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The expression level of RFC3 was markedly upregulated in the HCC (show FAM126A Proteins) tissues and cells.
The expression level of RFC3 was remarkably up-regulated in ovarian cancer OVCAR-3 cells. Down-regulation of RFC3 expression arrested the cell cycle of OVCAR-3 cell in the S-phase and induced apoptosis.
High RFC3 expression is associated with neoplastic myelopoiesis.
our findings suggest that RFC3 protein is an important and independent biomarker with prognostic implications for patients with ovarian carcinoma.
9-cis-RA-activated RXRalpha (show RXRA Proteins) suppresses the growth of retinoid-sensitive breast cancer and embryonic cells through RFC3.
Data identified RFC3 as a candidate oncogene (show RAB1A Proteins) amplified in esophageal adenocarcinoma (EAC (show CYLD Proteins)).
RFC3 mutation and loss of RFC3 expression occur in large fractions of gastric and colorectal cancers and suggest that these alterations may contribute to the cancer pathogenesis by deregulating DNA repair and replication.
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described.
replication factor C subunit 3
, drosophila replication factor C
, replication factor C3
, A1 38 kDa subunit
, RF-C 38 kDa subunit
, activator 1 38 kDa subunit
, activator 1 subunit 3
, replication factor C 3
, replication factor C 38 kDa subunit
, replication factor C, 38 kDa
, RFC, 38 kD subunit