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anti-Human HAND1 Antibodies:
anti-Rat (Rattus) HAND1 Antibodies:
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Human Monoclonal HAND1 Primary Antibody for ELISA, WB - ABIN969184
Dai, Cserjesi: The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
Human Monoclonal HAND1 Primary Antibody for ELISA, WB - ABIN966248
Firulli, Howard, McDaid, McIlreavey, Dionne, Centonze, Cserjesi, Virshup, Firulli: PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. in Molecular cell 2003
Show all 2 Pubmed References
Human Monoclonal HAND1 Primary Antibody for ELISA, WB - ABIN4316554
Lu, Du, Shan, Wang, Ma, Dong: Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture. in Biochemical and biophysical research communications 2016
Human Polyclonal HAND1 Primary Antibody for ICC, IF - ABIN4316555
Zhang, Chen, Ye, Wang, Wang, Yuan, Lin, Wu, Zhang, Lin: Wnt signaling promotes hindgut fate commitment through regulating multi-lineage genes during hESC differentiation. in Cellular signalling 2016
CatG (show CTSG Antibodies) can be used as a novel marker to distinguish different NK cell subsets and MARS116 is applicable to determine cell surface CatG (show CTSG Antibodies) activity by flow cytometry.
Results provide evidence that cathepsin G (show CTSG Antibodies) (GC) activates IGF-1R (show IGF1R Antibodies) by stimulating IGF-1 (show IGF1 Antibodies) release from MCF-7 cells, and that IGF-1R (show IGF1R Antibodies) activation is required for CG-induced cell aggregation.
Cleavage of the alarmins by Human mast cell chymase (show CMA1 Antibodies) and human neutrophil cathepsin G (show CTSG Antibodies) suggests a function in regulating excessive inflammation.
Strikingly, human pluripotent stem cell antibody array showed that Hand1 overexpression resulted in substantial decrease in pluripotency markers (Nanog (show NANOG Antibodies), Oct3/4 (show POU5F1 Antibodies), Otx2 (show OTX2 Antibodies), Flk1 (show KDR Antibodies)) suggesting that Hand1 expression may be essential to attenuate the EMT (show ITK Antibodies) and our findings underscore a novel role for Hand1 in medulloblastoma metastasis.
association of HAND1 loss-of-function mutation with increased susceptibility to Tetralogy of Fallot
These findings expand the phenotypic spectrum linked to HAND1 mutations, suggesting potential implications for the development of novelo prophylactic and therapeutic strategies for DORV.
HAND1 loss-of-function mutation is associated with familial dilated cardiomyopathy.
Data show that lactoferrin (LF (show LTF Antibodies)) increases the catalytic activity of cathepsin G (CatG (show CTSG Antibodies)) at physiological concentration.
CatG is an essential protease for regulating MHC I molecules
Combined expression of NKX2-5 (show NKX2-5 Antibodies), HAND1, and NOTCH1 (show NOTCH1 Antibodies) coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome.
a single nucleotide substitution in the hand1.S promoter was responsible for the reduced expression in the heart.
increased vascular endothelial growth factor(170) levels disturb Hand-1 expression in the region required for normal heart morphogenesis
a non-essential role for Hand1 in mouse limb morphogenesis, is reported.
Surviving Hand1;Hand2 (show HAND2 Antibodies) mutants display diminished cardiac function that is rescued by concurrent ablation of Hand-null cardiomyocytes. Collectively, we conclude that, within a mixed cardiomyocyte population, removal of defective myocardium and replacement with healthy endogenous cardiomyocytes may provide an effective strategy for cardiac repair.
Within the pharyngeal arches, the distal-most of the proximo-distally oriented subdomains of cranial neural crest cells, the distal cap, is marked by expression of the transcription factor Hand1 and gives rise to the ectomesenchymal derivatives of the lower incisors.
Data suggest the protection role of haploinsufficiency of heart and neural crest derivatives expressed transcript 1 protein (Hand1) after acute myocardial infarction (AMI (show CFD Antibodies)).
Hand1 is involved in proper osteogenesis of the bone collar via its control of Ihh (show IHH Antibodies). Hand1 overexpression in the osteochondral progenitors caused defective prenatal diaphysis ossification. Hand1 inhibited Runx2 (show RUNX2 Antibodies) transactivation of the Ihh (show IHH Antibodies) proximal promoter.
Re-expression of HAND1 in colon cancer cells induces terminal differentiation.
Hand1 phosphoregulation in the distal arch neural crest has a critical role in craniofacial morphogenesis
Suggest that prenatal alcohol exposure causes the over-expression of DHAND (show HAND2 Antibodies) and EHAND by increasing H3K14ac in the fetal heart.
Hand1 is part of a novel regulatory pathway linking cardiac oxygen levels with oxygen consumption.
that Hand1 homodimer plays a dominant role during development and its expression dosage is critical for survival, whereas Hand1 heterodimers can be either dispensable or play a regulatory role to modulate the activity of Hand1 homodimer in vivo.
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.
class A basic helix-loop-helix protein 27
, extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1
, heart- and neural crest derivatives-expressed protein 1
, heart and neural crest derivatives expressed transcript 1
, heart and neural crest derivatives-expressed protein 1
, heart and neural crest derivatives expressed 1
, basic helix-loop-helix transcription factor HAND1
, eHAND basic helix-loop-helix transcription factor
, Heart- and neural crest derivatives-expressed protein 1
, helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast