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Human Polyclonal VPS45 Primary Antibody for WB - ABIN1742303
Waugh, Chu, Clayton, Minogue, Hsuan: Detergent-free isolation and characterization of cholesterol-rich membrane domains from trans-Golgi network vesicles. in Journal of lipid research 2011
Show all 5 Pubmed References
Human Polyclonal VPS45 Primary Antibody for ELISA, WB - ABIN250841
Nielsen, Christoforidis, Uttenweiler-Joseph, Miaczynska, Dewitte, Wilm, Hoflack, Zerial: Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. in The Journal of cell biology 2000
Human Polyclonal VPS45 Primary Antibody for ELISA, WB - ABIN188544
Rajasekariah, Eyre, Stanley, Walls, Sutherland: Molecular cloning and characterization of a cDNA encoding the human leucocyte vacuolar protein sorting (h1Vps45). in The international journal of biochemistry & cell biology 1999
A homozygous VPS45 p.E238K mutation is associated with severe congenital neutropenia with neurological impairment.
we identified a Thr224Asn mutation in the VPS45 gene in infants from consanguineous families who suffered from life-threatening neutropenia.
Defective endosomal intracellular protein trafficking due to biallelic mutations in VPS45 underlies a new immunodeficiency syndrome involving impaired neutrophil function.
Data implicate hVps45 and Rabenosyn-5 in post early endosome transport, and suggest that their interaction serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes.
A crucial role for mVps45 in the delivery of GLUT4 into its specialized, insulin-regulated compartment.
BEN1 and BEN2 are collectively required for polar PIN localization, for their dynamic repolarization, and consequently for auxin activity gradient formation and auxin-related developmental processes. [BEN2]
A functional characterization of AtVPS45 (for vacuolar protein sorting 45), a protein from the Sec1/Munc18 family in Arabidopsis (Arabidopsis thaliana) that interacts at the trans-Golgi network (TGN) with the SYP41/SYP61/VTI12 SNARE complex, is reported.
VPS45 normally suppresses lens fiber differentiation in the anterior region of lens epithelium by modulating TGFbeta and canonical Wnt signaling pathways.[Vps45]
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators.
, leucocyte vacuolar protein sorting 45
, vacuolar protein sorting 45A
, vacuolar protein sorting-associated protein 45
, vesicular transport protein rvps45
, vacuolar protein sorting protein 45
, Vacuolar protein sorting-associated protein 45
, vacuolar protein sorting 45
, vacuolar protein sorting 45 homolog
, vacuolar protein sorting 45 homolog (S. cerevisiae)
, SM/Sec1-family protein
, vacuolar protein sorting-associated protein 45-like
, LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 45