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anti-Human TLR10 Antibodies:
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Human Polyclonal TLR10 Primary Antibody for WB - ABIN550247
Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003
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Human Polyclonal TLR10 Primary Antibody for WB - ABIN541223
Janeway, Medzhitov: Innate immune recognition. in Annual review of immunology 2002
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Polyclonal TLR10 Primary Antibody for WB - ABIN540263
Chuang, Ulevitch: Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. in Biochimica et biophysica acta 2001
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Human Polyclonal TLR10 Primary Antibody for ELISA, WB - ABIN1003318
ONeill, Fitzgerald, Bowie: The Toll-IL-1 receptor adaptor family grows to five members. in Trends in immunology 2003
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Human Polyclonal TLR10 Primary Antibody for IHC (p), WB - ABIN259853
Mulla, Myrtolli, Tadesse, Stanwood, Gariepy, Guller, Norwitz, Abrahams: Cutting-edge report: TLR10 plays a role in mediating bacterial peptidoglycan-induced trophoblast apoptosis. in American journal of reproductive immunology (New York, N.Y. : 1989) 2013
phylogenetic analysis of the cytoplasmic regions of TLR genes suggested that the signal transduction pathway of TLR10 was different from those of TLR1 and TLR6
Variants of TLR10 may show an ethnic specificity on susceptibility to TB in Tibetan individuals. rs11466617 affected the susceptibility to progress from LTBI to active TB disease, but was not associated with the establishment of LTBI after M. tuberculosis exposure.
Study findings suggest that TLR1 rs4833095 and TLR10 rs10004195 may play crucial roles in H. pylori susceptibility and gastric pathogenesis in the Thai population.
polymorphism in the TLR10 gene seems to increase the risk of post-bronchiolitis asthma in preschool-aged children
rs4129009 polymorphism increased the risk of persistent asthma continuing from five to seven years of age until 11-13 years of age and increased the risk of needing inhaled corticosteroids at 11-13 years of age
The TLR10 992AA genotype might increase and TLR10 720CC genotype might decrease susceptibility to pathogenesis of Crimean Congo hemorrhagic fever (CCHF) disease. TLR 10 polymorphisms may be also an important biomarker for CCHF susceptibility and fatality rate.
Our results indicate that the presence of TLR10 rs10004195, A/T heterozygous, and T/T homozygous genotypes is associated with type 1, 2, and 3 whereas that of the A/A homozygous genotype is associated with type 4 and 5 of gastric mucosal patterns. This suggests that the A/A homozygous genotype contributes to severe inflammation in H. pylori-associated gastritis in Thai patients.
data show increased TLR10 gene/protein expression in the adipose tissue in obesity/type-2 diabetes (T2D) which relates directly with BMI; data also show that ROS-mediated oxidative stress could induce expression of TLR10 in monocytic cells through the mechanism that involves NF-kappaB and MAPK signaling pathways and the ER stress response
A TLR10 allelic variant, I473T, has impaired NFkB inhibitory activity and is highly associated with disease severity and low response to infliximab in patients with rheumatoid arthritis
The data demonstrate that TLR10 is a novel regulator of innate immune responses and of the differentiation of primary human monocytes into effective dendritic cells.
these results demonstrate that TLR10 functions as a broad negative regulator of TLR signaling
Our results demonstrate that TLR10 has a functional role within the B cell lineage that is distinct from that of other TLR family members
Study concludes that genetic variation in the TLR10-TLR1-TLR6 gene cluster mediates responsiveness to organic dust, but indicates different signaling pathways for IL-6 and TNF-alpha. These studies provide new insight into the role of the TLR10-TLR1-TLR6 gene cluster and the innate immune response to organic dust.
Our results suggest that TLR10 is involved in the recognition of FSL-1, LPS, and flagellin and TLR-ligand-induced expression of TNF-alpha does not depend on TLR10.
Data indicate that polymorphisms in toll like receptor 10 (TLR10) are not associated with chronic Q fever.
Study annotated variants at 4p14 as expression quantitative trait loci (eQTL) associated with TLR6/10 and FAM114A1; findings suggest that 4p14 polymorphisms are linked to host immune response to H. pylori infection but not to its acquisition.
concluded that TLR-1 rs4833095 and TLR10 rs10004195 confer susceptibility to development of gastroduodenal disease, especially GC in H.pylori disease
genetic variants in TLR10 are associated with protection against complicated skin and skin structure infections
TLR1 rs4833095 and TLR10 rs10004195 may play crucial roles in H. pylori susceptibility and gastric pathogenesis.
Our results suggest that TLR10 polymorphisms may contribute to the pathogenesis of autoimmune thyroid diseases.
single nucleotide polymorphism (SNP) in TLR10 (rs11096957) is associated with risk for Tuberculosis
The expression analysis showed similar expression profiles for TLR1 and TLR6, which indicate a co-regulation of these two genes, TLR10 had a different expression profile, pointing toward a stronger functional diversification compared to TLR1 and TLR6.
Prediction and comparison of TLR protein domain architectures for multiple species revealed seven conserved regions of LRR patterning associated with the three genes investigated.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
toll-like receptor 10
, toll-like receptor 10-like