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Data suggest a central role of XBP1 (show XBP1 Proteins) in TLR7-induced IFNalpha production and identify XBP1 (show XBP1 Proteins) as a potential novel therapeutic target in IFNalpha-driven autoimmune and inflammatory diseases.
These findings suggest that increased EV71 and CA16 replication meditated by autophagy in 16HBE cells might promote degradation of the endosome, leading to suppression of the TLR7-mediated IFN-I signaling pathway.
The present study investigated the effects of vitamin D3 on the expression of TLR3 (show TLR3 Proteins), TLR7, and TLR9 (show TLR9 Proteins) in Systemic lupus erythematosus patients.
Data suggest that IRAK4 (show IRAK4 Proteins) activity regulates activation of IRF5 (show IRF5 Proteins), TAK1 (show MAP3K7 Proteins), and IKKB (show IKBKB Proteins) in monocytes; IRAK4 (show IRAK4 Proteins) activation of TAK1 (show MAP3K7 Proteins)-IKKB (show IKBKB Proteins)-IRF5 (show IRF5 Proteins) axis leads to induction of cytokines and interferons following TLR7/TLR8 (show TLR8 Proteins) stimulation. (IRAK4 (show IRAK4 Proteins) = interleukin-1 receptor-associated kinase 4 (show IRAK4 Proteins); IRF5 (show IRF5 Proteins) = interferon regulatory factor-5 (show IRF5 Proteins); TAK1 (show MAP3K7 Proteins) = MAPK (show MAPK1 Proteins) kinase kinase 7; IKKB (show IKBKB Proteins) = I-kappa B kinase; TLR = toll (show TLR4 Proteins)-like receptor)
findings indicate that hepatitis C virus induces CD4 (show CD4 Proteins) T cell impairment via TLR7 which may contribute to failure of virus eradication, casting doubts on the use of TLR7 agonists to boost innate immunity in chronic RNA virus infections.
TLR 5 (show TLR5 Proteins), 7, and 9 expression patterns differed between HPV-positive and -negative oropharyngeal squamous cell carcinoma patients. In HPV-positive tumors the expression of TLR 5 (show TLR5 Proteins) and 7 correlated with tumor recurrence.
Low TLR7 copy number is a risk factor for chronic hepatitis B virus infection but is not associated with later stages of disease progression
TLR7 and TLR8 (show TLR8 Proteins) genetic polymorphisms are associated with susceptibility to mycobacterium tuberculosis infection, and the link is shaped by less effective MTB (show NCAPG2 Proteins) phagocytosis and impaired TLR signaling.
Study evaluated innate immune profiles following TLR stimulation in HIV-1-infected mothers and newborns, found significantly compromised cytokine responses upon extracellular and intracellular TLR activation. Myeloid dendritic cell (DC) responsiveness appeared to be less impaired than plasmacytoid DCs, and might be enhanced through TLR7/TLR8 (show TLR8 Proteins) activation.
This is the first study illustrating certain genotypes of TLR-7 and TLR-8 (show TLR8 Proteins) single nucleotide polymorphisms viz. CT(p = 0.002)]; rs3853839[GC(p < 0.001), CC(p = 0.039)] and rs3764879[GC(p < 0.001)] were considerably associated with Chikungunya virus susceptibility.
Toll-like receptor 2 (TLR2) controls random motility, while Toll-like receptor 7 (TLR7) regulates chemotaxis of microglial cells via distinct pathways. Furthermore, TLR7 mRNA expression is down-regulated by TLR2 and TLR7 activation.
results provide evidence that G, dG, 8-OHG and 8-OHdG are novel endogenous ligands for TLR7.
these data demonstrate that TLR7/TLR9 (show TLR9 Proteins) ligands push the macrophage into a phagocytic long-lived cell, with a decreased capacity of antigen presentation and reminiscent of the M2 polarized state.
Virus infection activates endosomal NOX2 (show CYBB Proteins) oxidase and restricts TLR7 signaling, and that an endosomal NOX2 (show CYBB Proteins) inhibitor decreases viral pathogenicity.
the JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) pathway provides a cytokine rheostat mechanism, which enables macrophages to fine-tune their responses to multiple, temporally separated infection events involving the TLR3 (show TLR3 Proteins) and TLR7 pathways.
TLR7 deficiency attenuates retinal damage in diabetic retinopathy model.
The data demonstrate that an atypical TLR7 signaling pathway contributes to type interferon-beta (show IFNB1 Proteins) expression during Y. pestis infection and suggest that the TLR7-driven type I IFN response plays an important role in determining the outcome of plague.
Evaluation of the adjuvant effect of agonists of toll-like receptor 4 (show TLR4 Proteins) and 7/8 in a vaccine against leishmaniasis
these data demonstrate that extracellular-miRNA mimics (miR (show MLXIP Proteins)-34a, -122, -133a, -142, -146a, and -208a) are potent innate immune activators and that the miRNAs most likely induce cytokine production and leukocyte migration through TLR7 signaling
study demonstrates that activation of TLR7 signaling in T cells can inhibit Th17 cell differentiation from naive T cells and IL-17 (show IL17A Proteins) production in established Th17 cells; further report that downregulation of STAT3 (show STAT3 Proteins) signaling is responsible for TLR7-mediated inhibition of Th17 cells due to induction of suppressor of cytokine signaling 3 (show SOCS3 Proteins) and 5
TLR7 stimulation of Bovine Viral Diarrhea Virus Type 2-infected monocyte-derived macrophages induced cytokine secretion, unlike results observed for other Toll (show TLR4 Proteins)-Like Receptors.
The results from this study demonstrate that expression of at least TLR3 (show TLR3 Proteins), TLR7 and TLR8 (show TLR8 Proteins) is stimulated upon bovine alpha-herpesvirus infection of the brain.
expression of TLR3 (show TLR3 Proteins), TLR7 and TLR9 (show TLR9 Proteins) in alveolar macrophages infected with different genotype 1 PRRSV strains
Porcine TLR7 and TLR8 (show TLR8 Proteins) genes from pig lymph node tissue, were cloned and characterized.
The messenger RNA sequences and exon/intron structures of Toll (show TLR4 Proteins)-like receptors 3, 7, and 8 were determined.
A total of 22 polymorphic sites were observed in TLR7 gene of 24 goats representing 12 different breeds, out of which 19 were present within the coding region and three in 3'UTR.
Activation of Toll-like receptor 7 might prevent development of airway hyperresponsiveness by acting on the airway smooth muscle.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
toll-like receptor 7
, toll-like receptor 7-like
, toll like receptor 7
, toll-like receptor 7-long