Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Mouse (Murine) SARM1 Antibodies:
anti-Human SARM1 Antibodies:
anti-Rat (Rattus) SARM1 Antibodies:
Go to our pre-filtered search.
Human Polyclonal SARM1 Primary Antibody for ELISA, ICC - ABIN4352013
Murata, Sakaguchi, Kataoka, Huh: SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria. in Molecular biology of the cell 2013
Human Polyclonal SARM1 Primary Antibody for ICC, IF - ABIN4352017
Rodet, Tasiemski, Boidin-Wichlacz, Van Camp, Vuillaume, Slomianny, Salzet: Hm-MyD88 and Hm-SARM: two key regulators of the neuroimmune system and neural repair in the medicinal leech. in Scientific reports 2015
Hence, pro-degenerative MAPK (show MAPK1 Antibodies) signaling functions upstream of SARM1 by limiting the levels of the essential axonal survival factor NMNAT2 (show NMNAT2 Antibodies) to promote injury-dependent SARM1 activation.
we identify a physical interaction between the autoinhibitory N terminus and the TIR domain of SARM1, revealing a previously unrecognized direct connection between these domains that we propose mediates autoinhibition and activation upon injury.
Using steady-state and flux analysis of NAD(+) metabolites in healthy and injured mouse dorsal root ganglion axons, we find that rather than altering NAD(+) synthesis, NMNAT1 (show NMNAT1 Antibodies) instead blocks the injury-induced, SARM1-dependent NAD(+) consumption that is central to axon degeneration.
demonstrate that the NADase activity of full-length SARM1 is required in axons to promote axonal NAD+ depletion and axonal degeneration after injury.
Genetic deletion of SARM1 decreases axonal degeneration in a mouse model of neuropathy.
SARM is a potential regulator of sepsis-induced splenocyte apoptosis.
Sarm1(-/-)mice developed fewer Beta-amyloid precursor protein aggregates in axons of corpus callosum after traumatic brain injury.
MMP-12 (show MMP12 Antibodies) up-regulation mediated by SARM-TRIF (show RNF138 Antibodies) signaling pathway contributes to IFN-gamma (show IFNG Antibodies)-independent airway inflammation and AHR (show AHR Antibodies) post RSV infection in nude mice.
SARM1, Not MyD88 (show MYD88 Antibodies), Mediates TLR7 (show TLR7 Antibodies)/TLR9 (show TLR9 Antibodies)-Induced Apoptosis in Neurons
nicotinamide mononucleotide adenylyltransferase 2 (show NMNAT2 Antibodies)-depletion-dependent degeneration of established axons and restricted extension of developing axons are thus both SARM1 dependent
Active nerve degeneration requires SARM1 and MAP kinases, including DLK (show DAPK3 Antibodies), while the NAD+ synthetic enzyme NMNAT2 (show NMNAT2 Antibodies) prevents degeneration.
Data show that sterile alpha- and armadillo-motif-containing protein (SARM) modulates MyD88 protein-mediated Toll-like receptors (TLRs) activation through BB-loop dependent interleukin-1 receptor (TIR) TIR-TIR interactions.
These results indicate that association of PINK1 (show PINK1 Antibodies) with SARM1 and TRAF6 (show TRAF6 Antibodies) is an important step for mitophagy.
The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling.
Rapid Wallerian degeneration requires the pro-degenerative molecules SARM1.
Data found that the UXT (show UXT Antibodies) isoforms elicit dual opposing regulatory effects on SARM-induced apoptosis.
SARM overexpression caused mitochondrial clustering which has also been observed in several cell death phenomenon.
The N-terminal 27 amino acids (S27 (show RPS27 Antibodies)) of SARM, which is hydrophobic and polybasic, acts as a mitochondria-targeting signal sequence, associating SARM to the mitochondria. The S27 (show RPS27 Antibodies) peptide has an inherent ability to bind to lipids and mitochondria.
SARM-mediated inhibition may not be exclusively directed at TRIF (show TRIM69 Antibodies) or MyD88 (show MYD88 Antibodies), but that SARM may also directly inhibit MAPK (show MAPK1 Antibodies) phosphorylation
Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation (By similarity).
sterile alpha and TIR motif-containing protein 1
, sterile alpha and TIR motif containing 1
, Tir-1 homolog
, SAM domain-containing protein 2
, sterile alpha and Armadillo repeat protein
, sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
, sterile alpha motif domain-containing protein 2
, tir-1 homolog