Browse our anti-Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) Antibodies

Human Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

1. In this study, we identified three domestic sporadic families of hereditary hemochromatosis (show HFE Antibodies) in China and demonstrated mutations in HFE (show HFE Antibodies) and SLC40A1 respectively.

2. The 1st 3D model of human ferroportin was used to study disease-associated mutations to determine the role of conserved residues in protein stability and iron transport. Molecular mechanisms critical for ferroportin endocytosis include at least 3 fundamental steps: hepcidin (show HAMP Antibodies) binding, structural reorganization of the N- and C-ter (show TECR Antibodies) ferroportin lobes, and ferroportin ubiquitination.

3. SLC40A1 mutation analysis in 7 Italian families with type 4 hereditary hemochromatosis (show HFE Antibodies)

4. Ferroportin protects erythrocytes against oxidative stress and malaria infection.

5. Nrf2 (show GABPA Antibodies) suppresses prostate cancer cells viability, migration, and mitosis by upregulating ferroportin expression.

6. Of the non-HFE (show HFE Antibodies) forms of iron overload, TFR2 (show TFR2 Antibodies)-, HFE2 (show HFE2 Antibodies)-, and HAMP (show HAMP Antibodies)-related forms are predicted to be rare, with pathogenic allele frequencies in the range of 0.00007 to 0.0005. Significantly, SLC40A1 variants that have been previously associated with autosomal-dominant ferroportin disease were identified in several populations (pathogenic allele frequency 0.0004), being most prevalent among Africans

7. study followed the dynamics of hepcidin (show HAMP Antibodies)-mediated ferroportin internalization; also showed that the novel p.D84E mutation, associated with the classical form of ferroportin disease, is both iron transport defective and hepcidin (show HAMP Antibodies) insensitive

8. Reduced expression of ferroportin mRNA identifies a subset of infertile women and may constitute a target for therapy.

9. FPN1 cycles as a monomer within the endocytic/plasma membrane compartment and responds to its physiological inhibitor, Hepc (show HAMP Antibodies), in both control and ferroportin disease (FD) cells. However, in FD, FPN1 fails to reach the cell surface when cells undergo high iron turnover.

10. These results suggest that FPN1 exports iron received from the iron chaperone PCBP2 (show PCBP2 Antibodies). Therefore, it was found that PCBP2 (show PCBP2 Antibodies) modulates cellular iron export, which is an important physiological process.

Zebrafish Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

1. Functional impact of mammalian ferroportin mutations studied in zebrafish.

Cow (Bovine) Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

1. HEP/FPN axis seems to have a central role in infections, with microorganisms within macrophages or that survive in the bloodstream or other cellular spaces. FPN may also have a significant role for embryonic development, growth and organogenesis.

Mouse (Murine) Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

1. Pulmonary iron overload is associated with oxidative stress, restrictive lung disease with decreased total lung capacity and reduced blood oxygen saturation in homozygous Slc40a1(C326S/C326S) mice compared to wild-type controls.

2. ferroportin mRNA downregulation depends on M2 subtype polarization of macrophage

3. Fasting upregulates Fpn1 expression in spleen and peritoneal macrophages, probably via a ghrelin (show GHRL Antibodies)/GHSR1a/MAPK (show MAPK1 Antibodies) signaling pathway.

4. Expression of Hepcidin (show HAMP Antibodies) and Ferroportin in the Placenta, and Ferritin (show FTL Antibodies) and Transferrin Receptor 1 (show TFR Antibodies) Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes

5. findings show that ferroportin expression by macrophages at the site of injury represents a requirement for appropriate activation of myogenic precursors and eventual healing of injured skeletal muscle

6. The results suggest that physiologic hepcidin (show HAMP Antibodies) levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells.

7. In Angiotensin II treated mice, duodenal divalent metal transporter-1 (show SLC11A2 Antibodies) and ferroportin expression levels were increased and hepatic hepcidin (show HAMP Antibodies) mRNA expression and serum hepcidin (show HAMP Antibodies) concentration were reduced.

8. Mice infected with Salmonella typhimurium have increased duodenal expression of the iron exporter ferroportin-1, consistent with increased uptake of dietary iron.

9. Results suggest that reduction in ferroportin levels in Alzheimer's disease brains are likely associated with cerebral ischaemia, inflammation, loss of neurons due to protein misfolding, senile plaque formation and possibly ageing process itself

10. Oral iron failed to be utilized by Fpn-KO mice and was retained in enterocytes, irrespective of the iron source. Ferroportin-dependent efflux from enterocytes controls duodenal iron absorption.

Arabidopsis thaliana Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

1. Data suggest that NRAMP1 (show SLC11A1 Antibodies) plays a pivotal role in Fe transport by cooperating with IRT1 (show PARP3 Antibodies) to take up Fe in roots under replete conditions.

2. role of ABCG37, IRT1 and FRO2 in root Fe2+ transport systems

3. role of IRT1 (show PARP3 Antibodies) in iron uptake

4. Our results reveal a role of SNX1 (show SNX1 Antibodies) for the correct trafficking of IRT1 (show PARP3 Antibodies) and, thus, for modulating the activity of the iron uptake machinery

5. This work establishes a functional link between the dynamics and the lateral polarity of IRT1 (show PARP3 Antibodies) and the transport of its substrates, and identifies a molecular mechanism driving polar localization of a cell surface protein (show CD28 Antibodies) in plants.

6. IDF1 directly regulates IRT1 (show PARP3 Antibodies) degradation through its RING-type E3 ligase activity.

7. Data indicate that steady-state mRNA abundance for three representative Fe homeostasis genes, IRT1 (show PARP3 Antibodies), bHLH39, and FER1 (show FTH1 Antibodies), oscillated in light/dark (LD) cycles or warm/cold environmental cycles.

8. AtIRT1 transports nicekl (Ni(2 (show VMP1 Antibodies)+)) in roots, and strongly suggest that Ni accumulation is further accelerated by AtIRT1 that is expressed in response to excess Ni.

9. These data suggest a model in which monoubiquitin-dependent internalization/sorting and turnover keep the plasma membrane pool of IRT1 (show PARP3 Antibodies) low to ensure proper iron uptake and to prevent metal toxicity.

10. IRT1 and FRO2 genes are upregulated under iron starvation.