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anti-Human OVOL2 Antibodies:
anti-Mouse (Murine) OVOL2 Antibodies:
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Human Polyclonal OVOL2 Primary Antibody for ICC, IF - ABIN4342026
Ito, Tsuji, Ohno, Uchi, Nakahara, Hashimoto-Hachiya, Yoshida, Yamamoto, Oda, Furue: Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma. in The American journal of pathology 2016
Show all 5 Pubmed References
Taken together, this study suggests that the OVOL1 (show OVOL1 Antibodies)-OVOL2 axis is a key modulator of c-Myc (show MYC Antibodies) expression in the shift from in situ epidermal malignancy (Bowen's disease) to invasive squamous cell carcinoma.
OVOL2 antagonizes TGF-beta (show TGFB1 Antibodies) signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis.
the OVOL2 promoter variant c.-307T>C was herein identified in the original family that established the posterior polymorphous corneal dystrophy 1 locus.
OVOL2 maintains the transcriptional program of human corneal epithelium cells.
Ovol2 can suppress migration and invasion ability of A549 cells, and prevent EMT (show ITK Antibodies) by inhibition of Twist1 (show TWIST1 Antibodies) transcription directly.
congenital hereditary endothelial dystrophy 1 (CHED1) and CHED2 (show SLC4A11 Antibodies) loci on chromosome 20 and the collagen, type VIII (show COX8A Antibodies), alpha-2 (COL8A2 (show COL8a2 Antibodies)) gene were excluded by linkage and haplotype analyses.
that the OVOL1 (show OVOL1 Antibodies)-OVOL2 axis may actively contribute to cell differentiation and proliferation in the hair bulb
OVOL2 is a colorectal tumor suppressor (show DCC Antibodies) that blocks WNT (show WNT2 Antibodies) signaling by facilitating the recruitment of histone deacetylase 1 (show HDAC1 Antibodies) to the TCF4 (show TCF4 Antibodies)-beta-catenin (show CTNNB1 Antibodies) complex.
data demonstrate that all four mutated OVOL2 promoters exhibited more transcriptional activity than the corresponding wild-type promoter
Molecular phylogeny of OVOL1, OVOL2 and OVOL3 genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions in humans and other species
Association of a chromosomal rearrangement event with mouse posterior polymorphous corneal dystrophy and alterations in Csrp2bp (show CSRP2BP Antibodies), Dzank1 (show DZANK1 Antibodies), and Ovol2 gene expression have been reported.
a Grhl2 (show GRHL2 Antibodies)/Ovol2 network controls Cldn4 (show CLDN4 Antibodies) and Rab25 (show RAB25 Antibodies) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
We show that ER71 (show ETV2 Antibodies) directly interacts with OVOL2 and that such interaction is critical for FLK1 (show KDR Antibodies)(+) cell generation and their differentiation into downstream cell lineages.
Deletion of Ovol2 blocks mammary ductal morphogenesis, depletes stem and progenitor cell reservoirs, and leads epithelial cells to undergo EMT (show ITK Antibodies) .
Ovol2 acts downstream of the BMP pathway in the cell fate decision between neuroectoderm and mesendoderm to ensure proper germ layer development.
Ovol2/MOVO may play an important role in the XY body during spermatogenesis, possibly in the processes of XY body formation and meiotic sex chromosome inactivation.
Ovol2 transcription was dramatically reduced in testes from blind-sterile mice, suggesting that Ovol2 is expressed in male germ cells
Ovol2 is a key regulator of neural development and reveal a previously unexplored role for Ovo genes in mammalian embryogenesis.
Expression of Ovol2 was up-regulated in Ovol1 (show OVOL1 Antibodies)-deficient epidermis; Ovol1 (show OVOL1 Antibodies) represses the activity of Ovol2 promoter in a DNA binding-dependent manner identifying Ovol2 as a downstream target of Ovol1 (show OVOL1 Antibodies).
DNA-binding protein that binds to the 5'-GGGGGG-3' core sequence. Probably acts as a transcription regulator.
ovo-like 2 (Drosophila)
, ovo-like 2
, transcription factor Ovo-like 2
, zinc finger protein 339
, MOVO-B zinc finger protein
, MOVO-C zinc finger protein
, OVO homolog-like 2
, zinc finger OVO2
, zinc finger protein mOVO