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anti-Human FZD4 Antibodies:
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Human Monoclonal FZD4 Primary Antibody for IHC (fro), FACS - ABIN2689205
Ells, Guernsey, Wallace, Zheng, Vincer, Allen, Ingram, DaSilva, Siebert, Sheidow, Beis, Robitaille: Severe retinopathy of prematurity associated with FZD4 mutations. in Ophthalmic genetics 2010
Show all 8 Pubmed References
Cow (Bovine) Polyclonal FZD4 Primary Antibody for IHC, WB - ABIN2776715
Dufourcq, Leroux, Ezan, Descamps, Lamazière, Costet, Basoni, Moreau, Deutsch, Couffinhal, Duplàa: Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. in The American journal of pathology 2008
Show all 4 Pubmed References
Human Monoclonal FZD4 Primary Antibody for CyTOF, FACS - ABIN4900304
Baksh, Boland, Tuan: Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation. in Journal of cellular biochemistry 2007
Show all 2 Pubmed References
Human Monoclonal FZD4 Primary Antibody for FACS, ICC - ABIN4898976
Despeaux, Chicanne, Rouer, De Toni-Costes, Bertrand, Mansat-De Mas, Vergnolle, Eaves, Payrastre, Girault, Racaud-Sultan: Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling. in Stem cells (Dayton, Ohio) 2012
Human Polyclonal FZD4 Primary Antibody for ELISA, WB - ABIN408660
You, Nguyen, Albers, Lin, Holcombe: Wnt pathway-related gene expression in inflammatory bowel disease. in Digestive diseases and sciences 2008
Knockdown of Tc-fz1 alone interfered with the formation of the proximo-distal and the dorso-ventral axes during leg development, whereas no effect was observed with single Tc-fz2 (show FZD2 Antibodies) or Tc-fz4 RNAi knockdowns.
FzM1.8 is an allosteric agonist of FZD4. In the absence of any WNT (show WNT2 Antibodies) ligand, FzM1.8 binds to FZD4, promotes recruitment of heterotrimeric G proteins, and biases WNT (show WNT2 Antibodies) signaling toward a noncanonical route that involves PI3K (show PIK3CA Antibodies). In colon cancer cells, the FZD4/PI3K (show PIK3CA Antibodies) axis elicited by FzM1.8 preserves stemness and promotes proliferation of undifferentiated cells.
FZD4 Tyrosine 250(2.39) is crucial for DVL2 (show DVL2 Antibodies) interaction and DVL2 (show DVL2 Antibodies) translocation to the plasma membrane.
Accessory proteins in Frizzled (FZD) receptor complexes are thought to determine ligand selectivity and signaling amplitude.
FZD4 was confirmed to be a downstream target of miR (show MLXIP Antibodies)-505, and found to be up-regulated in cervical cancer patients.
The screening of candidate genes namely NDP (show NDP Antibodies), FZD4 and TSPAN12 (show TSPAN12 Antibodies) led to the identification of six major coding region variants in 36 ROP (show STXBP1 Antibodies) probands.
Seven novel mutations found in this study have broadened the spectrum of mutations in FZD4 known to cause familial exudative vitreoretinopathy (FEVR (show NDP Antibodies)), providing a deeper understanding of this disease. The results show that mutations in FZD4 are associated with the phenotypes of retinal folds or ectopic macula in FEVR (show NDP Antibodies)
Three affected individuals within a family with FEVR (show NDP Antibodies) presented with variable disease severity. All three affected family members harboured mutation c.349T>C (p.Cys117Arg) in FZD4.
The findings in this family support the concept that some mutated FZD4 alleles can be associated with recessive rather than dominant disease.
novel role of let-7b/Fzd4 axis through wnt (show WNT2 Antibodies) signaling
Study shows that WNT5A (show WNT5A Antibodies) stimulates dimerization of membrane-anchored FZD4 CRDs and oligomerization of full-length FZD4, which requires the integrity of CRD (show CRX Antibodies) palmitoleoyl-binding residues. These results suggest that FZD receptors may form signalosomes in response to Wnt (show WNT2 Antibodies) binding through the CRDs and that the Wnt (show WNT2 Antibodies) palmitoleoyl group is important in promoting these interactions.
Hnf1beta (show HNF1B Antibodies) and Fzd4/Fzd4s appear to be involved in pre-patterning events of the embryonic endoderm that allow pancreas formation in Xenopus.
A splice variant of the Frizzled-4 receptor modulates Wnt (show WNT2 Antibodies) signalling in a dose-dependent, biphasic manner.
FZD4 was upregulated during cyclic mechanical stretch (CMS (show Cd2ap Antibodies))-induced osteogenic differentiation, and the JNK (show MAPK8 Antibodies) signalling pathway was activated. FZD4 knockdown inhibited the mechanical stimuli-induced osteogenesis and JNK (show MAPK8 Antibodies) activity.
These data expose a stromal component that regulates the earliest stages of tumorigenesis in the cerebellum, and a novel role for the Norrin (show NDP Antibodies)/Fzd4 axis as an endogenous anti-tumor signal in the preneoplastic niche.
Fzd4 and Fzd6 (show FZD6 Antibodies) genes have a deep patterning effect on arterial vessel morphogenesis that may determine its functional efficiency
Study identified a novel Wnt5a (show WNT5A Antibodies)/Fzd4 signaling pathway that contributes to the regulation of dendrite morphogenesis
These results question the conclusion that a dominant-negative mechanism would explain the dominance of the mutant L501fsX533 Fz4 allele in the transmission of a form of Familial exudative vitreoretinopathy.
The data reveal both cell-autonomous and cell-nonautonomous effects, and they imply a central role for Norrin (show NDP Antibodies)/Fz4 signaling in central nervous system vascular development and in the maintenance of the blood brain barrier/blood retina barrier state.
Frizzled 4 regulates arterial network organization through noncanonical Wnt (show WNT2 Antibodies)/planar cell polarity signaling.
Frizzled4 wnt (show WNT2 Antibodies) receptors are significantly increased in pathological neovascularization in a mouse model of oxygen-induced proliferative retinopathy.
targeted inactivation of the TSK (show FBN1 Antibodies) gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b (show WNT2B Antibodies) and Fzd4 expression in the developing peripheral eye
These results demonstrate that FZD4 is required for physiological and pathologic angiogenesis in the retina and for regulation of retinal endothelial cell differentiation.
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.
, frizzled homolog 1
, frizzled homolog 4
, WNT receptor frizzled-4
, frizzled 4, seven transmembrane spanning receptor
, frizzled receptor 4
, frizzled 4 protein