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These studies reveal that TAX1BP1 drives a specialized form of autophagy, providing critical amino acids that activate mTOR (show FRAP1 Proteins) and enable the metabolic transition of activated T cells.
The kinase IKKalpha (show CHUK Proteins) inhibits activation of the transcription factor NF-kappaB (show NFKB1 Proteins) by phosphorylating the regulatory molecule TAX1BP1.
The induction of antibodies to an AQP4 (show AQP4 Proteins) epitope in mice immunized with the TAX1BP1-derived peptide suggests that a latent HTLV-1 infection could lead to TAX1BP1 antigen presentation and the production of anti-AQP4 (show AQP4 Proteins) antibodies in human neuromyelitis optica.
Antibiotics-induced 'germ free' status or the additional MyD88 (show MYD88 Proteins) deficiency significantly ameliorated TAX1BP1-KO mice's inflammatory lesions
ABIN1 (show TNIP1 Proteins) requires its ubiquitin binding domain and cooperates with TAX1BP1 and A20 (show TNFAIP3 Proteins) to restrict antiviral signaling.
results demonstrate TBK1 (show TBK1 Proteins)-IKKi (show IKBKE Proteins) to be novel substrates for A20 (show TNFAIP3 Proteins) and further identify a novel mechanism whereby A20 (show TNFAIP3 Proteins) and TAX1BP1 restrict antiviral signaling by disrupting a TRAF3 (show TRAF3 Proteins)-TBK1 (show TBK1 Proteins)-IKKi (show IKBKE Proteins) signaling complex
TAX1BP1 is pivotal for the termination of NF-kappaB (show NFKB1 Proteins) and JNK (show MAPK8 Proteins) signaling by functioning as an essential regulator of A20 (show TNFAIP3 Proteins).
TAX1BP1 is an essential adaptor for linking A20 (show TNFAIP3 Proteins) to TRAF6 (show TRAF6 Proteins) and other factors in order to influence NF-B activation.
These results reveal the molecular mechanism of TIP-1 as an antagonist in PDZ domain signaling.
Results show that TAX1BP1 translocates to mitochondria in response to RNA virus infection and inducibly interacts with the MAVS (show MAVS Proteins) adaptor protein and indicate that TAX1BP1 functions as an adaptor molecule for Itch to target MAVS (show MAVS Proteins) during RNA virus infection and thus restrict virus-induced apoptosis.
TAX1BP1 downregulation by EBV-miR (show MLXIP Proteins)-BART15-3p enhances chemosensitivity of gastric cancer cells to 5-fluorouracil.
we demonstrate that myosin VI (show MYO6 Proteins) and TAX1BP1 are recruited to ubiquitylated Salmonella and play a key role in xenophagy
A protein construct corresponding to the SKICH domain plus the linker region was expressed, purified and crystallized for TAX1BP1.
RNF11 (show RNF11 Proteins) functions together with TAX1BP1 to restrict antiviral signaling and IFN-beta (show IFNB1 Proteins) production.
Autophagy of Tax1bp1/Ndp52 (show CALCOCO2 Proteins) promotes non-canonical NF-kappaB (show NFKB1 Proteins) signalling.
Allele frequencies of three Alu insertions that are located in MEF2C (show MEF2C Proteins) (two of them) and TAX1BP1 genes significantly differ between cohorts of healthy donors and ALL(acute lymphoblastic leukemia) patients.
In a link with T cell leukemia virus-1-associated myelopathy/tropical spastic paraparesis, an alphabeta T cell receptor recognizes a self peptide from neuronal protein (show LRCH1 Proteins) HuD (show ELAVL4 Proteins) in context of histocompatibility antigen HLA-A2.
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tax1 (human T-cell leukemia virus type I) binding protein 1
, tax1-binding protein 1 homolog B
, Tax1 binding protein 1
, muscle-derived protein 62
, TRAF6-binding protein homolog
, tax1-binding protein 1 homolog
, TRAF6-binding protein
, tax1-binding protein 1
, liver regeneration-related protein 2
, liver regeneration-related protein LRRG004