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TLR6 role in Kawasaki disease susceptibility in African American family
The mRNA levels of Toll-like receptors TLR2, 6, and 9 were significantly elevated in the Kawasaki disease (KD) patient group versus the healthy controls.
Significant correlations with atherosclerosis susceptibility were found for the toll like receptor 1 (TLR1 (show TLR1 Proteins)) rs5743551 polymorphism and toll like receptor 6 (TLR6) rs5743810 polymorphism.
Study concludes that genetic variation in the TLR10 (show TLR10 Proteins)-TLR1-TLR6 gene cluster mediates responsiveness to organic dust, but indicates different signaling pathways for IL-6 (show IL6 Proteins) and TNF-alpha (show TNF Proteins). These studies provide new insight into the role of the TLR10 (show TLR10 Proteins)-TLR1-TLR6 gene cluster and the innate immune response to organic dust.
Studied the relationship between polymorphisms in MBL (show MBL2 Proteins), TLR1 (show TLR1 Proteins), TLR2 and TLR6 encoding genes and stimulated IFN-gamma (show IFNG Proteins) and IL-12 (show IL12A Proteins) ex vivo production in BCG (show SLC11A1 Proteins) osteitis survivors. Found that variant genotypes of the MBL2 (show MBL2 Proteins) gene (if homozygous) and variant genotypes of the TLR2 gene (only heterozygotes present) are associated with low IFN-gamma (show IFNG Proteins) production.
efficient method for preparation of the extracellular domain of human Toll-like receptor 6 (TLR6ED) in Escherichia coli using the bubbling cultivation method. Our preparation method improved the level of expression of TLR6ED into a soluble fraction as compared with typical cultivation using a rotary shaker. Circular dichroism (CD) experiments confirmed the structural formation of TLR6ED with secondary structure contents
Toll-like receptor 6 (TLR6) is significantly overexpressed in the hepatocytes of non-alcoholic fatty liver disease (NAFLD patients compared to their normal counterparts.
study demonstrates a significant association between TLR4 (show TLR4 Proteins) rs192791 and TLR6 rs1039559 SNPs and posttransplantation diabetes mellitus in renal transplantation recipients
Study showed that MyD88 Toll/interleukin-1 receptor (TIR) domain interacted with TLR5TIR but not with TLR6TIR. The solubility of both TLR5TIR and TLR6TIR were influenced by its binding partner MyD88TIR.
Study annotated variants at 4p14 as expression quantitative trait loci (eQTL (show EQTN Proteins)) associated with TLR6/10 and FAM114A1 (show FAM114A1 Proteins); findings suggest that 4p14 polymorphisms are linked to host immune response to H. pylori infection but not to its acquisition.
the cooperative role of TLR9 (show TLR9 Proteins) with TLR2 or TLR6 receptors in sensing Brucella, was determined.
Data suggest that the transmembrane domains of Tlr4 (show TLR4 Proteins) and Tlr6 have essential roles in Tlr4 (show TLR4 Proteins)/Tlr6/Cd36 (show CD36 Proteins) receptor multimerization and activation; disruption of receptor multimerization (here, using a recombinant peptide fragment from Tlr4 (show TLR4 Proteins) transmembrane domain) reduces secretion of proinflammatory mediators from microglia and ultimately rescues neurons from death.
TLR6 knockout alleviates generation of myocardial fibrosis by suppressing collagen deposition.
Dengue virus NS1 (show IVNS1ABP Proteins) protein is the viral protein responsible for the activation of TLR2 and TLR6 during Dengue virus infection
Hepatic expression of Tlr6, but not that of Tlr8 (show TLR8 Proteins) is epigenetically controlled, and that the dysregulations of Tlr6 and Tlr8 (show TLR8 Proteins) critically contribute to Testosterone (T)-induced persistent susceptibility to P. chabaudi malaria.
lipopeptides elicit TLR1/2 and TLR2/6 signaling in the endolysosomes, but not on the cell surface.
Transmembrane oligomeric form of Vibrio cholerae cytolysin (show PRF1 Proteins) (VCC) triggers TLR2/TLR6-dependent proinflammatory responses in monocytes and macrophages.
long-term exposure to nicotine up-regulated the expression of TLR4 (show TLR4 Proteins) and -6 via a JNK (show MAPK8 Proteins)-related pathway, causing an exaggeration of the LPS (show TLR4 Proteins)-induced local airway inflammation and increased airway hyperreactivity
The results demonstrate that inflammatory responses caused by ZNPs-activated macrophages strongly depend on TLR6-mediated MAPK (show MAPK1 Proteins) signalling.
aortic angiogenesis is preceded by an immune reaction with overexpression of Toll (show TLR4 Proteins)-like receptors (TLRs) and TLR-inducible genes.
In total, 20, 27, and 26 SNPs were detected in TLR1 (show TLR1 Proteins), TLR2, and TLR6, respectively; SNPs detected in TLR6 may represent species-specific function on the protein level in the wild boars and domestic pigs.
both TLR2 and TLR6 are important in the recognition of M. hyopneumoniae in porcine alveolar macrophages
phylogenetic analysis of the cytoplasmic regions of TLR genes suggested that the signal transduction pathway of TLR10 (show TLR10 Proteins) was different from those of TLR1 (show TLR1 Proteins) and TLR6
Variants in the TLR6 gene are associated with susceptibility to bovine TB.
TLR2, TLR1 (show TLR1 Proteins), and TLR6 haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
The expression analysis showed similar expression profiles for TLR1 (show TLR1 Proteins) and TLR6, which indicate a co-regulation of these two genes, TLR10 (show TLR10 Proteins) had a different expression profile, pointing toward a stronger functional diversification compared to TLR1 (show TLR1 Proteins) and TLR6.
Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 (show PGLYRP1 Proteins) and Toll (show TLR4 Proteins)-like receptors 2 and 6.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.
toll-like receptor 1 type 1
, toll-like receptor 16
, toll-like receptor1