Browse our FUZ Proteins (FUZ)

Full name:: Fuzzy Homolog (Drosophila) Proteins (FUZ)

On www.antibodies-online.com are 5 Fuzzy Homolog (Drosophila) (FUZ) Proteins from 3 different suppliers available. Additionally we are shipping FUZ Antibodies (17) and many more products for this protein. A total of 25 FUZ products are currently listed.

Synonyms:: 2600013E07Rik, b2b1273Clo, FY, NTD, RGD1310608

list all proteins	Gene Name	GeneID	UniProt
	FUZ	70300	Q3UYI6
	FUZ	80199	Q9BT04
	FUZ	308577	Q3B756
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Mouse (Murine) Fuzzy Homolog (Drosophila) (FUZ) interaction partners

This paper reports a novel skull phenotype in a ciliopathic mutant mouse in which only a single calvarial bone plate encases the forebrain in mice lacking Fuz, an essential regulator of ciliogenesis.
Fuzzy appears to control subcellular localization of the core PCP (show BMP1 Proteins) protein Dishevelled (show DVL2 Proteins), recruiting it to Rab8 (show RAB8A Proteins)-positive vesicles and to the basal body and cilium. We show that loss of Fuzzy results in inhibition of PCP (show BMP1 Proteins) signaling
Using the ciliopathic Fuz mutant mouse, we find that high arched palate does not, as commonly suggested, arise from midface hypoplasia; rather, increased neural crest expands the maxillary primordia.
The data demonstrate a new model for coordination of Hh and Wnt (show WNT2 Proteins) signaling and reveal a Fuz-dependent negative feedback loop controlling Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia.
Fuz plays an important role in cilia formation, Hh signal transduction, and embryonic development in mammals.

Human Fuzzy Homolog (Drosophila) (FUZ) interaction partners

results in vitro show that FUZ is responsible for non-small-cell lung cancer (NSCLC) progression and metastasis, suggesting that FUZ can be a potential therapeutic target for NSCLC.

FUZ Protein Profile

Protein Summary

This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with FUZ

fuzzy planar cell polarity protein (FUZ)
fuzzy planar cell polarity protein (fuz)
protein fuzzy homolog (LOC100553811)
protein fuzzy homolog (LOC100650435)
fuzzy planar cell polarity protein (Fuz)

2600013E07Rik protein
b2b1273Clo protein
FY protein
NTD protein
RGD1310608 protein

Protein level used designations for FUZ

fuzzy homolog (Drosophila) , protein fuzzy homolog , fuzzy homolog , xfy

GENE ID	SPECIES
468957	Pan troglodytes
476409	Canis lupus familiaris
528818	Bos taurus
677733	Xenopus (Silurana) tropicalis
797090	Danio rerio
100030190	Monodelphis domestica
100052158	Equus caballus
100415347	Callithrix jacchus
100444085	Pongo abelii
100469667	Ailuropoda melanoleuca
100520080	Sus scrofa
100553811	Anolis carolinensis
100566499	Anolis carolinensis
100604127	Nomascus leucogenys
100650435	Bombus terrestris
70300	Mus musculus
80199	Homo sapiens
308577	Rattus norvegicus

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