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Data indicate that Phactr4 acts as a tumor suppressor that is deleted and mutant in several cancers.
The authors show that rat Phactr1 inhibits PP1 activity in vitro, and mouse Phactr4 coimmunoprecipitates with actin and PP1 in human cells.
The Phactr4 forms functional associations with intermediate filament networks in adult neural stem cells.
Data discloses the central role of Phactr4 in a feedback loop, where actin monomers regulate their own number via the activation of a key regulator of actin dynamics.
This study demonistrated that the mRNA expression of phactr4 was progressively increased in the injury penumbra (show TSPAN33 Proteins).
hactr4 negatively regulates integrin signaling through the RHO/ROCK pathway and coordinates protein phosphatase 1 (show PPP1CB Proteins) (PP1 (show PPP1CC Proteins)) with cofilin (show CFL1 Proteins) activity to regulate cytoskeletal dynamics
Phactr4 is critical for the spatially and temporally regulated transition in proliferation through differential regulation of PP1 and the cell cycle during neurulation and eye development
This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene.
phosphatase and actin regulator 4
, phosphatase and actin regulator 4B
, protein Humpty dumpty