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anti-Human TIRAP Antibodies:
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Human Polyclonal TIRAP Primary Antibody for WB - ABIN550244
Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003
Show all 2 Pubmed References
Human Polyclonal TIRAP Primary Antibody for IHC (fro), WB - ABIN550303
Vogel, Fitzgerald, Fenton: TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. in Molecular interventions 2004
Show all 2 Pubmed References
Human Polyclonal TIRAP Primary Antibody for IHC, ELISA - ABIN1003283
Janeway, Medzhitov: Innate immune recognition. in Annual review of immunology 2002
Show all 4 Pubmed References
Human Polyclonal TIRAP Primary Antibody for IHC, ELISA - ABIN1003284
ONeill, Fitzgerald, Bowie: The Toll-IL-1 receptor adaptor family grows to five members. in Trends in immunology 2003
Show all 4 Pubmed References
Human Polyclonal TIRAP Primary Antibody for IP, WB - ABIN949800
Nguyen, Kim, Kim, Le, Kim, Kang, Hasegawa, Kanaho, Jou, Lee et al.: Phosphatidylinositol 4-phosphate 5-kinase ? facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein ... in The Journal of biological chemistry 2013
Human Polyclonal TIRAP Primary Antibody for ELISA, WB - ABIN268824
Andreakos, Sacre, Smith, Lundberg, Kiriakidis, Stonehouse, Monaco, Feldmann, Foxwell: Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP. in Blood 2004
Human Polyclonal TIRAP Primary Antibody for ELISA, WB - ABIN251287
Farina, Krumbholz, Giese, Hartmann, Aloisi, Meinl: Preferential expression and function of Toll-like receptor 3 in human astrocytes. in Journal of neuroimmunology 2005
Human Polyclonal TIRAP Primary Antibody for IHC (p), WB - ABIN880289
Rolf, Kariminia, Ivison, Reid, Schultz: Heterodimer-specific TLR2 stimulation results in divergent functional outcomes in B-cell precursor acute lymphoblastic leukemia. in European journal of immunology 2015
Human Polyclonal TIRAP Primary Antibody for IF (p), IHC (p) - ABIN873277
Wang, Schwab, Fan, Seagroves, Buolamwini: Chemoprevention Activity of Dipyridamole in the MMTV-PyMT Transgenic Mouse Model of Breast Cancer. in Cancer prevention research (Philadelphia, Pa.) 2013
Zebrafish Tirap adaptor lacks the phosphatidylinositol 4,5-bisphosphate binding motif, which could partially explain zebrafish insensitivity to lipopolysaccharide, hence its resulting inability to activate downstream Toll (show TLR4 Antibodies)-like receptor signaling.
MAL is not disulfide-bonded and requires glutathionylation of C91 (show CD244 Antibodies) for signaling.
The Mal-Toll (show TLR4 Antibodies)/interleukin-1 receptor (TIR) domains AB loop is capable of mediating direct binding to the TIR domains of TLR4 (show TLR4 Antibodies) and MyD88 (show MYD88 Antibodies) simultaneously.
MAL is multifunctional and integral for the molecular control of bacterial infections as well as inflammatory diseases. [Review]
Data indicate that TcpB (Q8YF5, BtpA/Btp1) interacts with MAL, MyD88 (show MYD88 Antibodies), and TLR4 (show TLR4 Antibodies) but interferes only with the MAL-TLR4 (show TLR4 Antibodies) interaction.
Docking and physicochemical studies indicated that BTK (show BTK Antibodies) was involved in close contact with Tyr86 and Tyr106 of MAL, whereas PKCdelta (show PKCd Antibodies) may phosphorylate Tyr106 only.
Results show that MAL protein binds to and regulates MYD88 (show MYD88 Antibodies).
Here the authors show that MAL TIR domains spontaneously and reversibly form filaments in vitro. They also form cofilaments with TLR4 (show TLR4 Antibodies) TIR domains and induce formation of MyD88 (show MYD88 Antibodies) assemblies.
The major allele A of rs2511521 located in DRD2 (show DRD2 Antibodies) and the minor allele T of rs625413 located in TIRAP are significantly associated with increased risk of food addiction in overweight/obese subjects with low/zero food addiction symptoms.
Combined targeting of UBAP1 (show UBAP1 Antibodies) and toll (show TLR4 Antibodies)-like receptor adaptors TIRAP and MyD88 (show MYD88 Antibodies) by Pseudomonas aeruginosa PumA (show BBC3 Antibodies) impedes both cytokine and toll (show TLR4 Antibodies)-like receptor signalling, highlighting a novel strategy for innate immune evasion.
Epistatic interaction between MyD88 (show MYD88 Antibodies) and TIRAP against Helicobacter pylori.
TIRAP plays a functional role in transducing LPS (show IRF6 Antibodies) signaling from TLR-4 (show TLR4 Antibodies) to downstream effector molecules involved in NF-kappaB (show NFKB1 Antibodies) activation, and TIRAP promotes apoptotic signaling
TIARP (show STEAP4 Antibodies) independently down-regulated CXCL2 (show CXCL2 Antibodies) and IL-6 (show IL6 Antibodies) production by fibroblast-like synoviocytes, and the expression of chemokine (show CCL1 Antibodies) receptors (CXCR1 (show CXCR1 Antibodies) and CXCR2 (show CXCR2 Antibodies)) in neutrophils, with resultant reduction of neutrophil migration into arthritic joints.
Our key findings provide novel insights into the mechanism of action of heterotrimeric complex (PKCdelta (show PKCd Antibodies)-TIRAP-p38 (show CRK Antibodies)) in proinflammatory cytokine expression, which controls the development of the inflammatory trigger in stimulated macrophages.
Results suggest that TIR domain-containing adaptor protein positively regulated BV2 (show DNAH9 Antibodies) microglial M1 polarization through toll-like receptor 4 (show TLR4 Antibodies) -mediated Transforming Growth Factor-Beta-Activated Kinase 1 (show MAP3K7 Antibodies)/I-Kappa-B Kinase /Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells (TAK1 (show NR2C2 Antibodies)/IKK (show CHUK Antibodies)/NF-kappaB (show NFKB1 Antibodies)), mitogen-activated protein kinases and Akt (show AKT1 Antibodies) signalling pathways.
The adapter Mal (encoded by TIRAP) has appeared crucial for the cytokine production by Ly6C(lo) but not by Ly6C(hi) monocytes. The protein Mal was necessary to induce cytokine synthesis by Ly6C(lo) monocytes after triggering TLR2 or TLR9 (show TLR9 Antibodies).
genetic polymorphism is associated with interferon-gamma (show IFNG Antibodies) signaling and susceptibility to infections
TIRAP/Mal deficiency significantly inhibited the activity of titanium particles with adherent bacterial debris to stimulate in vivo osteolysis and in vitro cytokine mRNAs and secretion.
A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis.
The D-helix peptide, 2R9, also potently inhibited TLR4 (show TLR4 Antibodies), TLR7 (show TLR7 Antibodies), and TLR9 (show TLR9 Antibodies), but not TLR3 (show TLR3 Antibodies) or TNF-alpha (show TNF Antibodies) signaling. Cell imaging, co-immunoprecipitation, and in vitro studies demonstrated that 2R9 preferentially targets TIRAP.
MyD88 adaptor (show MYD88 Antibodies)-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C (show PKC Antibodies).
our data reveal a differential, but inflammation-independent, requirement for Mal and MyD88 during TLR2-promoted gastric tumourigenesis.
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants\; however, not all variants have been fully described.
MyD88 adapter-like protein
, Toll-interleukin 1 receptor domain-containing adaptor protein
, toll/interleukin-1 receptor domain-containing adapter protein
, TIR domain-containing adaptor protein
, Toll-like receptor adaptor protein
, adapter protein wyatt
, adaptor protein Wyatt
, toll-interleukin 1 receptor domain-containing adaptor protein
, TIR domain-containing adapter protein
, Toll-like receptor 4 adaptor protein
, myD88 adapter-like protein