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Osr1/Osr2 normally repress bmp4 (show BMP4 Proteins) expression in the lateral plate mesoderm prior to respiratory specification.
nephrogenic transcription factors (osr1, osr2, hnf1b (show HNF1B Proteins), lhx1 (show LHX1 Proteins), pax8 (show PAX8 Proteins))play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (show INHBA Proteins), retinoic acid
OSR1 (show OXSR1 Proteins) was downregulated in RCC (show XRCC1 Proteins) cells by promoter methylation. OSR1 (show OXSR1 Proteins) can function as a tumor suppressor via inhibition of invasion and proliferation in RCC (show XRCC1 Proteins) cells, possibly via upregulating tumor suppressor genes and downregulating oncogenes.
OSR1 (show OXSR1 Proteins) was sequenced in 186 children with primary vesicoureteric reflux, and 17 have single nucleotide polymorphisms
Both SPAK (show STK39 Proteins) and OSR1 (show OXSR1 Proteins) kinases entering cells through exosomes are preferentially expressed at the plasma membrane and that the kinases in exosomes are functional and maintain NKCC1 (show SLC12A2 Proteins) in a phosphorylated state.
In summary, our study implicated a gene network involving Tbx5 (show TBX5 Proteins), Osr1 (show OXSR1 Proteins) and Pcsk6 interaction in second heart field for atrial septation, providing a molecular framework for understanding the role of Tbx5 (show TBX5 Proteins) in congenital heart disease ontogeny.
SPAK (show STK39 Proteins) and OSR1 (show OXSR1 Proteins) are both stimulators of Kir2.1 (show KCNJ2 Proteins) activity.
SPAK (show STK39 Proteins) and OSR1 (show OXSR1 Proteins) are powerful stimulators of the intestinal Na+-coupled phosphate co-transporter NaPi-IIb (show SLC34A2 Proteins)
OSR1 (show OXSR1 Proteins) protein has both the potential to up-regulate KCNQ1 (show KCNQ1 Proteins)/E1 protein abundance in the cell membrane, an effect possibly participating in the regulation of cell volume, excitability, epithelial transport and metabolism.
SPAK (show STK39 Proteins) and OSR1 (show OXSR1 Proteins) are powerful negative regulators of the excitatory glutamate (show GRIN1 Proteins) transporters EAAT1 (show SLC1A3 Proteins) and EAAT2 (show SLC1A2 Proteins).
SPAK (show STK39 Proteins) and OSR1 (show OXSR1 Proteins) are negative regulators of EAAT3 (show SLC1A1 Proteins) activity
OSR1 has the capacity to downregulate the peptide transporters PEPT1 and PEPT2 by decreasing the carrier protein abundance in the cell membrane
Osr1 is a candidate gene implicated in the pathogenesis of vesicoureteric reflux and congenital abnormalities of the kidney and urinary tract in mice
Our data reveal that together SPAK (show STK39 Proteins) and OSR1 play essential roles in the pathway along the distal convoluted tubules that responds to fluctuations in plasma potassium
These results indicate that Osr1 and Wt1 (show WT1 Proteins) act synergistically to regulate nephron endowment by controlling metanephric mesenchyme specification during early nephrogenesis.
Tbx5 (show TBX5 Proteins) and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation.
odd-skipped related 1 is involved in regulation of mammalian kidney development
ROMK1 (show KCNJ1 Proteins) protein abundance and activity are down-regulated by SPAK (show STK39 Proteins) and OSR1
study identifies a separation of functions for the WNK1 (show WNK1 Proteins)-activated protein kinases OSR1 and SPAK (show STK39 Proteins) in mediating proliferation, invasion, and gene expression in endothelial cells
WNK 1 (show WNK1 Proteins), 3, 4, OSR1, and SPAK (show STK39 Proteins) signaling system known to play a role in regulating the phosphorylation status, and hence activity of the CCCs in other tissues, is also present in the rat and human lenses.
Osr1 plays crucial roles in Six2 (show SIX2 Proteins)-dependent maintenance of nephron progenitors during mammalian nephrogenesis.
Data indicate that Activin A (show INHBA Proteins) and retinoic acid (RA) induced theto embryonic stem cells (mESCs) expression of marker genes and proteins for intermediate mesoderm, odd-skipped related 1 (Osr1) and Wilms Tumor 1 (Wt1 (show WT1 Proteins)).
hand2 (show HAND2 Proteins) and the co-expressed zinc-finger transcription factor osr1 have functionally antagonistic influences on kidney development. Together, our data suggest that hand2 (show HAND2 Proteins) functions in opposition to osr1 to balance the formation of kidney and vein progenitors by regulating cell fate decisions at the lateral boundary of the Iintermediate mesoderm
findings identify osr1 as a Nodal-induced, negative feedback regulator of Nodal signaling that acts at the earliest stages of endoderm differentiation to limit the number of endoderm progenitors.
Our results place osr1 in a framework of transcriptional regulators that control the expression of podocin and nephrin (show NPHS1 Proteins) and thereby mediate podocyte differentiation.
The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b (show WNT2B Proteins) to maintain pectoral fin development.
osr1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate.
Transcription factor that plays a role in the regulation of embryonic heart and urogenital development (By similarity).
odd-skipped related 1 (Drosophila)
, protein odd-skipped-related 1
, zinc finger transcription factor
, odd-skipped homolog
, oxidative-stress responsive 1