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high fat diet (HFD) and zinc deficiency synergistically induce obesity-related cardiac hypertrophy (ORCH), by increasing oxidative stress-mediated activation of BCL10 (show BCL10 Proteins)/CARD9 (show CARD9 Proteins)/p38 MAPK (show MAPK14 Proteins) signalling. Zinc supplement ameliorates ORCH through activation of metallothionein (show MT Proteins) to repress oxidative stress-activated BCL10 (show BCL10 Proteins) expression and p38 MAPK (show MAPK14 Proteins) activation.
these results demonstrate that MT1 plays a role in CD4 (show CD4 Proteins)+ T cell activation by transducing reactive oxygen species signals into an increased [Zn2+]i that subsequently affects downstream effector function
Cardioprotective effects of MT1/2 seem to be exerted via modulation of contractile elements, antioxidative enzymes, inflammatory response, and myocardial remodeling.
MT-1(/2) protein levels were dramatically increased by Mt1 overexpression throughout the cortex (Cx), which showed a prominent caudal-rostral gradient, and the hippocampus (HC).
These results suggested that both melatonin and MT1 are involved in the downstream reaction of hCG (show CGA Proteins) (LH) and they play important roles in luteinization.
Metallothionein (show MT Proteins) differentially affects the host response to Listeria infection both with and without an additional stress from cold-restraint
MT overexpression protected beta-cells from acute STZ-induced ROS (show ROS1 Proteins) damages at young age, whereas it impaired insulin (show INS Proteins) secretion and promoted the development of diabetes in adult C57BL/6J mice
Enhanced senescence due to absence of metallothionein (show MT Proteins) genes may shorten lifespan.
MT1/2 deficiency aggravated depleted uruanium-induced nephrotoxicity, and the molecular mechanisms appeared to be related to the increased oxidative stress and apoptosis, and decreased SGLT expression.
Zinc-binding MT1 and MT2 are key modulators of Fc epsilonRI-induced basophil production of IL-4 (show IL4 Proteins).
may play a role in protecting the ovarian tissues from oxidative stress
, metallothionein 1
, metallothionein I
, metallothionein 1A (functional)
, metallothionein 1E (functional)
, metallothionein 1F
, metallothionein 1X