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The purpose of this study was to evaluate the effects of cyclic tensile load on the expression and activity of HYAL in synovial membrane cells.
an important role for HYAL2 in CD44 alternative splicing.
genetic variation in HYAL2 influences platelet aggregation
Knocking down HYAL2 in HUVECs protected against HA degradation in the glycocalyx by inhibiting the expression and activity of HYAL2 and further blocked the dephosphorylation of eNOS-Ser-633 and the decrease in NO production in response to LSS.
HYAL2 mutations identified as a cause of syndromic orofacial clefting and cor triatriatum sinister in amish families.
our data uncover a previously unsuspected mechanism of how hyaluronan and Hyal-2 control platelet generation.
Data show that DNA methylation at CpG island of hyaluronoglucosaminidase 2 (HYLA2) could be used to identify stage II and III colon cancer patients who are most likely to benefit from 5-flourouracil chemotherapy with respect to progression-free survival.
CD44 knock-down in bovine and human chondrocytes results in release of bound HYAL2.
High expression of S100P and HYAL2 is significantly associated with advanced disease and shorter survival of triple-negative breast cancer and S100P and HYAL2 could be potential prognostic markers of TNBC.
HYAL2 plays a redundant role in the catalysis of megadalton HA to its 20 kDa intermediate during fertilization.
Lower platelet HYAL2 levels and activity are associated with inflammatory bowel disease.
A strong association between decreased HYAL2 methylation in peripheral blood and BC.
Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.
HAS2-HYAL2/CD44 system may support spontaneous chemokinesis of human cancer cells through self-degradation of HMW-HA to produce LMW-HA by an autocrine mechanism.
Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma
Overexpression of HYAL2 is associated with colorectal cancer.
ROS induce Hyal2, suggesting that Hyal2 is likely responsible for the sustained HA fragmentation in the airway lumen observed in inflammatory conditions associated with oxidative stress.
Data show that a significant in expression levels of HA synthases (HASs) and hyaluronidases (Hyals) was observed in vitro on stimulation of epithelial ovarian carcinoma cells by gonadotropins.
more elevated in human brain metastases than in primary brain tumours
suppresses transformation by the Env proteins of jaagsiekte sheep retrovirus and enzootic nasal tumor virus in rodent fibroblasts by increasing Env degradation
Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus.
Knockdown of Hyal2 in articular cartilage induced osteoarthritis development and progression possibly mediated by an imbalance of hyaluronan metabolism.
Hyal2(-/-) mice have increased hyaluronan, which may promote endothelial-to-mesenchymal transition and proliferation of mesenchymal cells leading to congenital heart defects and heart failure.
It was concluded that: HYAL1 and HYAL2 are both needed for tissue HA catabolism; 2) HYAL2 is required for high MW HA clearance in lymph nodes and plasma and for HA endocytosis by liver NPCs; and 3) the main role of HYAL1 is HA degradation within liver NPCs.
Hyal2-/- mice present craniofacial abnormalities, including submucosal cleft palate and incompletely penetrant cor triatriatum sinister with hearing loss.
Removal of Hyal2 activity resulted in increased levels of hyaluronan creating a risk for cor triatriatum sinister.
hyaluronidase 2 deficiency induces chronic thrombotic microangiopathy with hemolytic anemia in mice.
HYAL1 is necessary for the breakdown of intracellular HA in the cortex, whereas HYAL2 is essential for the degradation of extracellular HA in all kidney regions
Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction
Hyal-2 enhancement of tumor necrosis factor-alpha-stimulated cytotoxicity in fibroblasts is blocked by Transforming growth factor-beta1.
Hyaluronidase induces ovarian granulosa cell apoptosis and is involved in follicular atresia.
murine HYAL2 has a physiological activity in vivo that is relevant for craniovertebral bone formation, maintenance of plasma hyaluronan concentrations, and erythrocyte and platelet homeostasis.
platelets and megakaryocytes contain only hyaluronidase 2 (HYAL2) but not HYAL1
HYAL2 expression improves the blastocyst rate and embryo quality, an effect which requires CD44 activity and MAPK signaling.
May degrade hyaluronan by analogy to human HYAL2, which is a weak acid-active hyaluronidase. Serves as an entry receptor for jaagsiekte sheep retrovirus in sheep and bovine as well as for enzootic nasal tumor virus in sheep.
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
hyaluronidase 2 b
, hyaluronoglucosaminidase 2
, hyaluronidase 2
, hyaluronidase 2 a
, PH-20 homolog
, PH20 homolog
, lung carcinoma protein 2
, lysosomal hyaluronidase
, GPI-anchored surface protein
, JSRV envelope protein receptor