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Human PGF Protein expressed in Escherichia coli (E. coli) - ABIN413725
Ding, Huang, Song, Gao, Yuan, Wang, Cai, Fu, Luo: NFAT1 mediates placental growth factor-induced myelomonocytic cell recruitment via the induction of TNF-alpha. in Journal of immunology (Baltimore, Md. : 1950) 2010
Rat (Rattus) PGF Protein expressed in Escherichia coli (E. coli) - ABIN2126310
Zhang, Zhao, Yuan, Wu, Jiang, Luo, Zhao: Knockdown of placental growth factor (PLGF) mitigates hyperoxia-induced acute lung injury in neonatal rats: Suppressive effects on NFκB signaling pathway. in International immunopharmacology 2016
Altered antiangiogenic state because of altered circulating PlGF leads to Preeclampsia.Ratio of sFlt1 (show FLT1 Proteins)/PlGF correlates with Preeclampsia phenotypes.
Gestation-adjusted sEng, sFlt-1 and PlGF levels were 11%, 36%, and 30%, respectively, lower in women who later suffered miscarriage compared with unaffected pregnancies.
the optimal discrimination cut-off for each cytokine: sVEGFR-1 (2124.5pg/mL), IL-6 (show IL6 Proteins) (40.2pg/mL), VEGF-A (show VEGFA Proteins) (1060.1pg/mL), Angiopoeintin-2 (913.7pg/mL), uPA (show PRAP1 Proteins) (248.1pg/mL), sHER-2/neu (show ERBB2 Proteins) (5010pg/mL) and PLGF (93.4pg/mL). For the very first time, a novel cytokine profile associated with cancer metastasis to the paratracheal lymph nodes were reported.
The results of this study showed that PlGF expression significantly decreased at recurrence glioblastoma after adiotherapy-temozolomide.
From a clinical point of view, PLGF could be considered a valid diagnostic test for the detection of primary and recurrent bladder cancer. In patients with recurrent bladder cancer, plasma PLGF levels can differentiate individuals at risk of tumor recurrence.
Lower maternal PlGF concentration is associated with intrapartum fetal compromise and poorer condition of the newborn. Maternal PlGF levels may be useful as a component of a risk stratification tool for intrapartum fetal compromise in apparently 'low risk' term pregnancies prior to labour.
Study provides mechanistic and clinical evidence that decreased PLGF levels in the placenta after in utero alcohol exposure are associated to brain angiogenesis defects. Measurement of PLGF levels at birth in the placenta or the fetal blood may serve as a predictive marker for subsequent neurodevelopmental outcomes of exposed fetuses.
This effect was reversed by the addition of PlGF neutralising antibody to the conditioned medium.
Results show that both FLT1 (show FLT1 Proteins) and PGF are overexpressed in the circulating tumor cells (CTCs) of patients with breast cancer. Also, a functional interaction of sFlt1 (show FLT1 Proteins) and PGF was found, suggesting that their overexpression in tumor cells inhibits CTCs entering the peripheral blood.
Identify a novel cis (show CISH Proteins)-acting sequence (-369 to -320) at the placental growth factor promoter, which was critical for mediating the basal and DLX3 (show DLX3 Proteins)/GCM1 (show GCM1 Proteins)-dependent PGF promoter activities.
PGF (show PTGFR Proteins) deficiency is associated with impaired cerebral vascular development in mice.
PlGF inhibition attenuates PERK (show EIF2AK3 Proteins) activation, likely by tempering hypoxia in HCC (show FAM126A Proteins) via vessel normalisation. The UPR is able to regulate PlGF expression, suggesting the existence of a feedback mechanism for hypoxia-mediated UPR
Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13 (show IL13 Proteins).
Data indicate that placental growth factor (PlGF) is needed in the spleen to allow the activation of T cells and blood pressure raising.
Placental growth factor promotes differentiation of bone marrow-derived macrophages and enhanced vascular endothelial cell proliferation.
PLGF in LC cells induced macrophage polarization in vivo, and significantly promoted the growth of LC.
PLGF is upregulated in vascular cells in response to fluid shear stress.
Data suggests that PLGF may target islet endothelia to release growth factors activating PI3k signalling in beta cells to increase their proliferation. In Pre-Eclampsia, PLGF reduction impairs these processes resulting in gestational diabetes mellitus.
The neutrophil elastase (show ELANE Proteins)-PlGF-JNK (show MAPK8 Proteins)/PKCdelta (show PKCd Proteins) pathway contributes to the pathogenesis of lung epithelial cell apoptosis and emphysema.
Study reports polymorphisms in the bovine PGF gene significantly associated with the maternal effect on stillbirth and calving ease in animals under selection.
placenta growth factor expression is regulated by both VEGF (show VEGFA Proteins) and hyperglycaemia via VEGFR-2 (show KDR Proteins)
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.
placental growth factor, vascular endothelial growth factor-related protein
, placenta growth factor
, placenta growth factor-like