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Rat (Rattus) PGF Protein expressed in Escherichia coli (E. coli) - ABIN2126310
Zhang, Zhao, Yuan, Wu, Jiang, Luo, Zhao: Knockdown of placental growth factor (PLGF) mitigates hyperoxia-induced acute lung injury in neonatal rats: Suppressive effects on NFκB signaling pathway. in International immunopharmacology 2016
Human PGF Protein expressed in Escherichia coli (E. coli) - ABIN413725
Ding, Huang, Song, Gao, Yuan, Wang, Cai, Fu, Luo: NFAT1 mediates placental growth factor-induced myelomonocytic cell recruitment via the induction of TNF-alpha. in Journal of immunology (Baltimore, Md. : 1950) 2010
PGF promotes epithelial-mesenchymal transition-like changes in retinal pigment epithelium cells under hypoxia by activating the NF-kappaB (show NFKB1 Proteins) signaling pathway.
PGF expression may have a role in lymphatic invasion, poorer response to chemotherapy and unfavorable prognosis of patients with serous epithelial ovarian cancer
A single measurement of sFlt-1/PlGF ratio at third trimester to predict pre-eclampsia and intrauterine growth retardation occurring after 34weeks of pregnancy.
The levels of sFlt-1, PlGF, and the sFlt-1/PlGF ratio in pre-eclamptic women with an onset at < 32 weeks were sig (show PICALM Proteins)- ni fi cantly di ff erent from those in women with an onset at >/=32-33 weeks.
In urban Mozambican women with symptoms and/or signs suggestive of preeclampsia, low maternal plasma PlGF concentrations are associated with increased risks of adverse pregnancy outcomes, especially early delivery and stillbirth.
An sFlt-1:PlGF ratio above 655 is not predictive of impaired perinatal outcomes, and insufficiently reliable for predicting outcomes in cases with clinical signs of preeclampsia.
The maternal sFlt-1 to PlGF ratio in women with hypertensive disorders in pregnancy carries prognostic value for the development of preeclampsia.
Data suggest that PGF and PAPPA (show PAPPA Proteins) serve as serum biomarkers for early diagnosis of gestational hypertension. These studies were conducted at antenatal clinics in Ghana using blood from women between 8 and 13 weeks gestation. (PGF = placental growth factor; PAPPA (show PAPPA Proteins) = pregnancy-associated plasma protein-A (show PAPPA Proteins))
Lower umbilical cord PlGF levels are associated with lower birth weight, deviating fetal growth patterns, and a higher odds of fetal growth retardation.
Data suggest that circulating PGF levels fall by nearly one quarter during term labor (but not during elective caesarean section).
elevated PlGF levels may contribute to recruitment and activation of leukocytes. This can subsequently lead to increased pathology of affected organs in addition to mediating acute hypoxia/reoxygenation-triggered vaso-occlusion under sickle cell disease conditions.
Data indicate that VEGF-B (show VEGFB Proteins) is a high-affinity VEGFR-1 (show FLT1 Proteins) ligand that, unlike PIGF (show PIGF Proteins), cannot efficiently induce signaling downstream of VEGFR-1 (show FLT1 Proteins).
the lack of PIGF (show PIGF Proteins) may have contributed to the delayed angiogenic response and the prothrombotic phenotype observed in the PIGF (show PIGF Proteins)(-/-)animals.
Overexpression of VEGF (show VEGFA Proteins) but not PIGF (show PIGF Proteins) exacerbated the lipopolysaccharide-mediated toxic effects, supporting a pathophysiological role for VEGF (show VEGFA Proteins) in mediating the sepsis phenotype.
Findings indicate that placental growth factor (PlGF) plays an important role in liver fibrosis-associated angiogenesis and that blockage of PlGF could be an effective strategy for chronic liver disease.
Data demonstrate that PlGF is expressed in vivo and that its expression is restricted to the areas of the tumors where the highest levels of hypoxia occur. Also, hypoxia activates PlGF expression in cultured lymphatic endothelial cells.
Study provides mechanistic and clinical evidence that decreased PLGF levels in the placenta after in utero alcohol exposure are associated to brain angiogenesis defects. Measurement of PLGF levels at birth in the placenta or the fetal blood may serve as a predictive marker for subsequent neurodevelopmental outcomes of exposed fetuses.
PGF (show PTGFR Proteins) deficiency is associated with impaired cerebral vascular development in mice.
PlGF inhibition attenuates PERK (show EIF2AK3 Proteins) activation, likely by tempering hypoxia in HCC (show FAM126A Proteins) via vessel normalisation. The UPR is able to regulate PlGF expression, suggesting the existence of a feedback mechanism for hypoxia-mediated UPR
Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13 (show IL13 Proteins).
Study reports polymorphisms in the bovine PGF gene significantly associated with the maternal effect on stillbirth and calving ease in animals under selection.
placenta growth factor expression is regulated by both VEGF (show VEGFA Proteins) and hyperglycaemia via VEGFR-2 (show KDR Proteins)
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.
placenta growth factor
, placental growth factor, vascular endothelial growth factor-related protein
, placenta growth factor-like