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anti-Human TAX1BP1 Antibodies:
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Human Polyclonal TAX1BP1 Primary Antibody for ICC, IF - ABIN4357936
Newman, Scholefield, Kemp, Newman, McIver, Kamal, Wilkinson: TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. in PLoS ONE 2012
Show all 2 Pubmed References
Human Polyclonal TAX1BP1 Primary Antibody for WB - ABIN1538392
Wang, Chen, Yeo, Karsli-Uzunbas, White, Mizushima, Virgin, Guan: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. in The Journal of cell biology 2016
Results show that TAX1BP1 translocates to mitochondria in response to RNA virus infection and inducibly interacts with the MAVS (show MAVS Antibodies) adaptor protein and indicate that TAX1BP1 functions as an adaptor molecule for Itch to target MAVS (show MAVS Antibodies) during RNA virus infection and thus restrict virus-induced apoptosis.
TAX1BP1 downregulation by EBV-miR (show MLXIP Antibodies)-BART15-3p enhances chemosensitivity of gastric cancer cells to 5-fluorouracil.
The induction of antibodies to an AQP4 (show AQP4 Antibodies) epitope in mice immunized with the TAX1BP1-derived peptide suggests that a latent HTLV-1 infection could lead to TAX1BP1 antigen presentation and the production of anti-AQP4 (show AQP4 Antibodies) antibodies in human neuromyelitis optica.
we demonstrate that myosin VI (show MYO6 Antibodies) and TAX1BP1 are recruited to ubiquitylated Salmonella and play a key role in xenophagy
A protein construct corresponding to the SKICH domain plus the linker region was expressed, purified and crystallized for TAX1BP1.
RNF11 (show RNF11 Antibodies) functions together with TAX1BP1 to restrict antiviral signaling and IFN-beta (show IFNB1 Antibodies) production.
Autophagy of Tax1bp1/Ndp52 (show CALCOCO2 Antibodies) promotes non-canonical NF-kappaB (show NFKB1 Antibodies) signalling.
Allele frequencies of three Alu insertions that are located in MEF2C (show MEF2C Antibodies) (two of them) and TAX1BP1 genes significantly differ between cohorts of healthy donors and ALL(acute lymphoblastic leukemia) patients.
ABIN1 (show TNIP1 Antibodies) requires its ubiquitin binding domain and cooperates with TAX1BP1 and A20 (show TNFAIP3 Antibodies) to restrict antiviral signaling.
In a link with T cell leukemia virus-1-associated myelopathy/tropical spastic paraparesis, an alphabeta T cell receptor recognizes a self peptide from neuronal protein (show LRCH1 Antibodies) HuD (show ELAVL4 Antibodies) in context of histocompatibility antigen HLA-A2.
TAX1BP1 overexpression promoted autophagic flux, as demonstrated by increased LC3 (show MAP1LC3A Antibodies)-RFP (show RFP Antibodies) fluorescence in vitro. Furthermore, the autophagy inhibitor 3 (show PPP1R11 Antibodies)-MA abolished the protective effects of TAX1BP1 in vivo.
These findings show that TAX1BP1 restricts ERK (show EPHB2 Antibodies) activation and Blimp-1 (show PRDM1 Antibodies) expression and regulates germinal center formation.
These studies reveal that TAX1BP1 drives a specialized form of autophagy, providing critical amino acids that activate mTOR (show FRAP1 Antibodies) and enable the metabolic transition of activated T cells.
The kinase IKKalpha (show CHUK Antibodies) inhibits activation of the transcription factor NF-kappaB (show NFKB1 Antibodies) by phosphorylating the regulatory molecule TAX1BP1.
Antibiotics-induced 'germ free' status or the additional MyD88 (show MYD88 Antibodies) deficiency significantly ameliorated TAX1BP1-KO mice's inflammatory lesions
results demonstrate TBK1 (show TBK1 Antibodies)-IKKi (show IKBKE Antibodies) to be novel substrates for A20 (show TNFAIP3 Antibodies) and further identify a novel mechanism whereby A20 (show TNFAIP3 Antibodies) and TAX1BP1 restrict antiviral signaling by disrupting a TRAF3 (show TRAF3 Antibodies)-TBK1 (show TBK1 Antibodies)-IKKi (show IKBKE Antibodies) signaling complex
TAX1BP1 is pivotal for the termination of NF-kappaB (show NFKB1 Antibodies) and JNK (show MAPK8 Antibodies) signaling by functioning as an essential regulator of A20 (show TNFAIP3 Antibodies).
TAX1BP1 is an essential adaptor for linking A20 (show TNFAIP3 Antibodies) to TRAF6 (show TRAF6 Antibodies) and other factors in order to influence NF-B activation.
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, tax1-binding protein 1
, TRAF6-binding protein homolog
, Tax1 (human T-cell leukemia virus type I) binding protein 1
, tax1-binding protein 1 homolog
, liver regeneration-related protein 2
, liver regeneration-related protein LRRG004
, tax1-binding protein 1 homolog B
, Tax1 binding protein 1
, muscle-derived protein 62
, tax1-binding protein 1 homolog A
, Tax1 (human T-cell leukemia virus type I) binding protein 1 L homeolog
, Tax1 binding protein 1 L homeolog