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Data show that von Hippel-Lindau-binding protein 1 (VBP1) enhances the stability of von Hippel-Lindau tumor suppressor protein (pVHL) and facilitates pVHL-mediated ubiquitination of hypoxia-inducible factor 1, alpha subunit (HIF-1alpha).
VBP1 acts together with p97 to regulate hMSH4 degradation.
binds to HIF-1 alpha and regulates the function of HIF-1 alpha
VBP1 and cullin2/von Hippel-Lindau are required for proper HIV-1 expression at a step between integrase-dependent proviral integration into the host genome and transcription of viral genes
The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. Because it functions as a chaperone protein, it is suspected that it may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm.
prefoldin subunit 3
, Prefoldin subunit 3
, VHL binding protein-1
, VHL-binding protein 1
, prefoldin 3
, von Hippel-Lindau-binding protein 1