Browse our anti-ATF4 (ATF4) Antibodies

Full name:: anti-Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) Antibodies (ATF4)

On www.antibodies-online.com are 306 Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) Antibodies from 29 different suppliers available. Additionally we are shipping ATF4 Kits (17) and ATF4 Proteins (16) and many more products for this protein. A total of 360 ATF4 products are currently listed.

Synonyms:: Atf-4, atf4, atf4-a, atf4-b, ATF4-I, atf4-ii, C/ATF, creb-2, creb2, sb:eu681, taxreb67, txreb, wu:fb08f07, wu:fj01c08, wu:fk30b04, zgc:85951, zgc:171702

list all antibodies	Gene Name	GeneID	UniProt
	ATF4	468	P18848
	ATF4	79255	Q9ES19
	ATF4	11911	Q06507
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anti-Mouse (Murine) ATF4 Antibodies:

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Top referenced anti-ATF4 Antibodies

Human Monoclonal ATF4 Primary Antibody for IF, ELISA - ABIN559979 : Meister, Frey, Lang, Gaipl, Schett, Schlötzer-Schrehardt, Voll: Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells. in Neoplasia (New York, N.Y.) 2010 (PubMed)
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Mouse (Murine) Polyclonal ATF4 Primary Antibody for IHC, WB - ABIN2779918 : Smith, Schmechel, Raghavan, Abelson, Reilly, Katze, Kaufman, Bohjanen, Schiff: Reovirus induces and benefits from an integrated cellular stress response. in Journal of virology 2006 (PubMed)
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Human Polyclonal ATF4 Primary Antibody for IF (p), IHC (p) - ABIN687862 : Jiang, Ren, Jiang, Wang, Zhang, Yin, Wang, Qi, Wang, Feng: Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. in Neuroscience 2014 (PubMed)
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Human Polyclonal ATF4 Primary Antibody for IF (p), IHC (p) - ABIN756172 : Jiang, Yun, Shi, Niu, Gao, Xie, Yu: Downregulation of miR-384-5p attenuates rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through inhibiting endoplasmic reticulum stress. in American journal of physiology. Cell physiology 2016 (PubMed)
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Human Polyclonal ATF4 Primary Antibody for ELISA, WB - ABIN257681 : Tsujimoto, Nyunoya, Morita, Sato, Shimotohno: Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. in Journal of virology 1991 (PubMed)
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Cow (Bovine) Polyclonal ATF4 Primary Antibody for WB - ABIN2780377 : Kalinec, Thein, Parsa, Yorgason, Luxford, Urrutia, Kalinec: Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways. in Hearing research 2014 (PubMed)
Human Polyclonal ATF4 Primary Antibody for IHC - ABIN965616 : Yang, Matsuda, Bialek, Jacquot, Masuoka, Schinke, Li, Brancorsini, Sassone-Corsi, Townes, Hanauer, Karsenty: ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. in Cell 2004 (PubMed)
Human Polyclonal ATF4 Primary Antibody for ICC, IF - ABIN4282025 : Oh, Pan, Yalcin, Zhang, Guilarte, Hotamisligil, Christiani, Lu: Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress. in The Journal of biological chemistry 2012 (PubMed)

More Antibodies against ATF4 Interaction Partners

Human Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

results suggest a conditional regulation of KRT16 gene by ATF4 that may be inhibited in normal cells, but engaged during cancer progression. Potential roles of KRT16, FAM129A and HKDC1 genes upregulation in adaptive stress responses and pathologies are discussed
Results provide evidence that the availability of glucose controls ATF4-mediated MITF (show MITF Antibodies) suppression to drive melanoma cell proliferation.
Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells
These results suggest that p21 (show CDKN1A Antibodies) induction plays a vital role in the cellular response to ER stress and indicate that p21 (show CDKN1A Antibodies) is a prosurvival effector of ATF4.
GRP78 (show HSPA5 Antibodies) inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP (show DDIT3 Antibodies) in human osteosarcoma cells.
Expression of either dominant-negative or constitutively active mutants of Nrf2 (show GABPA Antibodies), ATF4, or c-Jun (show JUN Antibodies) confirmed that distinct transcription units are regulated by these transcription factors.
ATF4 contributes to tumor growth of endometrial cancer (EC) by promoting CCL2 (show CCL2 Antibodies) and subsequent recruitment of macrophage, and ATF4/CCL2 (show CCL2 Antibodies) axis might be a potential therapeutic target for EC.
ATF4 expression fosters the malignancy of primary brain tumors and increases proliferation and tumor angiogenesis; experiments revealed that ATF4-dependent tumor promoting effects are mediated by transcriptional targeting the glutamate (show GRIN1 Antibodies) antiporter xCT (show SLC7A11 Antibodies)
The PERK (show EIF2AK3 Antibodies)-eIF2alpha (show EIF2A Antibodies)-ATF4-CHOP (show DDIT3 Antibodies) signaling pathway has a critical role in tumor progression during endoplasmic reticulum stress. (Review)
ATF4 pathway is activated in vivo upon mitochondrial stress.

Rhesus Monkey Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

HIV/SIV exploits the early host antiviral response through GCN2 (show EIF2AK4 Antibodies)-ATF4 signaling by utilizing ATF4 for activating the viral LTR transcription to establish initial viral replication

Pig (Porcine) Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

expression levels of porcine ATF4 gene were up-regulated 60 days and 120 days after birth in both breeds and the expression level in Meishan pigs was obviously higher than that in Large White pigs
Tissue transcription analysis revealed that both porcine CREB2 (show ATF2 Antibodies) and CREB3 (show CREB3 Antibodies) mRNA were ubiquitously detected in all examined tissues.

Xenopus laevis Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

Over-expression of atf4 in embryos interferes with neurogenesis and eye formation.
Unlike other CREB2 (ATF4) proteins, the ATF4 isolated from the gonads of Xenopus embryos contains a consensus phosphorylation site for protein kinase A (PKA).

Mouse (Murine) Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

these findings reveal a new crucial combined effect of the silencing of PERK (show EIF2AK3 Antibodies) and ATF4 in modulating ER stressmediated apoptosis during chondrocyte differentiation and proliferation.
Sirt1 (show SIRT1 Antibodies) reduced endoplasmic reticulum stress and apoptosis of brown adipocytes in vivo/in vitro by inhibiting Smad3 (show SMAD3 Antibodies)/ATF4 signaling pathway.
These findings indicate that the aggregation of S-opsin (show OPN1SW Antibodies) induced by exposure to blue -emitting diode light causes endoplasmic reticulum stress, and ATF4 activation in particular.
We hypothesize that the essential role of methionine-charged initiator tRNA in forming ternary complex is responsible for the robust ability of methionine deficiency to induce ATF4 and the ISR even in the absence of GCN2 (show EIF2AK4 Antibodies) or eIF2alpha (show EIF2A Antibodies) kinase activity.
BTG1 (show BTG1 Antibodies) has a role in regulating hepatic lipid metabolism and in preventing ATF4 and SCD1 (show SCD Antibodies) from inducing liver steatosis
Transcriptional profiling reveals that mouse neuroblastoma (show ARHGEF16 Antibodies) sphere-forming cells acquire a metabolic program characterized by transcriptional activation of the cholesterol and serine-glycine synthesis pathways, primarily as a result of increased expression of sterol regulatory element binding factors and Atf4, respectively
MIF-2 (show HSPA5 Antibodies)/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI (show SLPI Antibodies)- and ATF4-dependent mechanisms.
ATF4 has a role in gene expression during basal conditions, with 385 genes altered by the loss of ATF4 in the absence of apparent stress. Deletion of ATF4 alters genes that are required for the conversion of cholesterol to bile acid (CYP7A1 (show CYP7A1 Antibodies)), esterification of cholesterol (SOAT2 (show SOAT2 Antibodies)), and transport from the hepatocyte (ABCA1 (show ABCA1 Antibodies)); when ATF4 loss is coupled with ER stress, results in increase in free cholesterol within hepatocyte
ATF4 pathway is activated in vivo upon mitochondrial stress.
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a (show EIF2A Antibodies) phosphorylation by inhibiting PPP1CA (show PPP1CA Antibodies) via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 expression. (eIF2a (show EIF2A Antibodies) = eukaryotic initiation factor-2alpha (show EIF2S1 Antibodies); PPP1CA (show PPP1CA Antibodies) = protein phosphatase 1 catalytic subunit alpha; Atf4 = activating transcription factor 4)

ATF4 Antigen Profile

Antigen Summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.

Alternative names and synonyms associated with ATF4

activating transcription factor 4 (ATF4) antibody
activating transcription factor 4 (atf4) antibody
activating transcription factor 4 (Atf4) antibody
activating transcription factor 4 L homeolog (atf4.L) antibody
activating transcription factor 4a (atf4a) antibody
activating transcription factor 4b (atf4b) antibody
activating transcription factor 4 S homeolog (atf4.S) antibody

Atf-4 antibody
atf4 antibody
atf4-a antibody
atf4-b antibody
ATF4-I antibody
atf4-ii antibody
C/ATF antibody
creb-2 antibody
creb2 antibody
sb:eu681 antibody
taxreb67 antibody
txreb antibody
wu:fb08f07 antibody
wu:fj01c08 antibody
wu:fk30b04 antibody
zgc:85951 antibody
zgc:171702 antibody

Protein level used designations for ATF4

DNA-binding protein TAXREB67 , cAMP response element-binding protein 2 , cAMP-dependent transcription factor ATF-4 , cAMP-responsive element-binding protein 2 , cyclic AMP-dependent transcription factor ATF-4 , cyclic AMP-responsive element-binding protein 2 , tax-responsive enhancer element B67 , tax-responsive enhancer element-binding protein 67 , activating transcription factor 4 (tax-responsive enhancer element B67) , activating transcription factor ATF-4 , rATF-4 , activating transcription factor 4 , c/EBP-related ATF , tax-responsive enhancer element-binding protein 67 homolog , taxREB67 homolog , Activating Transcription Factor 4 -I , Activating Transcription Factor 4 -II , activating transcription factor 4 S homeolog

GENE ID	SPECIES
468	Homo sapiens
100216465	Ovis aries
395693	Gallus gallus
703965	Macaca mulatta
474503	Canis lupus familiaris
744513	Pan troglodytes
100144302	Sus scrofa
448005	Xenopus (Silurana) tropicalis
79255	Rattus norvegicus
398804	Xenopus laevis
406514	Danio rerio
509107	Bos taurus
556410	Danio rerio
11911	Mus musculus
100732296	Cavia porcellus
101680524	Mustela putorius furo
734165	Xenopus laevis

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Show all anti-Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) Antibodies with Pubmed References