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anti-Human OSR1 Antibodies:
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Human Monoclonal OSR1 Primary Antibody for ELISA - ABIN566802
Takahashi, Mori, Nomura, Khan, Araki, Zeniya, Sohara, Rai, Sasaki, Uchida: WNK4 is the major WNK positively regulating NCC in the mouse kidney. in Bioscience reports 2014
Osr1/Osr2 normally repress bmp4 (show BMP4 Antibodies) expression in the lateral plate mesoderm prior to respiratory specification.
nephrogenic transcription factors (osr1, osr2, hnf1b (show HNF1B Antibodies), lhx1 (show LHX1 Antibodies), pax8 (show PAX8 Antibodies))play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (show INHBA Antibodies), retinoic acid
Kir2.1 (show KCNJ2 Antibodies) and Kir2.3 (show KCNJ4 Antibodies), are activated by OSR1 (show OXSR1 Antibodies) through a motif variant, R-x-F-x-V/I.
Odd-skipped related 1 (OSR1) downregulated the activity of the Wnt (show WNT2 Antibodies) signaling pathway by suppressing the expression of sex-determining region Y (show SRY Antibodies)-box 9 (SOX9 (show SOX9 Antibodies)) and beta-catenin (show CTNNB1 Antibodies).
OSR1 (show OXSR1 Antibodies) was downregulated in RCC (show XRCC1 Antibodies) cells by promoter methylation. OSR1 (show OXSR1 Antibodies) can function as a tumor suppressor via inhibition of invasion and proliferation in RCC (show XRCC1 Antibodies) cells, possibly via upregulating tumor suppressor genes and downregulating oncogenes.
OSR1 (show OXSR1 Antibodies) was sequenced in 186 children with primary vesicoureteric reflux, and 17 have single nucleotide polymorphisms
In summary, our study implicated a gene network involving Tbx5 (show TBX5 Antibodies), Osr1 (show OXSR1 Antibodies) and Pcsk6 (show PCSK6 Antibodies) interaction in second heart field for atrial septation, providing a molecular framework for understanding the role of Tbx5 (show TBX5 Antibodies) in congenital heart disease ontogeny.
The findings of the present study showed, for the first time, the role of the OSR1 (show OXSR1 Antibodies) rs12329305 polymorphism in the development of congenital malformations in cases of stillborn/neonatal death.
OSR1 (show OXSR1 Antibodies) acts as a functional tumour suppressor in gastric cancer
OSR1 is expressed in human mesenchymal stem cells, the blastemal component of Wilms tumors and CD24+/CD133+ progenitor cells isolated from the mature kidney.
first report on molecular cloning and characterization of human OSR1 (show OXSR1 Antibodies)
Transcriptome and functional analyses reveal that Osr1(+) cells provide a critical pro-myogenic niche via the production of muscle connective tissue specific extracellular matrix components and secreted signaling factors.
Hypothalamic OSR1 expression is suppressed by enhanced postnatal (maternal) care, but elevated by inflammatory microglia.
In contrast to H2A-interacting proteins, the H2A.Z (show H2AFZ Antibodies)-interacting proteins are involved in transcriptional regulation. We found that the transcription factor Osr1 interacts with H2A.Z (show H2AFZ Antibodies) both in vitro and in vivo. It also mediates H2A.Z (show H2AFZ Antibodies) incorporation to a large number of target sites and regulates gene expression
These results indicate that OSR1 and SPAK (show STK39 Antibodies) cooperatively regulate NKCC1 (show SLC12A2 Antibodies)-dependent spermatogenesis in a SC-restricted manner.
Osr1 is a candidate gene implicated in the pathogenesis of vesicoureteric reflux and congenital abnormalities of the kidney and urinary tract in mice
Our data reveal that together SPAK (show STK39 Antibodies) and OSR1 play essential roles in the pathway along the distal convoluted tubules that responds to fluctuations in plasma potassium
These results indicate that Osr1 and Wt1 (show WT1 Antibodies) act synergistically to regulate nephron endowment by controlling metanephric mesenchyme specification during early nephrogenesis.
Tbx5 (show TBX5 Antibodies) and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation.
odd-skipped related 1 is involved in regulation of mammalian kidney development
ROMK1 (show KCNJ1 Antibodies) protein abundance and activity are down-regulated by SPAK (show STK39 Antibodies) and OSR1
hand2 (show HAND2 Antibodies) and the co-expressed zinc-finger transcription factor osr1 have functionally antagonistic influences on kidney development. Together, our data suggest that hand2 (show HAND2 Antibodies) functions in opposition to osr1 to balance the formation of kidney and vein progenitors by regulating cell fate decisions at the lateral boundary of the Iintermediate mesoderm
findings identify osr1 as a Nodal-induced, negative feedback regulator of Nodal signaling that acts at the earliest stages of endoderm differentiation to limit the number of endoderm progenitors.
Our results place osr1 in a framework of transcriptional regulators that control the expression of podocin and nephrin (show NPHS1 Antibodies) and thereby mediate podocyte differentiation.
The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b (show WNT2B Antibodies) to maintain pectoral fin development.
osr1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate.
Transcription factor that plays a role in the regulation of embryonic heart and urogenital development (By similarity).
odd-skipped related 1 (Drosophila)
, protein odd-skipped-related 1
, zinc finger transcription factor
, odd-skipped homolog
, oxidative-stress responsive 1