Browse our anti-Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) Antibodies

Full name:: anti-Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Antibodies (SLC40A1)

On www.antibodies-online.com are 110 Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) Antibodies from 17 different suppliers available. Additionally we are shipping Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Kits (53) and Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Proteins (8) and many more products for this protein. A total of 178 Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 products are currently listed.

Synonyms:: Dusg, Fpn1, HFE4, IREG1, MGC82700, MST079, MTP, MTP1, Ol5, Pcm, Slc11a3, Slc39a1, SLC40A1, weh

list all antibodies	Gene Name	GeneID	UniProt
	SLC40A1	30061	Q9NP59
	SLC40A1	170840	Q923U9
	SLC40A1	53945	Q9JHI9
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Top referenced anti-Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Antibodies

Human Polyclonal SLC40A1 Primary Antibody for ICC, FACS - ABIN439384 : Vanoaica, Darshan, Richman, Schümann, Kühn: Intestinal ferritin H is required for an accurate control of iron absorption. in Cell metabolism 2010 (PubMed)
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Human Polyclonal SLC40A1 Primary Antibody for IF (p), IHC (p) - ABIN1387819 : Rychtarcikova, Lettlova, Tomkova, Korenkova, Langerova, Simonova, Zjablovskaja, Alberich-Jorda, Neuzil, Truksa: Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism. in Oncotarget 2016 (PubMed)
Show all 2 Pubmed References
Human Polyclonal SLC40A1 Primary Antibody for FACS - ABIN4311374 : Marques, Porto, Rêma, Faria, Cruz Paula, Gomez-Lazaro, Silva, Martins da Silva, Lopes: Local iron homeostasis in the breast ductal carcinoma microenvironment. in BMC cancer 2016 (PubMed)
Human Polyclonal SLC40A1 Primary Antibody for ELISA, WB - ABIN4311379 : Qiao, Sugianto, Fung, Del-Castillo-Rueda, Moran-Jimenez, Ganz, Nemeth: Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. in Cell metabolism 2012 (PubMed)

More Antibodies against Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Interaction Partners

Human Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

In this study, we identified three domestic sporadic families of hereditary hemochromatosis (show HFE Antibodies) in China and demonstrated mutations in HFE (show HFE Antibodies) and SLC40A1 respectively.
The 1st 3D model of human ferroportin was used to study disease-associated mutations to determine the role of conserved residues in protein stability and iron transport. Molecular mechanisms critical for ferroportin endocytosis include at least 3 fundamental steps: hepcidin (show HAMP Antibodies) binding, structural reorganization of the N- and C-ter (show TECR Antibodies) ferroportin lobes, and ferroportin ubiquitination.
SLC40A1 mutation analysis in 7 Italian families with type 4 hereditary hemochromatosis (show HFE Antibodies)
Ferroportin protects erythrocytes against oxidative stress and malaria infection.
Nrf2 (show GABPA Antibodies) suppresses prostate cancer cells viability, migration, and mitosis by upregulating ferroportin expression.
Of the non-HFE (show HFE Antibodies) forms of iron overload, TFR2 (show TFR2 Antibodies)-, HFE2 (show HFE2 Antibodies)-, and HAMP (show HAMP Antibodies)-related forms are predicted to be rare, with pathogenic allele frequencies in the range of 0.00007 to 0.0005. Significantly, SLC40A1 variants that have been previously associated with autosomal-dominant ferroportin disease were identified in several populations (pathogenic allele frequency 0.0004), being most prevalent among Africans
study followed the dynamics of hepcidin (show HAMP Antibodies)-mediated ferroportin internalization; also showed that the novel p.D84E mutation, associated with the classical form of ferroportin disease, is both iron transport defective and hepcidin (show HAMP Antibodies) insensitive
Reduced expression of ferroportin mRNA identifies a subset of infertile women and may constitute a target for therapy.
FPN1 cycles as a monomer within the endocytic/plasma membrane compartment and responds to its physiological inhibitor, Hepc (show HAMP Antibodies), in both control and ferroportin disease (FD) cells. However, in FD, FPN1 fails to reach the cell surface when cells undergo high iron turnover.
These results suggest that FPN1 exports iron received from the iron chaperone PCBP2 (show PCBP2 Antibodies). Therefore, it was found that PCBP2 (show PCBP2 Antibodies) modulates cellular iron export, which is an important physiological process.

Zebrafish Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

Functional impact of mammalian ferroportin mutations studied in zebrafish.

Cow (Bovine) Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

HEP/FPN axis seems to have a central role in infections, with microorganisms within macrophages or that survive in the bloodstream or other cellular spaces. FPN may also have a significant role for embryonic development, growth and organogenesis.

Mouse (Murine) Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

Pulmonary iron overload is associated with oxidative stress, restrictive lung disease with decreased total lung capacity and reduced blood oxygen saturation in homozygous Slc40a1(C326S/C326S) mice compared to wild-type controls.
ferroportin mRNA downregulation depends on M2 subtype polarization of macrophage
Fasting upregulates Fpn1 expression in spleen and peritoneal macrophages, probably via a ghrelin (show GHRL Antibodies)/GHSR1a/MAPK (show MAPK1 Antibodies) signaling pathway.
Expression of Hepcidin (show HAMP Antibodies) and Ferroportin in the Placenta, and Ferritin (show FTL Antibodies) and Transferrin Receptor 1 (show TFR Antibodies) Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes
findings show that ferroportin expression by macrophages at the site of injury represents a requirement for appropriate activation of myogenic precursors and eventual healing of injured skeletal muscle
The results suggest that physiologic hepcidin (show HAMP Antibodies) levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells.
In Angiotensin II treated mice, duodenal divalent metal transporter-1 (show SLC11A2 Antibodies) and ferroportin expression levels were increased and hepatic hepcidin (show HAMP Antibodies) mRNA expression and serum hepcidin (show HAMP Antibodies) concentration were reduced.
Mice infected with Salmonella typhimurium have increased duodenal expression of the iron exporter ferroportin-1, consistent with increased uptake of dietary iron.
Results suggest that reduction in ferroportin levels in Alzheimer's disease brains are likely associated with cerebral ischaemia, inflammation, loss of neurons due to protein misfolding, senile plaque formation and possibly ageing process itself
Oral iron failed to be utilized by Fpn-KO mice and was retained in enterocytes, irrespective of the iron source. Ferroportin-dependent efflux from enterocytes controls duodenal iron absorption.

Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) Antigen Profile

Antigen Summary

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).

Alternative names and synonyms associated with Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1)

solute carrier family 40 member 1 (SLC40A1) antibody
solute carrier family 40 (iron-regulated transporter), member 1 (slc40a1) antibody
solute carrier family 40 (iron-regulated transporter), member 1 S homeolog (slc40a1.S) antibody
solute carrier family 40 member 1 (Slc40a1) antibody
solute carrier family 40 (iron-regulated transporter), member 1 (SLC40A1) antibody
solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1) antibody

Dusg antibody
Fpn1 antibody
HFE4 antibody
IREG1 antibody
MGC82700 antibody
MST079 antibody
MTP antibody
MTP1 antibody
Ol5 antibody
Pcm antibody
Slc11a3 antibody
Slc39a1 antibody
SLC40A1 antibody
weh antibody

Protein level used designations for SLC40A1

, , , , , , , , , , , , , , , , , , , , iron regulated gene 1 putative ferroportin 1 variant IIIB solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 solute carrier family 40 member 1 ferroportin-1 ferroportin1 iron-regulated transporter solute carrier family 39 (iron-regulated transporter), member 1 weissherbst solute carrier family 40 (iron-regulated transporter), member 1 ferroportin CAR1 cell adhesion regulator ferroportin 1 solute carrier family 40 member 1-like SLC11A3 iron transporter duodenal-specific iron-regulated transporter 1 metal transporter protein 1 metal transporting protein 1 polycythaemia

GENE ID	SPECIES
30061	Homo sapiens
58153	Danio rerio
423984	Gallus gallus
446661	Xenopus laevis
459821	Pan troglodytes
478837	Canis lupus familiaris
527023	Bos taurus
713321	Macaca mulatta
100036732	Xenopus (Silurana) tropicalis
100172551	Pongo abelii
170840	Rattus norvegicus
100028485	Monodelphis domestica
100069190	Equus caballus
100474381	Ailuropoda melanoleuca
100512076	Sus scrofa
100588979	Nomascus leucogenys
53945	Mus musculus

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Show all anti-Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) Antibodies with Pubmed References