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IRX2 transcription factor might represent a novel metastasis associated protein that acts as a negative regulator of cellular motility and as a repressor of chemokine expression and loss of IRX2 expression could therefore contribute to early hematogenous dissemination of breast cancer by sustaining chemokine secretion and enabling mobilization of tumor cells.
IRX2 modulates the expression levels of MMP2 and VEGF in an AKTdependent manner.
The mechanism by which IRX2 promoted cell proliferation and invasion by activating AKT and MMP9 was detected.
Results revealed 3 genes highly predictive of event-free survival (EFS), beyond age and MLL status: FLT3, IRX2, and TACC2.
IRX2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease.
generation and phenotypic analysis of an Irx2-deficient mouse strain. Irx2-deficient mice are viable, are fertile, and appear to be normal.
This homeobox protein is expressed during early lung development.
This homeobox protein is expressed during digit development.
IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.
homeodomain protein IRXA2
, iroquois homeobox protein 2
, iroquois-class homeodomain protein IRX-2
, Iroquois related homeobox 2
, Iroquois related homeobox 5
, iroquois-class homeobox protein Irx6