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Human Monoclonal OXSR1 Primary Antibody for ELISA, WB - ABIN564274
Chiga, Rafiqi, Alessi, Sohara, Ohta, Rai, Sasaki, Uchida: Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. in Journal of cell science 2011
Show all 5 Pubmed References
Human Monoclonal OXSR1 Primary Antibody for IF, ELISA - ABIN564266
Naguro, Umeda, Kobayashi, Maruyama, Hattori, Shimizu, Kataoka, Kim-Mitsuyama, Uchida, Vandewalle, Noguchi, Nishitoh, Matsuzawa, Takeda, Ichijo: ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney. in Nature communications 2012
Show all 2 Pubmed References
Human Monoclonal OXSR1 Primary Antibody for ELISA, WB - ABIN564275
Susa, Sohara, Rai, Zeniya, Mori, Mori, Chiga, Nomura, Nishida, Takahashi, Isobe, Inoue, Takeishi, Takeda, Sasaki, Uchida: Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice. in Human molecular genetics 2014
Human Polyclonal OXSR1 Primary Antibody for ICC, IF - ABIN4342122
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
the WNK-regulated SPAK (show STK39 Antibodies)/OSR1 kinases directly phosphorylate the N[K]CCs (show CCS Antibodies) and KCCs, promoting their stimulation and inhibition respectively.
SPAK (show STK39 Antibodies) and OSR1, which are often coexpressed in cells, can form functional heterodimers.
Data show that intracellular association between WNK1 (show WNK1 Antibodies) and oxidative stress-responsive 1 (OSR1) is required for stimulation of OSR1 and Na(+), K(+), Cl(-)-Cotransporter NKCC1 (show SLC12A2 Antibodies) and NKCC2 (show SLC12A1 Antibodies) activities by osmotic stress.
OXSR1 and WNK3 (show WNK3 Antibodies) transcripts were substantially overexpressed in subjects with schizophrenia relative to comparison subjects.
isolation and characterization of OSR1 (oxidative stress-responsive 1), one of two human Fray homologs. OSR1 is a 58-kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines
WNK1 (show WNK1 Antibodies) and SPAK (show STK39 Antibodies)/OSR1 mediate the hypotonic stress signaling pathway to cation-chloride-coupled cotransporters
OXSR1 kinase is shown to interact with the three RELT (show RELT Antibodies) family members RELT (show RELT Antibodies), RELL1, and RELL2 by in vitro co-immunoprecipitation; additionally, OXSR1 phosphorylates RELT (show RELT Antibodies) family members in an in vitro kinase assay.
data establish that the CCT (show FLVCR2 Antibodies) domain functions as a multipurpose docking site, enabling SPAK (show STK39 Antibodies)/OSR1 to interact with substrates (NKCC1 (show SLC12A2 Antibodies)) and activators (WNK1 (show WNK1 Antibodies)/WNK4 (show WNK4 Antibodies))
OSR1 and sterile20-related, proline-, alanine-rich kinase are likely links between WNK lysine deficient protein kinase 1 (show WNK1 Antibodies) and solute carrier (show SERTAD2 Antibodies) family 12 in a pathway that contributes to volume regulation and blood pressure homeostasis in mammals
These results provide the first molecular insight into the mechanism by which the SPAK (show STK39 Antibodies) and OSR1 kinases specifically recognize their upstream activators and downstream substrates.
increased phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter in obesity and identifies a new role for AMP-activated protein kinase in regulating the activity of oxidative stress responsive 1 kinase-related proline-alanine-rich protein kinase
OSR1 (show OSR1 Antibodies) is expressed in intestine and partial WNK insensitivity of OSR1 (show OSR1 Antibodies) increases intestinal Na( )/H( ) exchanger activity and colonic epithelium Na( ) channel activity
Data indicate that SPAK (show STK39 Antibodies) and OSR1 (show OSR1 Antibodies) function interdependently in the distal convoluted tubule (DCT (show DCT Antibodies)) to positively regulate thiazide-sensitive sodium-chloride cotransporter (show SLC12A3 Antibodies), NCC (show SLC12A3 Antibodies).
Partial OSR1 (show OSR1 Antibodies) deficiency influences Na(+)/H(+) exchanger activity, ROS (show ROS1 Antibodies) formation, and migration of dendritic cells.
Results clearly establish that PHAII caused by the WNK4 (show WNK4 Antibodies) D561A mutation is dependent on the activation of the WNK-OSR1 (show OSR1 Antibodies)/SPAK (show STK39 Antibodies)-NCC (show SLC12A3 Antibodies) cascade.
Two Ste20-like (show STK25 Antibodies) kinases that bind and phosphorylate NKCC1 (show SLC12A2 Antibodies): Ste20 (show STK24 Antibodies)-related proline-alanine-rich kinase (SPAK (show STK39 Antibodies)) and oxidative-stress response 1 (OSR1 (show OSR1 Antibodies)), were identified.
In the kidneys, NKCC2 (show SLC12A1 Antibodies) but not NCC (show SLC12A3 Antibodies) is the main target of OSR1 (show OSR1 Antibodies) and the reduced p-NKCC2 (show SLC12A1 Antibodies) in KSP-OSR1 (show OSR1 Antibodies)(-/-) mice may lead to a Bartter-like syndrome.
phosphorylation states of NCC (show SLC12A3 Antibodies) and OSR1 (show OSR1 Antibodies)/SPAK (show STK39 Antibodies) (Gene: Oxsr1, GeneID: 108737) were increased by low-salt diets and decreased by high-salt diets
OSR1 (show OSR1 Antibodies), a kinase closely related to SPAK (show STK39 Antibodies), exhibited similar kinase properties and similar functional activation of NKCC1 (show SLC12A2 Antibodies) when coexpressed with WNK4 (show WNK4 Antibodies).
review: NCC (show SLC12A3 Antibodies) in the distal convoluted tubule plays a critical role in NaCl and, indirectly, in K+ homeostasis; regulation by SPAK (show STK39 Antibodies)/OSR1 (show OSR1 Antibodies) kinases and WNKs.
The gene shows 92.8% nucleotide identity and 95.5% amino acid identity with human OSR1 (show OSR1 Antibodies).
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.
oxidative stress-responsive 1 protein
, oxidative-stress responsive 1
, serine/threonine-protein kinase OSR1
, oxidative stress-responsive 1
, oxidative stress-responsive protein 1
, oxidative stress-responsive serine-rich protein 1
, peroxide-inducible transcript 1 protein
, Oxidative stress-responsive 1 protein