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Human TTF-I localizes in the nucleolus and N-terminus (1-224) of hTTF-I which include nucleolus localization sequence and the expression of Human TTF-I 521-732 increased HIV-I production by regulating transactivation of the LTR promoter.
These findings collectively suggest that the triple combination of survivin knockdown with ABT-263 and trametinib treatment, may be a potential strategy for the treatment of KRAS-mutant lung adenocarcinoma. Furthermore, our findings indicate that the welldifferentiated type of KRAS-mutant lung tumors depends, at least in part, on TTF1 (show NKX2-1 Proteins) for growth.
TTF-1 (show NKX2-1 Proteins) expression may serve as a predictive marker to identify lung cancer patients who may benefit from the addition of bevacizumab to platinum doublet therapy.
Our results showed that an approach of using only a two-antibody panel (p40 and TTF-1) might help in reduction of diagnostic category of NSCLC-NOS significantly and contribute in saving tissue for future molecular testing
Single nucleotide polymorphism in TTF1 (show NKX2-1 Proteins) gene is associated with Systemic lupus erythematosus
Case Report: KRAS mutation-positive bronchial surface epithelium type lung adenocarcinoma with strong expression of TTF-1 (show NKX2-1 Proteins).
Overexpression of Transcription Termination Factor 1 is Associated with Colorectal Cancer
Depletion of TTF-I recapitulates the effects of ARF on ribosomal RNA synthesis and is rescued by the introduction of a TTF-I transgene.
Together with results showing involvement of TTF-1 (show NKX2-1 Proteins) in the TNF-alpha (show TNF Proteins)-induced increase in interleukin 1 beta (show IL1B Proteins) and monocyte chemotactic protein 1 (show CCL2 Proteins) production, this study suggests that TTF-1 (show NKX2-1 Proteins) plays an important role in the mouse hypothalamus TNF-alpha (show TNF Proteins)-induced inflammatory response for regulating HO-1 (show HMOX1 Proteins) gene expression.
this study shows that in a mouse model of thyrocyte hyperplasia, proliferating thyrocytes were thyroid transcription factor (TTF1 (show NKX2-1 Proteins))-positive
TTF-1 (show NKX2-1 Proteins) is expressed in lung during different stages of development.
Interaction of TTF-I with target sites upstream and downstream of the rDNA transcription unit connects these distal DNA elements by forming a chromatin loop between the rDNA promoter and the terminators.
ErbB4 is a critical upstream regulator of TTF-1 in type II epithelial cells and that this interaction is important for Sftpb regulation.
Otp (show OTP Proteins) and TTF-1 (show NKX2-1 Proteins) are essential for the normal morphological development of the hypothalamus, including the arcuate nucleus [review]
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression.
transcription termination factor 1
, RNA polymerase I termination factor
, transcription termination factor I