Browse our anti-Haptoglobin (HP) Antibodies

Human Haptoglobin (HP) interaction partners

1. identified two proteins, haptoglobin and fibrinogen, as potential biomarker-candidates of fibromyalgia

2. Increased risk of the Hp 1-1/2-1 phenotypes for developing actinic keratoses (AK) compared with Hp 2-2 patients; patients carrying the Hp 1-1 type developed squamous cell carcinoma (SCC) at an earlier age. Hp 1-1 and to a lesser extent Hp 2-1 seems to increase the risk for AK and SCC in sun-exposed areas as compared with the Hp 2-2 phenotype.

3. The rs2000999 polymorphism in the haptoglobin-encoding gene Mexican carriers have increased levels of Low Density Cholesterol and total Cholesterol independently of Type 2 Diabetes diagnosis, and also increased concentrations of High-Density Lipoprotein Cholesterol in the Type 2 Diabetes sample.

4. data lead to the hypothesis that kidney iron deposition is increased among Hp 2-2 carriers with albuminuria in type 1 diabetes

5. Hp 1-1 genotype, which is 2-fold (approximately 30%) more prevalent among African American individuals than among individuals of white race/ethnicity, was associated with poorer cognitive function and greater cognitive decline than the other Hp genotypes.

6. Higher CSF ceruloplasmin, haptoglobin, and VEGF are associated with a significantly greater likelihood of HIV-associated neurocognitive disorders.

7. Circulating Haptoglobin and Metabolic Syndrome in Renal Transplant Recipients

8. A number of blood metabolites, especially phosphatidylcholine and lyso-PCs, were associated with serum Hp levels and blood lipid metabolism by using a targeted metabolomics approach in Chinese T2DM patients and non-DM subjects.

9. The results indicate that Hpt phenotype is a critical for the clinical application of Fuc-Hpt as a cancer biomarker.

10. Low haptoglobin expression is associated with Malaria.

11. Suggest a causal relationship between serum Hp levels and macroangiopathy in Chinese type 2 diabetes patients by Mendelian randomization analysis.

12. findings suggest that rs5471 is a strong genetic determinant of HP levels in Ghanaians, and this seems to be characteristic of Africans

13. We report on the identification of a novel 72 kd Hb reactive species which is cross-linked to HDL and demonstrate that vitamin E in HDL is decreased in Hp 2-2 diabetes mellitus individuals.

14. zonulin appears not to be an inflammatory marker in CKD. It seems it also does not play a role in the disturbances of iron metabolism in CKD. Its physiological role remains to be elucidated.

15. High serum Haptoglobin levels, but not Hp1-Hp2 polymorphism is associated with polycystic ovary syndrome.

16. Hp 2-2 phenotype is an independent predictor of postoperative acute kidney injury and is associated with decreased short and long-term survival after cardiac surgery in patients with diabetes mellitus.

17. Due to its fluctuation, a single measurement of zonulin level is not recommended for assessment of intestinal barrier integrity.

18. Review/Meta-analysis: No association was found between the Hp gene variants and retinopathy in type 2 diabetics.

19. This study investigates the involvement of Hp glycosylation in gastric cancer. It examined the site-specific glycosylation of serum Hp, revealing the feasibility of glycoproteomic profiling as a powerful platform for potential diagnostic markers with high sensitivity and high specificity for gastric cancer.

20. Differentially expressed haptoglobin can serve as a potential biomarker for type 2 diabetic mellitus in the American Hispanic population.

Cow (Bovine) Haptoglobin (HP) interaction partners

1. These results indicate that it is possible to monitor the course of pyometra in cows based on the evaluation of the concentration of cytokines and Hp in the serum and uterine washings.

2. These data demonstrate that serum neutrophil haptoglobin-MMP 9 complexes appear sooner and decline more rapidly than other acute phase proteins.

3. An increase in serum amyloid A or haptoglobin in dairy cows with abomasal displacementis not specific for inflammation or bacterial infection; increased levels of either may indicate the presence of hepatic lipidosis.

4. Haptoglobin concentration may be a useful indicator for cows with postpartum reproductive disorders.

5. Presence in the milk of the acute phase proteins (APP), haptoglobin (Hp) and serum amyloid A to see the relationships in cow composite and bulk tank milk samples.

6. Bovine granulocytes, isolated from peripheral blood of healthy cattle, contain abundant amounts of haptoglobin within the granules.

7. This study suggests that neutrophils and epithelial cells may play an essential role in elevating milk haptoglobin (Hp) in addition to previous suggestions that Hp may be derived from mammary tissues and circulation.

Mouse (Murine) Haptoglobin (HP) interaction partners

1. the levels of trisialylated triantennary glycans of haptoglobin and vitamin D-binding protein increased significantly as liver cancer disease progressed, while the alteration in these protein levels were modest.

2. Both immunoblot analyses and enzymelinked immunosorbent assays confirmed the increased concentration of haptoglobin in crude mdx4cv serum. This suggests that haptoglobin, in conjunction with other altered serum proteins, represents a novel diagnostic, prognostic and/or therapymonitoring biomarker candidate to evaluate the inflammatory response in the mdx4cv animal model of dystrophinopathy.

3. Data show that zonulin-dependent small intestinal barrier impairment is an early step leading to the break of tolerance with subsequent development of chronic inflammatory diseases (CIDs).

4. the interaction between haptoglobin genotype and vitamin E affects atherosclerotic plaque progression and stability

5. Exogenous haptoglobin attenuated the HbA-induced HO-1 expression in vitro and in mouse model of sickle cell disease.

6. Suggest haptoglobin is an enhancer of inflammation after cardiac transplantation, contributing to graft rejection.

7. Zonulin facilitates development of acute lung injury (ALI) both by enhancing albumin leak and complement activation as well as increased buildup of neutrophils and cytokines during development of ALI.

8. Haptoglobin deficiency is associated with leakage-prone vessels via isolated VEGFA induction and/or suppressed Ang-1 expression, resulting in unbalanced VEGFalpha/Ang-1 transcription.

9. Hp generated by the B-cell compartment, rather than by the liver, is functionally contributing to a normal immune response.

10. the Hp2-2 protein is involved in aneurysm formation and that the Hp genotype may be a useful biomarker in predicting aneurysm progression

11. Experimental models of colitis showed that haptoglobin has a protective role in inflammatory colitis

12. these studies provide direct evidence that the increased oxidative stress in Hp 2-2 atherosclerotic plaques is due to hemoglobin derived iron.

13. Synthetic PPAR gamma ligands selectively activate PPAR gamma bound to the haptoglobin gene promoter to arrest haptoglobin gene transcription.

14. Hp may be regarded as a regulator of the Th1/Th2 balance in both human and murine immune systems.

15. Hp plays a pivotal role in reducing renal oxidative damage during haemolysis.

16. Haptoglobin gene expression regulation

17. haptoglobin and hemopexin together are essential for protection from splenomegaly and liver fibrosis resulting from intravascular hemolysis

18. the haptoglobin gene expression in adipocytes is stimulated by inflammatory cytokines, glucocorticoids, and the sympathetic system

19. haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in hemochromatosis

20. a direct linkage between diabetic vascular disease and the Hp genotype.

Pig (Porcine) Haptoglobin (HP) interaction partners

1. crystal structure of the dimeric porcine haptoglobin-haemoglobin complex determined at 2.9 A resolution

2. This protein is elevated in porcine postweaning multisystemic wasting syndrome.

3. haptoglobin has a role in oxidative status in piglets undergoing weaning-induced stress

4. This study suggested closer links between the release of haptoglobin, Pig-MAP and monocytes compared to the release of AGP, SAA and transthyretin.

5. The haptoglobin was down-regulated with SNPs

6. Presence of haptoglobin alpha 1S subunit is a reponse to respiratory syndrome virus infection.

Horse (Equine) Haptoglobin (HP) interaction partners

1. results highlight the potential usefulness of Hp as inflammatory marker in horses, showing for the first time the increase of Hp in SF from joint inflammation in the horse

2. Surfactant protein D and haptoglobin serum concentrations could be a diagnostic aid for equine inflammatory airway disease.