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identified two proteins, haptoglobin and fibrinogen, as potential biomarker-candidates of fibromyalgia
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Increased risk of the Hp 1-1/2-1 phenotypes for developing actinic keratoses (AK) compared with Hp 2-2 patients; patients carrying the Hp 1-1 type developed squamous cell carcinoma (SCC) at an earlier age. Hp 1-1 and to a lesser extent Hp 2-1 seems to increase the risk for AK and SCC in sun-exposed areas as compared with the Hp 2-2 phenotype.
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The rs2000999 polymorphism in the haptoglobin-encoding gene Mexican carriers have increased levels of Low Density Cholesterol and total Cholesterol independently of Type 2 Diabetes diagnosis, and also increased concentrations of High-Density Lipoprotein Cholesterol in the Type 2 Diabetes sample.
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data lead to the hypothesis that kidney iron deposition is increased among Hp 2-2 carriers with albuminuria in type 1 diabetes
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Hp 1-1 genotype, which is 2-fold (approximately 30%) more prevalent among African American individuals than among individuals of white race/ethnicity, was associated with poorer cognitive function and greater cognitive decline than the other Hp genotypes.
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Higher CSF ceruloplasmin, haptoglobin, and VEGF are associated with a significantly greater likelihood of HIV-associated neurocognitive disorders.
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Circulating Haptoglobin and Metabolic Syndrome in Renal Transplant Recipients
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A number of blood metabolites, especially phosphatidylcholine and lyso-PCs, were associated with serum Hp levels and blood lipid metabolism by using a targeted metabolomics approach in Chinese T2DM patients and non-DM subjects.
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The results indicate that Hpt phenotype is a critical for the clinical application of Fuc-Hpt as a cancer biomarker.
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Low haptoglobin expression is associated with Malaria.
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Suggest a causal relationship between serum Hp levels and macroangiopathy in Chinese type 2 diabetes patients by Mendelian randomization analysis.
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findings suggest that rs5471 is a strong genetic determinant of HP levels in Ghanaians, and this seems to be characteristic of Africans
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We report on the identification of a novel 72 kd Hb reactive species which is cross-linked to HDL and demonstrate that vitamin E in HDL is decreased in Hp 2-2 diabetes mellitus individuals.
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zonulin appears not to be an inflammatory marker in CKD. It seems it also does not play a role in the disturbances of iron metabolism in CKD. Its physiological role remains to be elucidated.
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High serum Haptoglobin levels, but not Hp1-Hp2 polymorphism is associated with polycystic ovary syndrome.
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Hp 2-2 phenotype is an independent predictor of postoperative acute kidney injury and is associated with decreased short and long-term survival after cardiac surgery in patients with diabetes mellitus.
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Due to its fluctuation, a single measurement of zonulin level is not recommended for assessment of intestinal barrier integrity.
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Review/Meta-analysis: No association was found between the Hp gene variants and retinopathy in type 2 diabetics.
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This study investigates the involvement of Hp glycosylation in gastric cancer. It examined the site-specific glycosylation of serum Hp, revealing the feasibility of glycoproteomic profiling as a powerful platform for potential diagnostic markers with high sensitivity and high specificity for gastric cancer.
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Differentially expressed haptoglobin can serve as a potential biomarker for type 2 diabetic mellitus in the American Hispanic population.