Browse our anti-Heart and Neural Crest Derivatives Expressed 2 (HAND2) Antibodies

Human Heart and Neural Crest Derivatives Expressed 2 (HAND2) interaction partners

1. Study showed that thalidomide inhibited the TBX5/HAND2 physical interaction, and the in silico docking revealed that the same amino acids involved in the interaction of TBX5 with DNA are also involved in its binding to HAND2. Results establish a HAND2/TBX5 pathway implicated in heart development and diseases.

2. HAND2 mRNA and protein low expressed in endometrial carcinoma (EC) tissues, which suggested the degree of endometrial malignancy.

3. The results identify HAND2 loci associated with susceptibility to early onset atrial fibrillation in a Korean population.

4. These findings indicate that HAND2 loss-of-function mutation contributes to human CHD, perhaps via its interaction with GATA4 and NKX2.5.

5. HAND2 and microRNA-1 facilitated the early progress of human induced cardiomyocyte-like cells reprogramming.

6. this study is the first to report the association of a HAND2 loss-of-function mutation with an increased vulnerability to tetralogy of Fallot in humans, which provides novel insight into the molecular mechanism underpinning congenital heart disease

7. HAND2-mediated proteolysis negatively regulates the function of estrogen receptor alpha.

8. suggest that HAND2 plays a key role in the regulation of progestin-induced decidualization of human endometrial stromal cells.

9. Reduced protein expression of HAND2 in the myenteric plexus of the aganglionic segment would suggest that HAND2 was involved in the pathogenesis of Hirschsprung disease.

10. Increased HAND2 methylation was a feature of premalignant endometrial lesions and was seen to parallel a decrease in RNA and protein levels.

11. Overdosage of Hand2 causes limb and heart defects in the human chromosomal disorder partial trisomy distal 4q.

12. No evidence of linkage between HAND2 and CL/P was obtained. Levelss of exclusion were obtained with different inheritance models. results did not support HAND2 in CL/P

13. Expression analyses on both Hand2 conditionally null and hypomorphic backgrounds demonstrate that Hand2 is required for reporter activation in a gene dosage-dependent manner during sympathetic neurogenesis.

14. Data suggest Hand2 plays an important role in decidualization; expression of Hand2 is significantly increased in response to prostaglandin E2.

15. These data suggest that cytokines can inhibit norepinephrine transporter expression through downregulation of Hand2 or Gata3 in cultured sympathetic neurons, but axotomy in adult animals selectively suppresses Hand2 expression.

16. Hand2 performs an essential role during transgenic epicardialization, directly impacting epicardial cell differentiation and formation of the coronary vasculature.

17. HAND2 may be a potential candidate gene of stenosis of the right ventricle, outflow tract.

18. effects of gene mutations on ventricular development

19. dHAND/E-protein (E2A, ME2, and ALF1) heterodimers have distinct DNA binding specificities

20. These results demonstrate the direct interactions of the Phox2a and b and dHAND transcription factors within a noradrenergic cell type

Mouse (Murine) Heart and Neural Crest Derivatives Expressed 2 (HAND2) interaction partners

1. Enrichment of induced cardiomyocytes derived from mouse fibroblasts can be achieved by reprogramming with cardiac transcription factors, Gata4, MEF2c, Tbx5, and Hand2.

2. Analysis reveals that altered Hand2 expression in the maxillary arch results in altered homeobox transcription factor regulation in the mandibular and maxillary processes and a transformation of the upper jaw into the lower jaw. The results of the present study also suggest that nested Hand2 expression in the mandibular arch is necessary for palatogenesis.

3. HAND2 directly regulates the molecular cascades initiating atrioventricular canal cardiac valve development.

4. Ptn may play a vital role in the progesterone-induced decidualization pathway via C/EBPB-cyclic AMP-Hand2 signaling.

5. Results demonstrate a change in Hand2 target genes during maturation of sympathetic neurons. Whereas Hand2 controls genes regulating noradrenergic differentiation during development, Hand2 seems to be involved in the regulation of genes controlling neurotransmission in adult sympathetic neurons.

6. Surviving Hand1;Hand2 mutants display diminished cardiac function that is rescued by concurrent ablation of Hand-null cardiomyocytes. Collectively, we conclude that, within a mixed cardiomyocyte population, removal of defective myocardium and replacement with healthy endogenous cardiomyocytes may provide an effective strategy for cardiac repair.

7. This study showed that Gja1 may act downstream of cAMP-PKA signal to mediate the effects of Acvr1 on the differentiation of uterine stromal cells through targeting Hand2.

8. transcription of a Hand2-associated long non-coding RNA, which we named upperhand (Uph), is required to maintain the super-enhancer signature and elongation of RNA polymerase II through the Hand2 enhancer locus

9. endocardial Hand2 is an integral downstream component of a Notch endocardium-to-myocardium signaling pathway and a direct transcriptional regulator of Neuregulin1.

10. analysis uncovers the transcriptional circuits that function in establishing distinct mesenchymal compartments downstream of HAND2 and upstream of SHH signaling

11. Suggest that prenatal alcohol exposure causes the over-expression of DHAND and EHAND by increasing H3K14ac in the fetal heart.

12. Hand2 loss-of-function dramatically reduces expression of Dopamine Beta Hydroxylase (Dbh), a gene encoding a crucial catecholaminergic biosynthetic enzyme

13. in vivo inhibition of miR-25 by a specific antagomir evoked spontaneous cardiac dysfunction and sensitized the murine myocardium to heart failure in a Hand2-dependent manner

14. overdosage of Hand2 is a major cause for the limb and heart defects phenotypes.

15. Hand2 and NFATC physically interact on the DEGS1 promoter in the hypoxic mouse heart.

16. Twist1, along with Hand2, is essential for the proximodistal patterning and development of the mandible and ossification.

17. Data indicate that mouse and zebrafish hand2 enhancers both drive transgene expression in the pharyngeal arches.

18. Results suggest that Hand2 is essential for neurogenesis, neurotransmitter specification and neural network patterning in the developing enteric nervous system.

19. Data suggest Hand2 plays an important role in decidualization (especially in response to PGE2) and in obtaining proper progesterone-dependent uterine sensitization required for implantation.

20. We now show that enteric neurogenesis is a quantitative function of Hand2 expression in mice.

Zebrafish Heart and Neural Crest Derivatives Expressed 2 (HAND2) interaction partners

1. hand2 and the co-expressed zinc-finger transcription factor osr1 have functionally antagonistic influences on kidney development. Together, our data suggest that hand2 functions in opposition to osr1 to balance the formation of kidney and vein progenitors by regulating cell fate decisions at the lateral boundary of the Iintermediate mesoderm

2. hand2 can drive cardiomyocyte production in multiple contexts and through multiple mechanisms

3. These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.

4. Data indicate that mouse and zebrafish hand2 enhancers both drive transgene expression in the pharyngeal arches.

5. reduction of fn1 function enables rescue of cardiac fusion in hand2 mutants

6. the expression and function of hand2 and dlx3b/4b/5a genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches

7. Our study reveals an unexpected role for Hand2, a key regulator of cell specification and differentiation, in modulating ECM remodeling during organogenesis

8. Hand2-endothelin 1 effector, patterns ventral pharyngeal cartilage

9. Hand2 is uniquely required for myocardial polarization.

10. These results demonstrate in vivo an essential and selective function of hand2 for the noradrenergic differentiation of sympathetic neurons, and implicates tfap2a and gata2 as downstream effectors.

11. Han is required in surrounding tissue, and not in a cell-autonomous manner, for thyroid development.

12. Data show that endoderm and hedgehog signaling, but not Hand2, regulate GDNF expression in the intestine, highlighting a central role of endoderm and Sonic hedgehog in patterning the intestine and the enteric nervous system.

13. Pbx acts with Hand2 in early myocardial differentiation