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anti-Human AES Antibodies:
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Human Polyclonal AES Primary Antibody for ICC, ELISA - ABIN1001757
Martin, Vuori: Regulation of Bcl-2 proteins during anoikis and amorphosis. in Biochimica et biophysica acta 2004
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Human Polyclonal AES Primary Antibody for ICC, ELISA - ABIN1001758
Miyasaka, Choudhury, Hou, Li: Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. in European journal of biochemistry / FEBS 1993
Show all 4 Pubmed References
Human Polyclonal AES Primary Antibody for IHC (fro), WB - ABIN2477291
Link, Henneberg, Hövener: [Control of respirator pressure and drainage of the anesthetic gases with Kuhn's device in pediatric anesthesia (author's transl)]. in Der Anaesthesist 1976
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Results suggest that amino enhancer of split protein (AES) plays an important role in controlling tumor growth and metastasis of prostate cancer (PCa (show FLVCR1 Antibodies)) by regulating both androgen receptor (AR (show AR Antibodies)) and Notch (show NOTCH1 Antibodies) signaling pathway.
results indicate that Aes may belong to a novel family of metastasis su (show YY2 Antibodies)ppressors with a CpG-island promoter enhancer, and it is regulated transcriptionally
heat shock cognate 70 (HSC70 (show HSPA8 Antibodies)) is an essential component of Aes foci in colorectal cancer cells.
AES is a transcriptional repressor for HNF-1-alpha (show HNF1A Antibodies) in pancreatic beta-cell.
AES binds to PROP1 (show PROP1 Antibodies) and represses its expression; PROP1 (show PROP1 Antibodies) mutation is a likely cause of combined pituitary hormone (show CGA Antibodies) deficiency.
GRG5/AES interacts with TCF4 (show TCF4 Antibodies) and represses Wnt (show WNT2 Antibodies)-mediated transcription both in human cells and zebrafish embryos.
alteration of the malignant behavior of cancer cells by AES is related to RND3 (show RND3 Antibodies) regulation.
In the presence of NUP98 (show NUP98 Antibodies)-HOXA9 (show HOXA9 Antibodies), AES caused an increase in long-term proliferation of primary human CD34 (show CD34 Antibodies)+ cells with a marked increase in the numbers of primitive cells.
Elevated levels of AES mRNA (show RUNX1 Antibodies)and (show RUNX1T1 Antibodies)protein were confirmed in AML1/ETO-expressing leukemia cells, as well as in other acute myeloid leukemia specimens.
LRP6 (show LRP6 Antibodies)-ICD (show GNPTAB Antibodies) interacts with AES exclusively in the nucleus and represses AES mediated TCF (show HNF4A Antibodies)/LEF-1 (show LEF1 Antibodies) reporter transcription.
in a transplantation mouse model of liver metastases, expression of Yy2 (show YY2 Antibodies) (and therefore of Aes) is downregulated
The finding that Foxh1 (show FOXH1 Antibodies)-Grg-mediated repression is not essential for Nodal expression during mouse embryogenesis suggests that other regulators compensate for the loss of repressive regulatory input that is mediated by Grg interactions.
Self-renewal induced by AML1 (show RUNX1 Antibodies)/ETO (show RUNX1T1 Antibodies) in primary murine progenitors was inhibited when Aes was decreased or absent.
The Aes gene functions as an endogenous metastasis suppressor. Aes inhibits Notch (show NOTCH1 Antibodies) signaling by converting active Rbpj (show RBPJ Antibodies) transcription complexes into repression complexes on insoluble nuclear matrix.
Data suggest that Grg5 modulates the activities of transcription factors in vivo to affect Ihh (show IHH Antibodies) expression and the function of long bone growth plates.
Tcf4 (show TCF4 Antibodies) and Aes influence pituitary growth and development, and place Tcf4 (show TCF4 Antibodies) and Tle3 (show TLE3 Antibodies) in the genetic hierarchy with Prop1 (show PROP1 Antibodies)
Grg5 acts as a positive regulator of Runx2 (show RUNX2 Antibodies) activity and is necessary for full expression and signalling of Indian hedgehog (Ihh (show IHH Antibodies)).
Data show that GRG proteins, including GRG5, interact with two regulators of GnRH transcription, the homeodomain proteins MSX1 and OCT1, and regulate GnRH promoter activity.
direct interaction between Otx2 and Grg co-repressors regulates GnRH gene expression in hypothalamic neurons
GRG5/AES interacts with TCF4 (show TCF7L2 Antibodies) and represses Wnt (show WNT2 Antibodies)-mediated transcription both in human cells and zebrafish embryos.
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene.
gp130-associated protein GAM
, related to Drosophila groucho
, amino enhancer of split
, amino enhancer split
, amino-terminal enhancer of split
, transducin-like enhancer of split 4 homolog of Drosophila E(spl)