Browse our NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) Proteins (NFS1)

Full name:: NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) Proteins (NFS1)

On www.antibodies-online.com are 4 NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) (NFS1) Proteins from 3 different suppliers available. Additionally we are shipping NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) Antibodies (46) and NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) Kits (3) and many more products for this protein. A total of 57 NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) products are currently listed.

Synonyms:: AA987187, AO090020000619, ARABIDOPSIS THALIANA NITROGEN FIXATION S (NIFS)-LIKE 1, ATCPNIFS, ATNFS1, ATNFS2, ATNIFS1, ATSUFS, chloroplastic NIFS-like cysteine desulfurase, CYSTEINE DESULFURASE, IscS, m-Nfs1, m-Nfsl, MPA24.7, MPA24_7, NFS1, Nifs, NIFS1, nitrogen fixation S (NIFS)-like 1, NITROGEN FIXATION S HOMOLOG 1, SUFS, T27G7.17, T27G7_17

list all proteins	Gene Name	GeneID	UniProt
	NFS1	9054	Q9Y697
Rat NFS1	NFS1	84594
	NFS1	18041
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NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) Proteins (NFS1) by Origin

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Relevant Pathways for NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) Proteins

Transition Metal Ion Homeostasis

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More Proteins for NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) Interaction Partners

Arabidopsis thaliana NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) (NFS1) interaction partners

AtFH binds and modulates Nfs1 kinetics in mitochondria.
NFS1 has a role in mediating the assembly of iron-sulfur clusters in mitochondria.
CpNifS was sufficient for Fe-S cluster formation in ferredoxin in the presence of cysteine and a ferrous iron salt. [CpNifS]
overexpression of this plant NifS-like protein had a pronounced effect on plant Se metabolism
CpNifS is necessary for the maturation of all plastidic Fe-S proteins and, thus, essential for plant growth

Human NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) (NFS1) interaction partners

NFS1 maintains the iron sulfur clusters in proteins that are essential for protecting them from oxidative damage; inactivating NFS1 or iron sulfur clusters can trigger ferroptosis, a non-apoptotic form of cell death, in cancer cells
human NFS1 was almost fully able to complement the role of IscS in Moco biosynthesis when its specific interaction partner protein MOCS3 (show MOCS3 Proteins) from humans was also present.
The NFS1/ISD11 (show LYRM4 Proteins) complex further interacts with scaffold protein (show HOMER1 Proteins) ISCU (show ISCU Proteins) and regulator protein frataxin (show FXN Proteins), thereby forming a quaternary complex for Fe-S cluster formation.
FDX1 (show FDX1 Proteins) and FDX2 (show FDX1L Proteins) both bind NFS1 and donate electrons for iron-sulfur cluster biosynthesis.
Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN (show FXN Proteins)(42-210)]24.[NFS1]24.[ISD11 (show LYRM4 Proteins)]24.[ISCU (show ISCU Proteins)]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components.
Our findings highlight that the ISD11 (show LYRM4 Proteins) R68A/R68L mutation display reduced affinity to form a stable subcomplex with NFS1, and thereby fails to prevent NFS1 aggregation resulting in impairment of the Fe-S cluster biogenesis
The data presented here show that the Isu1 suppressor mimics the frataxin (show FXN Proteins) effects on Nfs1, explaining the bypassing activity.
NFS1 binds preferentially to the D-state of ISCU (show ISCU Proteins) while mtHSP70 (show HSPA9 Proteins) binds preferentially to the D-state of ISCU (show ISCU Proteins) and HSC20 (show HSCB Proteins) binds preferentially to the S-state of ISCU (show ISCU Proteins).
the interaction of NFS1 and MOCS3 (show MOCS3 Proteins) in the cytosol of human cells, is reported.
Nfs1, the cysteine desulfurase responsible for providing sulfur for cluster formation, is required for the increased Isu stability occurring after disruption of cluster formation on or transfer from Isu

Mouse (Murine) NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) (NFS1) interaction partners

NFS1 maintains the iron sulfur clusters in proteins that are essential for protecting them from oxidative damage; inactivating NFS1 or iron sulfur clusters can trigger ferroptosis, a non-apoptotic form of cell death, in cancer cells
there is a mechanism that primarily dedicates m-Nfs1 to the biogenesis of mitochondrial Fe-S clusters in order to maintain cell survival
While IFN-gamma (show IFNG Proteins) alone induced Nfs1 protein instability, LPS (show TLR4 Proteins) triggered a delayed decline of Nfs1, rather involving transcriptional events or mRNA instability.

NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) (NFS1) Protein Profile

Protein Summary

Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae) (NFS1)

nitrogen fixation S (NIFS)-like 1 (NFS1)
chloroplastic NIFS-like cysteine desulfurase (CPNIFS)
aminotransferase family protein (LolT) (AOR_1_546014)
cysteine desulfurase (AOR_1_1076084)
cysteine desulfurase, (m-Nfs1) (trd_A0109)
cysteine desulfurase (Arnit_0871)
cysteine desulfurase (Fbal_3329)
NFS1, cysteine desulfurase (NFS1)
NFS1 cysteine desulfurase (Nfs1)
nitrogen fixation gene 1 (S. cerevisiae) (Nfs1)

AA987187 protein
AO090020000619 protein
ARABIDOPSIS THALIANA NITROGEN FIXATION S (NIFS)-LIKE 1 protein
ATCPNIFS protein
ATNFS1 protein
ATNFS2 protein
ATNIFS1 protein
ATSUFS protein
chloroplastic NIFS-like cysteine desulfurase protein
CYSTEINE DESULFURASE protein
IscS protein
m-Nfs1 protein
m-Nfsl protein
MPA24.7 protein
MPA24_7 protein
NFS1 protein
Nifs protein
NIFS1 protein
nitrogen fixation S (NIFS)-like 1 protein
NITROGEN FIXATION S HOMOLOG 1 protein
SUFS protein
T27G7.17 protein
T27G7_17 protein

Protein level used designations for NFS1

cysteine desulfurase NFS1 , cysteine desulfurase, (m-Nfs1) , cysteine desulfurase , NFS1 nitrogen fixation 1 homolog (S. cerevisiae) , NFS1 nitrogen fixation 1 homolog , cysteine desulfurase, mitochondrial , nitrogen fixation 1 (S. cerevisiae, homolog) , nitrogen-fixing bacteria S-like protein , nitrogen fixation gene 1 , nifS-like (sic) , nitrogen fixation gene, yeast homolog 1

GENE ID	SPECIES
836701	Arabidopsis thaliana
837370	Arabidopsis thaliana
5993796	Aspergillus oryzae RIB40
5996993	Aspergillus oryzae RIB40
7357041	Thermomicrobium roseum DSM 5159
9171028	Arcobacter nitrofigilis DSM 7299
9772182	Ferrimonas balearica DSM 9799
477214	Canis lupus familiaris
704077	Macaca mulatta
745823	Pan troglodytes
100054930	Equus caballus
100408381	Callithrix jacchus
9054	Homo sapiens
419133	Gallus gallus
517656	Bos taurus
100328709	Oryctolagus cuniculus
84594	Rattus norvegicus
100174307	Pongo abelii
18041	Mus musculus

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