesis.
FFAA Fen1 mutation causes defective Pcna -coordinated Okazaki fragment maturation.
Stress treatment of mouse cells with ethanol or hydrogen peroxide caused the re-distribution of MSH3 into nuclear bodies containing the proliferating cell nuclear antigen (PCNA), a known binding partner of MutSbeta.
PCNA was shown to be differentially expressed during during primordial follicle assembly in mouse ovaries
tomato DDI2 gene is required for UV-induced DNA damage repair and plant tolerance to UV stress. [DDI2]
Results show that regulation of e2f1 and PCNA by DREF in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
crystal of DmPCNA diffracted to 2.0 A resolution and belonged to space group H3, with unit-cell parameters a = b = 151.16, c = 38.28 A
We observed that SUUR chromosomal localization changed along with PCNA pattern and these proteins largely co-localized during the late S-phase in salivary glands.
E2F regulation of PCNA is dispensable for viability, but is nonetheless important for normal Drosophila development.
A Q123V mutation dramaticly enhances the abilities of Drosophila PCNA to stimulate calf thymus pol delta. Replacing the entire interdomain connector loop AA 119-133 with the corresponding residues from human PCNA results in additional enhancement.
The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2, wee1, p21, PCNA and cdk2, but only weakly influences cyclin B1, cyclin B2 and cyclin E1 expression.
residue in PCNA that is essential to support destruction of all CRL4(Cdt2) substrates
CRL4Cdt2 ubiquitin ligase directly associates with pcna through its C-terminal domain.
PCNA monoubiquitylation serves as a molecular gas pedal that controls the speed of replisome movement during S phase.
Immunodepletion of Swift PAX-interacting protein 1 from Xenopus extracts prevented efficient PCNA ubiquitination
PCNA docking activates the pre-formed Cdt1-Cul4(DDB1) ligase complex. Thus, PCNA functions as a platform for Cdt1 destruction, ensuring efficient and temporally restricted inactivation of a key cell-cycle regulator.
There is a link between the intestinal detoxification system (CYP1A) & cell renewal system (PCNA). These two processes are inversely correlated in beta-naphthoflavone- exposed fish
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
DNA polymerase delta auxiliary protein
, proliferating cell nuclear antigen
, proliferating-cell nuclear antigen
, proliferating cell nuclear antigen subtype1
, proliferating cell nuclear antigen subtype2
, proliferating cell nuclear antigen subtype3
, proliferative cell nuclear antigen