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Data suggest a critical role of dickkopf 4 (DKK4) in docetaxel resistance of the lung adenocarcinoma A549 (A549/DTX (show DTX1 Proteins)) cells.
in NOD/SCID (show PRKDC Proteins) mice supplemented with high glucose, HepG2 xenografted tumors grew rapidly in which elevated levels of beta-catenin (show CTNNB1 Proteins), c-Myc (show MYC Proteins) and decreased levels of DKK4 were detected. Knockdown of DKK4 by shRNA promotes proliferation of HCC (show FAM126A Proteins) cells in NG, which is suppressed by treating cells exogenously with recombinant DKK4 protein. Our in vitro and in vivo results indicate an important functional role of DKK4 in glucose fa...
Our results indicated that DKK4 might be contributed to predicting EOC progression and prognosis. DKK4 could promote the invasion of EOC through JNK (show MAPK8 Proteins) activation.
We found that TCF7L1 (show TCF3 Proteins) recruits the C-terminal binding protein (CtBP (show CTBP2 Proteins)) and histone deacetylase 1 (HDAC1 (show HDAC1 Proteins)) to the DKK4 promoter to repress DKK4 gene expression. In the absence of TCF7L1 (show TCF3 Proteins), TCF7L2 (show TCF7L2 Proteins) and beta-catenin (show CTNNB1 Proteins) occupancy at the DKK4 promoter is stimulated and DKK4 expression is increased. These findings uncover a critical role for TCF7L1 (show TCF3 Proteins) in repressing DKK4 gene expression to promote the oncogenic potential of CRCs.
DKK4 expression is significantly upregulated in human masticatory mucosa during wound healing
DKK4 may have function on the development and progression of pancreatic cancer.
The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR (show GSR Proteins) and AA rs3763511of gene DKK4.
DKK4 upregulated by T3/TR antagonizes the Wnt (show WNT2 Proteins) signal pathway to suppress tumor cell progression
rs3923086 in AXIN2 (show AXIN2 Proteins) and rs3763511 in DKK4 that did not show any association in the overall population were significantly associated with early on-set and estrogen receptor (show ESR1 Proteins) negative breast cancers, respectively.
It would appear that deregulation of the WNT (show WNT2 Proteins) pathway by overexpression of DKK4 may further impair WNT (show WNT2 Proteins) signaling and lead to Anorectal malformations.
the dynamic state of Dkk4 itself and its interaction with Lrp6 (show LRP6 Proteins) modulates Wnt (show WNT2 Proteins) function during Meibomian gland development, with a novel limitation of Dkk4 action by proteolytic cleavage.
sweat gland development shows a relay of regulatory steps initiated by Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) - itself modulated by Dkk4 - with subsequent participation of Eda (show EDA Proteins) and Shh (show SHH Proteins) pathways.
These results showed that Dkk4 functions as an inhibitor of osteoblastogenesis through Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling, providing new insights into the relationship between Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling and Dkk4 in bone formation.
Dkk4 affects an auxiliary pathway for Eda (show EDA Proteins)-independent development of secondary hair
Dkk4 acts in a negative feedback loop to attenuate canonical Wnt (show WNT2 Proteins) signaling and may facilitate a switch to the non-canonical Wnt (show WNT2 Proteins) planar cell polarity pathway that is involved in cell movements during morphogenesis.
Microarray profiling of genes differentially regulated by short exposure to recombinant Eda-A1 (show EDA Proteins) in embryonic eda (show EDA Proteins)(-/-) skin explants, was performed to identify direct targets of ectodysplasin pathway.
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2.
, dickkopf-related protein 4
, dickkopf homolog 4
, LOW QUALITY PROTEIN: dickkopf-related protein 4