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High MST2 expression is associated with malignant melanoma.
Here, the authors discover SAV1 (show SAV1 Proteins)-mediated inhibition of the PP2A (show PPP2R4 Proteins) complex STRIPAK(SLMAP (show SLMAP Proteins)) as a key mechanism of MST1 (show MST1 Proteins)/2 activation.
Through a comprehensive set of biochemical, biophysical, mutational and structural studies, we quantitatively assess how phosphorylation of MOB1A (show MOBKL1B Proteins) regulates its interaction with both MST (show MAP3K10 Proteins) kinases and LATS/NDR (show STK38 Proteins) family kinases in vitro.
In this study, we investigated the mechanisms behind the recruitment of MST1 and MST2 kinases to MOB1, which facilitate signal transmission in the Hippo pathway by bringing the MST1 and MST2 kinases in close vicinity to their substrates, the LATS family kinases.
Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1 (show MST1 Proteins)/2)/YAP (show YAP1 Proteins) signaling, and that inhibition of miR (show MLXIP Proteins)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (show SOX2 Proteins) and SALL4 (show SALL4 Proteins).
These findings reveal a novel layer of regulation for MST2 in mitosis and its role in tumorigenesis.
TNFAIP8 regulates Hippo (MST1/2) signaling through its interaction with LATS1.
Data suggest that Hippo (MST1 (show MST1 Proteins)/2 protein kinases) - Yes associated protein 1 (YAP (show YAP1 Proteins)) pathway involved in carcinogenesis of pancreatic cancer and in the inhibition effect of stiehopus japonieus acidic mucopolysaccharide (SJAMP) to the proliferation of pancreatic cancer cell.
H-ras (show HRAS Proteins), via an Erk (show EPHB2 Proteins)-dependent mechanism, downregulates Mst1 (show MST1 Proteins)/Mst2 activity by inducing the formation of inactive Mst1 (show MST1 Proteins)/Mst2 heterodimers.
Results show that STK3 is targeted by Casp6 (show CASP6 Proteins) and demonstrate that alterations in STK3 protein expression levels and post-translational modifications are detected in a cellular model of HD and caspase (show CASP3 Proteins)-mediated generation of STK3 fragments observed under conditions of stress in cells expressing mhtt.
It is involved in apoptosis and serine/threonine kinase 3 (STK3 (show PKN1 Proteins)) is a recently identified caspase-6 (show CASP6 Proteins) substrate.
Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 (show MST1 Proteins) and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (show YAP1 Proteins) target genes and hepatocyte proliferation.
Studies indicate that Hippo (Hpo (show GFER Proteins); MST1 (show MST1 Proteins)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Mst2 is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB (show NFKB1 Proteins) pathway
the TLR-Mst1 (show MST1 Proteins)-Mst2-Rac (show AKT1 Proteins) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
These data indicate that that inhibition of mammalian sterile 20-like kinase 1 (show STK4 Proteins) rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy
Phosphorylation of LC3 (show MAP1LC3A Proteins) by the STK3 (show PKN1 Proteins) and STK4 is essential for autophagy.
These results identify MST2, not MST1 (show MST1 Proteins), as a critical regulator of caspase (show CASP3 Proteins)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart
Mst1 (show MST1 Proteins)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (show MST1 Proteins)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, STE20-like kinase MST2
, mammalian STE20-like protein kinase 2
, serine/threonine kinase 3 (STE20 homolog, yeast)
, serine/threonine kinase 3 (Ste20, yeast homolog)
, serine/threonine-protein kinase 3
, serine/threonine-protein kinase Krs-1
, protein kinase homolog
, serine/threonine kinase 3 (STE20 homolog)